TBX6 (Homo sapiens)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSG00000149922 T339895_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
TBX6
M05805_2.00
Homo sapiens
NRSGTGTBAN

NTVACACSYN
SELEX
Yin et al.(2017)
TBX6_eDBD_HT-SELEX
(Direct) (Direct)
TBX6
M05806_2.00
Homo sapiens
NTVRCACBHN

NDVGTGYBAN
SELEX
Yin et al.(2017)
TBX6_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000279386 T-box 93 273
ENSP00000378650 T-box 93 273
ENSP00000460425 T-box 93 273
ENSP00000461223 T-box 93 273
ENSP00000485762 T-box 93 260

Links

Other T-box family TFs
Other Homo sapiens TFs

38 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
TBX6 Pteropus vampyrus ENSPVAG00000010556 I 0.904
ENSPANG00000000556 Papio anubis ENSPANG00000000556 I 0.892
TBX6 Gorilla gorilla ENSGGOG00000012924 I 0.892
TBX6 Otolemur garnettii ENSOGAG00000011659 I 0.892
TBX6 Macaca mulatta ENSMMUG00000000981 I 0.892
TBX6 Microcebus murinus ENSMICG00000009134 I 0.892
ENSPPYG00000007242 Pongo abelii ENSPPYG00000007242 I 0.892
TBX6 Pan troglodytes ENSPTRG00000007985 I 0.892
ENSNLEG00000002044 Nomascus leucogenys ENSNLEG00000002044 I 0.892
TBX6 Callithrix jacchus ENSCJAG00000035904 I 0.892
ENSCSAG00000006175 Chlorocebus sabaeus ENSCSAG00000006175 I 0.892
TBX6 Oryctolagus cuniculus ENSOCUG00000026026 I 0.889
TBX6 Cavia porcellus ENSCPOG00000021165 I 0.889
ENSSTOG00000000869 Ictidomys tridecemlineatus ENSSTOG00000000869 I 0.889
Tbx6 Rattus norvegicus ENSRNOG00000019771 I 0.884
Tbx6 Mus musculus ENSMUSG00000030699 I 0.884
ENSMPUG00000012586 Mustela putorius furo ENSMPUG00000012586 I 0.879
TBX6 Equus caballus ENSECAG00000022374 I 0.879
TBX6 Bos taurus ENSBTAG00000009046 I 0.879
ENSBTAP00000011919-D1 Bos grunniens ENSBTAP00000011919-D1 I 0.879
TBX6 Loxodonta africana ENSLAFG00000017884 I 0.879
ENSEEUG00000012843 Erinaceus europaeus ENSEEUG00000012843 I 0.879
TBX6 Procavia capensis ENSPCAG00000000071 I 0.877
ENSOARG00000004040 Ovis aries ENSOARG00000004040 I 0.876
Myotis_brandtii_TBX6_10014444 Myotis brandtii Myotis_brandtii_TBX6_10014444 I 0.876
TBX6 Myotis lucifugus ENSMLUG00000011244 I 0.876
TBX6 Felis catus ENSFCAG00000014172 I 0.869
TBX6 Monodelphis domestica ENSMODG00000015682 I 0.867
TBX6 Echinops telfairi ENSETEG00000019233 I 0.865
TBX6 Ochotona princeps ENSOPRG00000009784 I 0.862
TBX6 Tursiops truncatus ENSTTRG00000005534 I 0.823
Ogr16054 Ophisaurus gracilis Ogr16054 I 0.743
TBX6 Anolis carolinensis ENSACAG00000015031 I 0.743
T265_12717 Opisthorchis viverrini T265_12717 I 0.740
csin100383 Clonorchis sinensis csin100383 I 0.740
Pvit_12103 Pogona vitticeps Pvit_12103 I 0.738
CapteG163410 Capitella teleta CapteG163410 I 0.736