clockb (Danio rerio)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSDARG00000003631 T033619_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within circadian rhythm and photoperiodism. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CLOCK-BMAL transcription complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CLOCK (clock circadian regulator). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Clock
M01735_2.00 		Mus musculus
NNCAYRTGNN
NNCAYRTGNN		 PBM
Weirauch et al.(2014)
pTH5056 		0.882 0.902
CLOCK
M02789_2.00 		Homo sapiens
DACACGTGYH
DRCACGTGTH		 SELEX
Jolma et al.(2013)
CLOCK_1 		0.882 0.902
CLOCK
M04129_2.00 		Homo sapiens
NMCACGTGYN
NRCACGTGKN		 SELEX
Yin et al.(2017)
CLOCK_eDBD_HT-SELEX 		0.882 0.902
CLOCK
M08728_2.00 		Homo sapiens
DBBBCAYKTGNNHB
VDNNCAMRTGVVVH		 Misc
Kulakovskiy et al.(2013)
CLOCK_HUMAN.H11MO.0.C 		0.882 0.902
Clock
M08760_2.00 		Mus musculus
DBBBCAYKTGNNHB
VDNNCAMRTGVVVH		 Misc
Kulakovskiy et al.(2013)
CLOCK_MOUSE.H11MO.0.C 		0.882 0.902
Clock
M09473_2.00 		Mus musculus
CACGTGNN
NNCACGTG		 Misc
Heinz et al.(2010)
Liver-Clock_GSE39860 		0.882 0.902
CLOCK
M09849_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CLOCK_Q6 		0.882 0.902
CLOCK
M04130_2.00 		Homo sapiens
NRCRCRTGBH
DVCAYGYGYN		 SELEX
Yin et al.(2017)
CLOCK_eDBD_Methyl-HT-SELEX 		0.882 0.902
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000014344 bHLH 25 75
ENSDARP00000120780 bHLH 25 75

Links

Other bHLH family TFs
Other Danio rerio TFs

78 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CLOCK Sorex araneus ENSSARG00000002584 I 0.882
Clock Rattus norvegicus ENSRNOG00000002175 I 0.882
CLOCK Pteropus vampyrus ENSPVAG00000008960 I 0.882
ENSSHAG00000005555 Sarcophilus harrisii ENSSHAG00000005555 I 0.882
CLOCK Sus scrofa ENSSSCG00000008909 I 0.882
ENSTGUG00000007495 Taeniopygia guttata ENSTGUG00000007495 I 0.882
CLOCK Tupaia belangeri ENSTBEG00000002540 I 0.882
ENSSTOG00000016179 Ictidomys tridecemlineatus ENSSTOG00000016179 I 0.882
CLOCK Pan troglodytes ENSPTRG00000016072 I 0.882
ENSPANG00000006882 Papio anubis ENSPANG00000006882 I 0.882
clocka Oryzias latipes ENSORLG00000004495 I 0.882
CLOCK Ochotona princeps ENSOPRG00000005292 I 0.882
CLOCK Procavia capensis ENSPCAG00000001407 I 0.882
ENSPFOG00000015083 Poecilia formosa ENSPFOG00000015083 I 0.882
ENSPSIG00000011404 Pelodiscus sinensis ENSPSIG00000011404 I 0.882
ENSPPYG00000014762 Pongo abelii ENSPPYG00000014762 I 0.882
ENSPFOG00000017215 Poecilia formosa ENSPFOG00000017215 I 0.882
clocka Tetraodon nigroviridis ENSTNIG00000004102 I 0.882
clockb Tetraodon nigroviridis ENSTNIG00000017652 I 0.882
Gfo_R010434 Geospiza fortis Gfo_R010434 I 0.882
ENSP00000370723-D1 Bos grunniens ENSP00000370723-D1 I 0.882
ENSMMUP00000002568 Macaca fascicularis ENSMMUP00000002568 I 0.882
Myotis_brandtii_Clock_10026771 Myotis brandtii Myotis_brandtii_Clock_10026771 I 0.882
Ogr11799 Ophisaurus gracilis Ogr11799 I 0.882
Tal_R002573 Tyto alba Tal_R002573 I 0.882
Pvit_07605 Pogona vitticeps Pvit_07605 I 0.882
Brh_R001802 Buceros rhinoceros Brh_R001802 I 0.882
Afo_R013414 Aptenodytes forsteri Afo_R013414 I 0.882
CLOCK Tursiops truncatus ENSTTRG00000000960 I 0.882
ENSTSYG00000003546 Tarsius syrichta ENSTSYG00000003546 I 0.882
clocka Takifugu rubripes ENSTRUG00000001837 I 0.882
CLOCK Vicugna pacos ENSVPAG00000006438 I 0.882
ENSXMAG00000016928 Xiphophorus maculatus ENSXMAG00000016928 I 0.882
Aan_R004160 Calypte anna Aan_R004160 I 0.882
ENSXMAG00000017672 Xiphophorus maculatus ENSXMAG00000017672 I 0.882
CLOCK Anolis carolinensis ENSACAG00000009335 I 0.882
ENSONIG00000008797 Oreochromis niloticus ENSONIG00000008797 I 0.882
CLOCK Equus caballus ENSECAG00000006331 I 0.882
CLOCK Dasypus novemcinctus ENSDNOG00000018101 I 0.882
clocka Danio rerio ENSDARG00000011703 I 0.882
CLOCK Echinops telfairi ENSETEG00000015604 I 0.882
ENSFALG00000003646 Ficedula albicollis ENSFALG00000003646 I 0.882
ENSONIG00000002943 Oreochromis niloticus ENSONIG00000002943 I 0.882
CLOCK Homo sapiens ENSG00000134852 D 0.882
CLOCK Felis catus ENSFCAG00000001064 I 0.882
ENSCSAG00000005019 Chlorocebus sabaeus ENSCSAG00000005019 I 0.882
CLOCK Cavia porcellus ENSCPOG00000011807 I 0.882
ENSAMXG00000021792 Astyanax mexicanus ENSAMXG00000021792 I 0.882
ENSAMXG00000005565 Astyanax mexicanus ENSAMXG00000005565 I 0.882
ENSAMEG00000018420 Ailuropoda melanoleuca ENSAMEG00000018420 I 0.882
ENSAPLG00000007176 Anas platyrhynchos ENSAPLG00000007176 I 0.882
CLOCK Bos taurus ENSBTAG00000044044 I 0.882
CLOCK Callithrix jacchus ENSCJAG00000018261 I 0.882
CLOCK Canis familiaris ENSCAFG00000002140 I 0.882
CLOCK Gallus gallus ENSGALG00000013793 I 0.882
clocka Gasterosteus aculeatus ENSGACG00000015939 I 0.882
Clock Mus musculus ENSMUSG00000029238 D 0.882
ENSMPUG00000005091 Mustela putorius furo ENSMPUG00000005091 I 0.882
CLOCK Gorilla gorilla ENSGGOG00000005753 I 0.882
ENSNLEG00000008499 Nomascus leucogenys ENSNLEG00000008499 I 0.882
ENSOARG00000001602 Ovis aries ENSOARG00000001602 I 0.882
CLOCK Otolemur garnettii ENSOGAG00000012464 I 0.882
CLOCK Oryctolagus cuniculus ENSOCUG00000022350 I 0.882
CLOCK Macaca mulatta ENSMMUG00000001919 I 0.882
CLOCK Monodelphis domestica ENSMODG00000020678 I 0.882
ENSLACG00000013436 Latimeria chalumnae ENSLACG00000013436 I 0.882
ENSGMOG00000004825 Gadus morhua ENSGMOG00000004825 I 0.882
CLOCK Myotis lucifugus ENSMLUG00000010007 I 0.882
CLOCK Loxodonta africana ENSLAFG00000009558 I 0.882
CLOCK Meleagris gallopavo ENSMGAG00000011742 I 0.882
ENSMEUG00000005481 Macropus eugenii ENSMEUG00000005481 I 0.882
ENSLOCG00000014043 Lepisosteus oculatus ENSLOCG00000014043 I 0.882
SNAPOd2T00001991001 Oikopleura dioica SNAPOd2T00001991001 I 0.870
clockb Takifugu rubripes ENSTRUG00000015488 I 0.861
CLOCK Ornithorhynchus anatinus ENSOANG00000003801 I 0.858
clock.L Xenopus laevis XB-GENE-6254406 I 0.849
clock Xenopus tropicalis XB-GENE-495448 I 0.849