HSFY2 (Homo sapiens)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00447 (HSF_DNA-bind) IPR000232 ENSG00000169953 T240224_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HSFY2
M03326_2.00		 Homo sapiens
WTCGAWNVRWTCGAW
WTCGAWYBNWTCGAW		 SELEX
Jolma et al.(2013)
HSFY2_1		 (Direct) (Direct)
HSFY2
M03327_2.00		 Homo sapiens
CRTTCGAWW
WWTCGAAYG		 SELEX
Jolma et al.(2013)
HSFY2_2		 (Direct) (Direct)
HSFY2
M03328_2.00		 Homo sapiens
DTCGAAHSNWTCGAW
WTCGAWNSDTTCGAH		 SELEX
Jolma et al.(2013)
HSFY2_3		 (Direct) (Direct)
HSFY2
M05511_2.00		 Homo sapiens
NDTVGAAYGWTTCGAAYGB
VCRTTCGAAWCRTTCBAHN		 SELEX
Yin et al.(2017)
HSFY2_eDBD_HT-SELEX_1		 (Direct) (Direct)
HSFY2
M05512_2.00		 Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY2_eDBD_HT-SELEX_2		 (Direct) (Direct)
HSFY2
M05513_2.00		 Homo sapiens
NDWRGAAYGTTTRGAAYGB
VCRTTCYAAACRTTCYWHN		 SELEX
Yin et al.(2017)
HSFY2_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
HSFY2
M05514_2.00		 Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY2_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HSFY1
M05515_2.00 		Homo sapiens
NDTVGAAYGWTTCGAAYGB
VCRTTCGAAWCRTTCBAHN		 SELEX
Yin et al.(2017)
HSFY1_eDBD_HT-SELEX_1 		0.517 0.788
HSFY1
M05516_2.00 		Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY1_eDBD_HT-SELEX_2 		0.517 0.788
HSFY1
M05517_2.00 		Homo sapiens
NDTRGAATGTTTRGAATGB
VCATTCYAAACATTCYAHN		 SELEX
Yin et al.(2017)
HSFY1_eDBD_Methyl-HT-SELEX_1 		0.517 0.788
HSFY1
M05518_2.00 		Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY1_eDBD_Methyl-HT-SELEX_2 		0.491 0.717
HSF5
M05519_2.00 		Homo sapiens
NRCRTTCTAGAACGYN
NRCGTTCTAGAAYGYN		 SELEX
Yin et al.(2017)
HSF5_eDBD_HT-SELEX_1 		0.323 0.432
HSF5
M05520_2.00 		Homo sapiens
YVGAAYRYNNNNNNNNNBHACRTTCBR
YVGAAYGTDVNNNNNNNNNRYRTTCBR		 SELEX
Yin et al.(2017)
HSF5_eDBD_HT-SELEX_2 		0.323 0.432
HSF5
M05521_2.00 		Homo sapiens
AACRTTCTAGAAYGTT
AACRTTCTAGAAYGTT		 SELEX
Yin et al.(2017)
HSF5_eDBD_Methyl-HT-SELEX_1 		0.323 0.432
HSF5
M05522_2.00 		Homo sapiens
YRGAAYDYNVNNNNNNNBAACRTTCYR
YRGAAYGTTVNNNNNNNBNRHRTTCYR		 SELEX
Yin et al.(2017)
HSF5_eDBD_Methyl-HT-SELEX_2 		0.323 0.432
For this family, TFs with SR scores > 0.318 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000306549 HSF 80 195
ENSP00000340971 HSF 80 183
ENSP00000372303 HSF 80 193

Links

Other HSF family TFs
Other Homo sapiens TFs

139 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
HSFY1 Homo sapiens ENSG00000172468 D 0.647
ENSMLUG00000024907 Myotis lucifugus ENSMLUG00000024907 I 0.579
ENSCSAG00000018308 Chlorocebus sabaeus ENSCSAG00000018308 I 0.577
ENSMLUG00000015387 Myotis lucifugus ENSMLUG00000015387 I 0.570
ENSECAG00000000093 Equus caballus ENSECAG00000000093 I 0.555
ENSBTAG00000046306 Bos taurus ENSBTAG00000046306 I 0.529
Hsfy2 Rattus norvegicus ENSRNOG00000038569 I 0.528
Hsfy2 Mus musculus ENSMUSG00000045336 I 0.528
ENSVPAG00000010189 Vicugna pacos ENSVPAG00000010189 I 0.522
Cmyd_10018130 Chelonia mydas Cmyd_10018130 I 0.522
ENSOANG00000012192 Ornithorhynchus anatinus ENSOANG00000012192 I 0.505
ENSVPAG00000003263 Vicugna pacos ENSVPAG00000003263 I 0.504
Pvit_14501 Pogona vitticeps Pvit_14501 I 0.504
ENSVPAG00000004400 Vicugna pacos ENSVPAG00000004400 I 0.502
ENSLACG00000012431 Latimeria chalumnae ENSLACG00000012431 I 0.500
ENSGGOG00000024390 Gorilla gorilla ENSGGOG00000024390 I 0.500
Ogr08578 Ophisaurus gracilis Ogr08578 I 0.494
ENSVPAG00000004671 Vicugna pacos ENSVPAG00000004671 I 0.493
ENSBTAG00000045938 Bos taurus ENSBTAG00000045938 I 0.489
ENSVPAG00000003548 Vicugna pacos ENSVPAG00000003548 I 0.488
ENSVPAG00000006426 Vicugna pacos ENSVPAG00000006426 I 0.487
ENSACAG00000008631 Anolis carolinensis ENSACAG00000008631 I 0.484
ENSLOCG00000014483 Lepisosteus oculatus ENSLOCG00000014483 I 0.481
ENSOANG00000001091 Ornithorhynchus anatinus ENSOANG00000001091 I 0.477
ENSMEUG00000003908 Macropus eugenii ENSMEUG00000003908 I 0.477
ENSOANG00000028803 Ornithorhynchus anatinus ENSOANG00000028803 I 0.475
ENSVPAG00000005620 Vicugna pacos ENSVPAG00000005620 I 0.474
ENSMODG00000027398 Monodelphis domestica ENSMODG00000027398 I 0.471
DICVIV_13476 Dictyocaulus viviparus DICVIV_13476 I 0.462
ENSMODG00000028107 Monodelphis domestica ENSMODG00000028107 I 0.462
Afo_R012751 Aptenodytes forsteri Afo_R012751 I 0.461
ENSVPAG00000007875 Vicugna pacos ENSVPAG00000007875 I 0.445
ENSPTRG00000028817 Pan troglodytes ENSPTRG00000028817 I 0.444
ENSPTRG00000022495 Pan troglodytes ENSPTRG00000022495 I 0.443
ENSSSCG00000012734 Sus scrofa ENSSSCG00000012734 I 0.439
ENSBTAG00000047168 Bos taurus ENSBTAG00000047168 I 0.432
Aan_R010039 Calypte anna Aan_R010039 I 0.429
Gfo_R015012 Geospiza fortis Gfo_R015012 I 0.418
ENSBTAG00000035623 Bos taurus ENSBTAG00000035623 I 0.417
Tal_R003042 Tyto alba Tal_R003042 I 0.415
ENSGALG00000019262 Gallus gallus ENSGALG00000019262 I 0.413
ENSVPAG00000004668 Vicugna pacos ENSVPAG00000004668 I 0.412
ENSDNOG00000043873 Dasypus novemcinctus ENSDNOG00000043873 I 0.412
ENSP00000359444 Macaca fascicularis ENSP00000359444 I 0.407
ENSPANG00000004032 Papio anubis ENSPANG00000004032 I 0.407
ENSMMUG00000002887 Macaca mulatta ENSMMUG00000002887 I 0.407
ENSCSAG00000007182 Chlorocebus sabaeus ENSCSAG00000007182 I 0.405
ENSTGUG00000006066 Taeniopygia guttata ENSTGUG00000006066 I 0.403
ENSTGUG00000006065 Taeniopygia guttata ENSTGUG00000006065 I 0.403
ENSAMEG00000014907 Ailuropoda melanoleuca ENSAMEG00000014907 I 0.401
ENSVPAG00000007931 Vicugna pacos ENSVPAG00000007931 I 0.401
HSFX2 Homo sapiens ENSG00000268738 I 0.399
ENSECAG00000009495 Equus caballus ENSECAG00000009495 I 0.399
HSFX1 Homo sapiens ENSG00000171116 I 0.399
ENSCAFG00000023067 Canis familiaris ENSCAFG00000023067 I 0.397
ENSCAFG00000029639 Canis familiaris ENSCAFG00000029639 I 0.397
ENSECAG00000008677 Equus caballus ENSECAG00000008677 I 0.396
ENSFALG00000008921 Ficedula albicollis ENSFALG00000008921 I 0.396
ENSPPYG00000020808 Pongo abelii ENSPPYG00000020808 I 0.395
ENSCAFG00000023024 Canis familiaris ENSCAFG00000023024 I 0.394
ENSECAG00000008708 Equus caballus ENSECAG00000008708 I 0.389
ENSLAFG00000016976 Loxodonta africana ENSLAFG00000016976 I 0.388
ENSMGAG00000013753 Meleagris gallopavo ENSMGAG00000013753 I 0.383
ENSFCAG00000025614 Felis catus ENSFCAG00000025614 I 0.382
Gfo_R015011 Geospiza fortis Gfo_R015011 I 0.381
Tal_R002418 Tyto alba Tal_R002418 I 0.379
ENSCJAG00000004097 Callithrix jacchus ENSCJAG00000004097 I 0.378
ENSGGOG00000022734 Gorilla gorilla ENSGGOG00000022734 I 0.378
ENSNLEG00000013483 Nomascus leucogenys ENSNLEG00000013483 I 0.377
ENSMLUG00000022730 Myotis lucifugus ENSMLUG00000022730 I 0.375
Myotis_brandtii_HSFY1_10020625 Myotis brandtii Myotis_brandtii_HSFY1_10020625 I 0.375
ENSCAFG00000031919 Canis familiaris ENSCAFG00000031919 I 0.373
ENSDNOG00000015218 Dasypus novemcinctus ENSDNOG00000015218 I 0.373
ENSOGAG00000026441 Otolemur garnettii ENSOGAG00000026441 I 0.373
ENSCAFG00000025411 Canis familiaris ENSCAFG00000025411 I 0.373
ENSAMEG00000009347 Ailuropoda melanoleuca ENSAMEG00000009347 I 0.371
ENSDNOG00000045058 Dasypus novemcinctus ENSDNOG00000045058 I 0.366
ENSAPLG00000009652 Anas platyrhynchos ENSAPLG00000009652 I 0.365
ENSBTAG00000036115 Bos taurus ENSBTAG00000036115 I 0.361
ENSBTAP00000047496-D1 Bos grunniens ENSBTAP00000047496-D1 I 0.358
ENSBTAG00000036343 Bos taurus ENSBTAG00000036343 I 0.357
ENSCPOG00000021607 Cavia porcellus ENSCPOG00000021607 I 0.357
ENSPFOG00000024243 Poecilia formosa ENSPFOG00000024243 I 0.355
ENSLAFG00000031072 Loxodonta africana ENSLAFG00000031072 I 0.354
HSF5 Cavia porcellus ENSCPOG00000003431 I 0.354
ENSP00000410851-D3 Bos grunniens ENSP00000410851-D3 I 0.354
ENSSTOG00000025684 Ictidomys tridecemlineatus ENSSTOG00000025684 I 0.353
ENSCPOG00000027550 Cavia porcellus ENSCPOG00000027550 I 0.353
ENSCJAG00000032803 Callithrix jacchus ENSCJAG00000032803 I 0.352
ENSPPYG00000019906 Pongo abelii ENSPPYG00000019906 I 0.351
ENSAPLG00000001200 Anas platyrhynchos ENSAPLG00000001200 I 0.350
Alligator_sinensis_CCG007789.1 Alligator sinensis Alligator_sinensis_CCG007789.1 I 0.349
ENSGALG00000027212 Gallus gallus ENSGALG00000027212 I 0.348
ENSLAFG00000010861 Loxodonta africana ENSLAFG00000010861 I 0.347
Thhalv10012073m.g Eutrema salsugineum Thhalv10012073m.g I 0.345
ENSMLUG00000030480 Myotis lucifugus ENSMLUG00000030480 I 0.344
ENSMGAG00000014469 Meleagris gallopavo ENSMGAG00000014469 I 0.343
ENSMGAG00000003672 Meleagris gallopavo ENSMGAG00000003672 I 0.338
ENSSSCG00000012732 Sus scrofa ENSSSCG00000012732 I 0.337
ENSBTAG00000033445 Bos taurus ENSBTAG00000033445 I 0.336
ENSBTAP00000044770-D1 Bos grunniens ENSBTAP00000044770-D1 I 0.336
ENSOARG00000002879 Ovis aries ENSOARG00000002879 I 0.336
ENSMLUG00000028032 Myotis lucifugus ENSMLUG00000028032 I 0.335
ENSTRUG00000015486 Takifugu rubripes ENSTRUG00000015486 I 0.334
ENSOCUG00000025707 Oryctolagus cuniculus ENSOCUG00000025707 I 0.333
ENSTBEG00000002283 Tupaia belangeri ENSTBEG00000002283 I 0.333
ENSDNOG00000031164 Dasypus novemcinctus ENSDNOG00000031164 I 0.332
ENSOARG00000003920 Ovis aries ENSOARG00000003920 I 0.332
Al_scaffold_0003_3814 Arabidopsis lyrata Al_scaffold_0003_3814 I 0.331
hsf1 Schizosaccharomyces pombe SPAC2E12.02 I 0.331
ENSGALG00000028720 Gallus gallus ENSGALG00000028720 I 0.330
ENSMGAG00000014467 Meleagris gallopavo ENSMGAG00000014467 I 0.328
SPOG_01941 Schizosaccharomyces cryophilus SPOG_01941 I 0.328
SOCG_00564 Schizosaccharomyces octosporus SOCG_00564 I 0.328
HSF5 Gorilla gorilla ENSGGOG00000013788 I 0.327
ENSTRUG00000004613 Takifugu rubripes ENSTRUG00000004613 I 0.325
ENSTRUG00000008763 Takifugu rubripes ENSTRUG00000008763 I 0.324
HSF5 Pan troglodytes ENSPTRG00000009453 I 0.323
HSF5 Homo sapiens ENSG00000176160 D 0.323
ENSBTAG00000047120 Bos taurus ENSBTAG00000047120 I 0.323
J056_002394 Wallemia ichthyophaga J056_002394 I 0.323
FIBRA_02011 Fibroporia radiculosa FIBRA_02011 I 0.323
ENSTTRG00000003386 Tursiops truncatus ENSTTRG00000003386 N 0.321
ENSTTRG00000000641 Tursiops truncatus ENSTTRG00000000641 N 0.321
ENSMGAG00000013806 Meleagris gallopavo ENSMGAG00000013806 I 0.320
SCLCIDRAFT_1218516 Scleroderma citrinum SCLCIDRAFT_1218516 I 0.320
ENSTRUG00000012122 Takifugu rubripes ENSTRUG00000012122 I 0.320
ENSMGAG00000005814 Meleagris gallopavo ENSMGAG00000005814 I 0.319
ENSMEUG00000007286 Macropus eugenii ENSMEUG00000007286 I 0.319
HSF5 Bos taurus ENSBTAG00000001166 I 0.319
HSF5 Sus scrofa ENSSSCG00000017641 I 0.319
ENSPPYG00000008231 Pongo abelii ENSPPYG00000008231 I 0.319
HSF5 Procavia capensis ENSPCAG00000011323 I 0.319
ENSSTOG00000020272 Ictidomys tridecemlineatus ENSSTOG00000020272 I 0.319
HSF5 Dasypus novemcinctus ENSDNOG00000014871 I 0.319
HSF5 Canis familiaris ENSCAFG00000017528 I 0.319
Hsf5 Mus musculus ENSMUSG00000070345 I 0.319
ENSLOCG00000002988 Lepisosteus oculatus ENSLOCG00000002988 I 0.318