CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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CLOCK
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000134852
T034288_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
CLOCK
M02789_2.00
Homo sapiens
DACACGTGYH
DRCACGTGTH
SELEX
Jolma et al.(2013)
CLOCK_1
(Direct)
(Direct)
CLOCK
M04129_2.00
Homo sapiens
NMCACGTGYN
NRCACGTGKN
SELEX
Yin et al.(2017)
CLOCK_eDBD_HT-SELEX
(Direct)
(Direct)
CLOCK
M04130_2.00
Homo sapiens
NRCRCRTGBH
DVCAYGYGYN
SELEX
Yin et al.(2017)
CLOCK_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
CLOCK
M08728_2.00
Homo sapiens
DBBBCAYKTGNNHB
VDNNCAMRTGVVVH
Misc
Kulakovskiy et al.(2013)
CLOCK_HUMAN.H11MO.0.C
(Direct)
(Direct)
CLOCK
M09849_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CLOCK_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Clock
M01735_2.00
Mus musculus
NNCAYRTGNN
NNCAYRTGNN
PBM
Weirauch et al.(2014)
pTH5056
0.914
1.000
Clock
M08760_2.00
Mus musculus
DBBBCAYKTGNNHB
VDNNCAMRTGVVVH
Misc
Kulakovskiy et al.(2013)
CLOCK_MOUSE.H11MO.0.C
0.914
1.000
Clock
M09473_2.00
Mus musculus
CACGTGNN
NNCACGTG
Misc
Heinz et al.(2010)
Liver-Clock_GSE39860
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000308741
bHLH
35
85
KRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHK
ENSP00000370723
bHLH
35
85
KRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHK
ENSP00000396649
bHLH
35
85
KRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHK
ENSP00000426983
bHLH
35
85
KRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHK
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
78 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Clock
Rattus norvegicus
ENSRNOG00000002175
I
0.914
CLOCK
Pteropus vampyrus
ENSPVAG00000008960
I
0.914
CLOCK
Pan troglodytes
ENSPTRG00000016072
I
0.914
CLOCK
Sorex araneus
ENSSARG00000002584
I
0.914
ENSSHAG00000005555
Sarcophilus harrisii
ENSSHAG00000005555
I
0.914
CLOCK
Tupaia belangeri
ENSTBEG00000002540
I
0.914
ENSSTOG00000016179
Ictidomys tridecemlineatus
ENSSTOG00000016179
I
0.914
CLOCK
Sus scrofa
ENSSSCG00000008909
I
0.914
ENSPSIG00000011404
Pelodiscus sinensis
ENSPSIG00000011404
I
0.914
ENSPPYG00000014762
Pongo abelii
ENSPPYG00000014762
I
0.914
clocka
Oryzias latipes
ENSORLG00000004495
I
0.914
CLOCK
Ochotona princeps
ENSOPRG00000005292
I
0.914
CLOCK
Anolis carolinensis
ENSACAG00000009335
I
0.914
ENSPANG00000006882
Papio anubis
ENSPANG00000006882
I
0.914
CLOCK
Procavia capensis
ENSPCAG00000001407
I
0.914
ENSPFOG00000017215
Poecilia formosa
ENSPFOG00000017215
I
0.914
ENSPFOG00000015083
Poecilia formosa
ENSPFOG00000015083
I
0.914
ENSTGUG00000007495
Taeniopygia guttata
ENSTGUG00000007495
I
0.914
clocka
Tetraodon nigroviridis
ENSTNIG00000004102
I
0.914
ENSP00000370723-D1
Bos grunniens
ENSP00000370723-D1
I
0.914
ENSMMUP00000002568
Macaca fascicularis
ENSMMUP00000002568
I
0.914
Brh_R001802
Buceros rhinoceros
Brh_R001802
I
0.914
Gfo_R010434
Geospiza fortis
Gfo_R010434
I
0.914
Myotis_brandtii_Clock_10026771
Myotis brandtii
Myotis_brandtii_Clock_10026771
I
0.914
Tal_R002573
Tyto alba
Tal_R002573
I
0.914
Pvit_07605
Pogona vitticeps
Pvit_07605
I
0.914
Ogr11799
Ophisaurus gracilis
Ogr11799
I
0.914
Afo_R013414
Aptenodytes forsteri
Afo_R013414
I
0.914
Aan_R004160
Calypte anna
Aan_R004160
I
0.914
ENSTSYG00000003546
Tarsius syrichta
ENSTSYG00000003546
I
0.914
clocka
Takifugu rubripes
ENSTRUG00000001837
I
0.914
clockb
Tetraodon nigroviridis
ENSTNIG00000017652
I
0.914
CLOCK
Tursiops truncatus
ENSTTRG00000000960
I
0.914
CLOCK
Vicugna pacos
ENSVPAG00000006438
I
0.914
ENSXMAG00000017672
Xiphophorus maculatus
ENSXMAG00000017672
I
0.914
ENSXMAG00000016928
Xiphophorus maculatus
ENSXMAG00000016928
I
0.914
ENSONIG00000002943
Oreochromis niloticus
ENSONIG00000002943
I
0.914
ENSONIG00000008797
Oreochromis niloticus
ENSONIG00000008797
I
0.914
CLOCK
Equus caballus
ENSECAG00000006331
I
0.914
CLOCK
Dasypus novemcinctus
ENSDNOG00000018101
I
0.914
clocka
Danio rerio
ENSDARG00000011703
I
0.914
CLOCK
Echinops telfairi
ENSETEG00000015604
I
0.914
ENSFALG00000003646
Ficedula albicollis
ENSFALG00000003646
I
0.914
CLOCK
Otolemur garnettii
ENSOGAG00000012464
I
0.914
CLOCK
Felis catus
ENSFCAG00000001064
I
0.914
ENSCSAG00000005019
Chlorocebus sabaeus
ENSCSAG00000005019
I
0.914
CLOCK
Cavia porcellus
ENSCPOG00000011807
I
0.914
ENSAMXG00000021792
Astyanax mexicanus
ENSAMXG00000021792
I
0.914
ENSAMXG00000005565
Astyanax mexicanus
ENSAMXG00000005565
I
0.914
ENSAMEG00000018420
Ailuropoda melanoleuca
ENSAMEG00000018420
I
0.914
ENSAPLG00000007176
Anas platyrhynchos
ENSAPLG00000007176
I
0.914
CLOCK
Bos taurus
ENSBTAG00000044044
I
0.914
CLOCK
Callithrix jacchus
ENSCJAG00000018261
I
0.914
CLOCK
Canis familiaris
ENSCAFG00000002140
I
0.914
clocka
Gasterosteus aculeatus
ENSGACG00000015939
I
0.914
ENSMPUG00000005091
Mustela putorius furo
ENSMPUG00000005091
I
0.914
CLOCK
Monodelphis domestica
ENSMODG00000020678
I
0.914
CLOCK
Macaca mulatta
ENSMMUG00000001919
I
0.914
Clock
Mus musculus
ENSMUSG00000029238
D
0.914
ENSNLEG00000008499
Nomascus leucogenys
ENSNLEG00000008499
I
0.914
CLOCK
Oryctolagus cuniculus
ENSOCUG00000022350
I
0.914
ENSOARG00000001602
Ovis aries
ENSOARG00000001602
I
0.914
CLOCK
Gallus gallus
ENSGALG00000013793
I
0.914
CLOCK
Myotis lucifugus
ENSMLUG00000010007
I
0.914
ENSLACG00000013436
Latimeria chalumnae
ENSLACG00000013436
I
0.914
CLOCK
Gorilla gorilla
ENSGGOG00000005753
I
0.914
CLOCK
Loxodonta africana
ENSLAFG00000009558
I
0.914
ENSLOCG00000014043
Lepisosteus oculatus
ENSLOCG00000014043
I
0.914
CLOCK
Meleagris gallopavo
ENSMGAG00000011742
I
0.914
ENSMEUG00000005481
Macropus eugenii
ENSMEUG00000005481
I
0.914
ENSGMOG00000004825
Gadus morhua
ENSGMOG00000004825
I
0.914
clockb
Takifugu rubripes
ENSTRUG00000015488
I
0.893
CLOCK
Ornithorhynchus anatinus
ENSOANG00000003801
I
0.890
clockb
Danio rerio
ENSDARG00000003631
I
0.882
clock
Xenopus tropicalis
XB-GENE-495448
I
0.881
clock.L
Xenopus laevis
XB-GENE-6254406
I
0.881
SNAPOd2T00001991001
Oikopleura dioica
SNAPOd2T00001991001
I
0.838