CIS-BP Database: Catalog of Inferred Sequence Binding Preferences

TF Information

nhr-177 *(Caenorhabditis elegans)* Nuclear receptor
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00105 (zf-C4)	IPR001628	WBGene00017503	T306337_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
nhr-177 M02419_2.00	Caenorhabditis elegans	TCGRGANY	RNTCYCGA	PBM Weirauch et al.(2014) pTH9044	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
For this family, TFs with SR scores > 0.745* will likely have a similar motif*

Experimental Constructs

Motif ID	Domain	From	To	Sequence
M02419_2.00	Nuclear receptor	32	103	KDCRICFEKGHGYHFGVFSCRACAAFFRRCHFLKENRRRCRLSKGKCGPNKNGKWFCKTCRLERCFRLGMTP

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
F16B4.1	Nuclear receptor	32	103	KDCRICFEKGHGYHFGVFSCRACAAFFRRCHFLKENRRRCRLSKGKCGPNKNGKWFCKTCRLERCFRLGMTP

Links
Other Nuclear receptor family TFs
Other *Caenorhabditis elegans* TFs