sma-4 (Caenorhabditis elegans)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 WBGene00004858 T325233_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of cell size. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head neurons; intestine; and pseudocoelom. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
sma-4
M02484_2.00		 Caenorhabditis elegans
NNCCAGACANN
NNTGTCTGGNN		 PBM
Weirauch et al.(2014)
pTH8996		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02484_2.00 SMAD 55 155

DNA Binding Domains

Protein ID Domain From To Sequence
R12B2.1a.1 SMAD 163 263
R12B2.1a.2 SMAD 163 263
R12B2.1a.3 SMAD 163 263

Links

Other SMAD family TFs
Other Caenorhabditis elegans TFs

72 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE04707 Caenorhabditis remanei CRE04707 I 0.980
CBG09090 Caenorhabditis briggsae CBG09090 I 0.980
CJA09693 Caenorhabditis japonica CJA09693 I 0.970
CBN31444 Caenorhabditis brenneri CBN31444 I 0.970
HCOI02014300 Haemonchus contortus HCOI02014300 I 0.851
HCOI01928500 Haemonchus contortus HCOI01928500 I 0.851
TELCIR_06960 Teladorsagia circumcincta TELCIR_06960 I 0.851
ANCDUO_13021 Ancylostoma duodenale ANCDUO_13021 I 0.851
ASU_10605 Ascaris suum ASU_10605 I 0.842
ASIM_0001219601 Anisakis simplex ASIM_0001219601 I 0.842
CGOC_0000897101 Cylicostephanus goldi CGOC_0000897101 I 0.842
HPBE_0002536701 Heligmosomoides bakeri HPBE_0002536701 I 0.842
nLs.2.1.2.g01829 Litomosoides sigmodontis nLs.2.1.2.g01829 I 0.842
NBR_0001377901 Nippostrongylus brasiliensis NBR_0001377901 I 0.842
ALUE_0001111401 Ascaris lumbricoides ALUE_0001111401 I 0.842
EVEC_0000562301 Enterobius vermicularis EVEC_0000562301 I 0.842
DICVIV_05422 Dictyocaulus viviparus DICVIV_05422 I 0.842
ACAC_0000977101 Angiostrongylus cantonensis ACAC_0000977101 I 0.833
L893_g15056 Steinernema glaseri L893_g15056 I 0.832
BTMF_0000952301 Brugia timori BTMF_0000952301 I 0.832
L892_g4495 Steinernema scapterisci L892_g4495 I 0.832
Bm5359 Brugia malayi Bm5359 I 0.832
WUBG_08631 Wuchereria bancrofti WUBG_08631 I 0.832
L596_g26024 Steinernema carpocapsae L596_g26024 I 0.832
OFLC_0000505301 Onchocerca flexuosa OFLC_0000505301 I 0.822
LOAG_05337 Loa loa LOAG_05337 I 0.822
nOo.2.0.1.g06266 Onchocerca ochengi nOo.2.0.1.g06266 I 0.822
Ppa-sma-4 Pristionchus pacificus PPA17857 I 0.822
nDi.2.2.2.g06233 Dirofilaria immitis nDi.2.2.2.g06233 I 0.822
nAv.1.0.1.g08553 Acanthocheilonema viteae nAv.1.0.1.g08553 I 0.822
scaffold21-EXSNAP2012.60 Pristionchus exspectatus scaffold21-EXSNAP2012.60 I 0.822
L889_g22387 Steinernema feltiae L889_g22387 I 0.822
WBGene00245700 Onchocerca volvulus WBGene00245700 I 0.822
TCLT_0000412001 Thelazia callipaeda TCLT_0000412001 I 0.812
RSKR_0000114900 Rhabditophanes kr3021 RSKR_0000114900 I 0.802
BXY_1538500 Bursaphelenchus xylophilus BXY_1538500 I 0.802
Bm11291 Brugia malayi Bm11291 I 0.795
TELCIR_11814 Teladorsagia circumcincta TELCIR_11814 I 0.793
Minc06316 Meloidogyne incognita Minc06316 I 0.792
Minc10272 Meloidogyne incognita Minc10272 I 0.792
SSTP_0000769000 Strongyloides stercoralis SSTP_0000769000 I 0.782
GPLIN_000764400 Globodera pallida GPLIN_000764400 I 0.782
GPUH_0001294301 Gongylonema pulchrum GPUH_0001294301 I 0.782
maker-nMf.1.1.scaf05118-snap-gene-0.7 Meloidogyne floridensis maker-nMf.1.1.scaf05118-snap-gene-0.7 I 0.782
SVE_0858500 Strongyloides venezuelensis SVE_0858500 I 0.772
SPAL_0001099400 Strongyloides papillosus SPAL_0001099400 I 0.772
PTRK_0001020700 Parastrongyloides trichosuri PTRK_0001020700 I 0.762
D918_00298 Trichuris suis D918_00298 I 0.740
Hba_14016 Heterorhabditis bacteriophora Hba_14016 I 0.740
ASIM_0001604001 Anisakis simplex ASIM_0001604001 I 0.733
nDi.2.2.2.g01429 Dirofilaria immitis nDi.2.2.2.g01429 I 0.733
SMAD4 Homo sapiens ENSG00000141646 D 0.727
nAv.1.0.1.g00430 Acanthocheilonema viteae nAv.1.0.1.g00430 I 0.725
nLs.2.1.2.g01457 Litomosoides sigmodontis nLs.2.1.2.g01457 I 0.725
EEL_0000707501 Elaeophora elaphi EEL_0000707501 I 0.725
ASU_13433 Ascaris suum ASU_13433 I 0.723
TCLT_0000917301 Thelazia callipaeda TCLT_0000917301 I 0.716
WBGene00241622 Onchocerca volvulus WBGene00241622 I 0.716
GPUH_0001329001 Gongylonema pulchrum GPUH_0001329001 I 0.716
nOo.2.0.1.g00181 Onchocerca ochengi nOo.2.0.1.g00181 I 0.716
SMAD4 Microcebus murinus ENSMICG00000017525 I 0.708
SMAD4 Pteropus vampyrus ENSPVAG00000004261 I 0.708
ANCCAN_26651 Ancylostoma caninum ANCCAN_26651 I 0.707
TMUE_s0006012700 Trichuris muris TMUE_s0006012700 I 0.706
TTRE_0000855901 Trichuris trichiura TTRE_0000855901 I 0.706
BTMF_0000404601 Brugia timori BTMF_0000404601 I 0.706
LOAG_08923 Loa loa LOAG_08923 I 0.706
Bm3575 Brugia malayi Bm3575 I 0.706
HelroG76435 Helobdella robusta HelroG76435 I 0.706
BGLB014287 Biomphalaria glabrata BGLB014287 I 0.703
Ocbimv22032358m.g Octopus bimaculoides Ocbimv22032358m.g I 0.703