CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Gcm1
(
Rattus norvegicus
)
GCM
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF03615 (GCM)
IPR003902
ENSRNOG00000007932
T198053_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including cell differentiation involved in embryonic placenta development; regulation of cell differentiation involved in embryonic placenta development; and transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including astrocyte fate commitment; branching involved in labyrinthine layer morphogenesis; and positive regulation of syncytium formation by plasma membrane fusion. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Gcm1
M02022_2.00
Rattus norvegicus
NNRTRVGGGY
RCCCBYAYNN
PBM
Weirauch et al.(2014)
pTH9283
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Gcm1
M00168_2.00
Mus musculus
NVTRVGGGY
RCCCBYABN
PBM
Badis et al.(2009)
Gcm1_3732
0.993
0.993
GCM1
M02020_2.00
Homo sapiens
NVTVNGGGN
NCCCNBABN
PBM
Weirauch et al.(2014)
pTH7965
0.928
0.928
GCM1
M03068_2.00
Homo sapiens
BATGCGGGTR
YACCCGCATV
SELEX
Jolma et al.(2013)
GCM1_1
0.928
0.928
GCM1
M03069_2.00
Homo sapiens
RTRYKGGYRCCMGYAN
NTRCKGGYRCCMRYAY
SELEX
Jolma et al.(2013)
GCM1_2
0.928
0.928
GCM1
M03070_2.00
Homo sapiens
BATGCGGGTRS
SYACCCGCATV
SELEX
Jolma et al.(2013)
GCM1_3
0.928
0.928
GCM1
M04883_2.00
Homo sapiens
RTGSGGGBV
BVCCCSCAY
SELEX
Yin et al.(2017)
GCM1_eDBD_HT-SELEX
0.928
0.928
GCM1
M05868_2.00
Homo sapiens
ATGCGGGYV
BRCCCGCAT
SMiLE-seq
Isakova et al.(2017)
GCM1
0.928
0.928
GCM1
M10603_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCMA_Q4
0.928
0.928
GCM1
M10604_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCM_Q2
0.928
0.928
GCM1
M04884_2.00
Homo sapiens
ATRNKGGYV
BRCCMNYAT
SELEX
Yin et al.(2017)
GCM1_eDBD_Methyl-HT-SELEX
0.928
0.928
XP_004449939.1
M02027_2.00
Dasypus novemcinctus
RTRSGGGY
RCCCSYAY
PBM
Weirauch et al.(2014)
pTH9259
0.906
0.906
GCM1
M02021_2.00
Meleagris gallopavo
VTVNKGGYNN
NNRCCMNBAB
PBM
Weirauch et al.(2014)
pTH8653
0.884
0.884
GCM2
M02023_2.00
Taeniopygia guttata
NRTRHKGGYN
NRCCMDYAYN
PBM
Weirauch et al.(2014)
pTH9341
0.746
0.746
ENSTRUG00000003586
M02025_2.00
Takifugu rubripes
NRTRNGGGYN
NRCCCNYAYN
PBM
Weirauch et al.(2014)
pTH9357
0.717
0.717
GCM2
M03067_2.00
Homo sapiens
NATGCGGGYD
HRCCCGCATN
SELEX
Jolma et al.(2013)
GCM2_1
0.710
0.710
GCM2
M04881_2.00
Homo sapiens
RTGCGGGYN
NRCCCGCAY
SELEX
Yin et al.(2017)
GCM2_FL_HT-SELEX
0.710
0.710
GCM2
M10602_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCMB_Q2
0.710
0.710
GCM2
M04882_2.00
Homo sapiens
ATRHKGGYN
NRCCMDYAT
SELEX
Yin et al.(2017)
GCM2_FL_Methyl-HT-SELEX
0.710
0.710
gcm2
M02024_2.00
Tetraodon nigroviridis
ATRCGGGY
RCCCGYAT
PBM
Weirauch et al.(2014)
pTH9386
0.703
0.703
gcm2
M02026_2.00
Drosophila melanogaster
ATGCGGGY
RCCCGCAT
PBM
Weirauch et al.(2014)
pTH8361
0.616
0.616
gcm2
M03767_2.00
Drosophila melanogaster
NATGCGGGYNNNRCCCGCATN
NATGCGGGYNNNRCCCGCATN
SELEX
Nitta et al.(2015)
gcm2_1
0.616
0.616
gcm2
M03768_2.00
Drosophila melanogaster
BATGCKGGTACCMGCATV
BATGCKGGTACCMGCATV
SELEX
Nitta et al.(2015)
gcm2_2
0.616
0.616
For this family, TFs with SR scores >
0.607
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M02022_2.00
GCM
30
167
TDWFQEWPDSYVKHIYSSDDRSAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARR
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000010583
GCM
30
167
TDWFQEWPDSYVKHIYSSDDRSAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARR
Links
Other
GCM
family TFs
Other
Rattus norvegicus
TFs
176 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy