Myb (Mus musculus)
Myb/SANT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00249 (Myb_DNA-binding) IPR014778 ENSMUSG00000019982 T269782_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to cytokine stimulus; embryonic digestive tract development; and hematopoietic or lymphoid organ development. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study essential thrombocythemia and myelofibrosis. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Myb
M00179_2.00		 Mus musculus
HAACGGHHNN
NNDDCCGTTD		 PBM
Badis et al.(2009)
Myb_1047		 (Direct) (Direct)
Myb
M09261_2.00		 Mus musculus
NYAACKGHHNBN
NVNDDCMGTTRN		 Misc
Kulakovskiy et al.(2013)
MYB_MOUSE.H11MO.0.A		 (Direct) (Direct)
Myb
M09601_2.00		 Mus musculus
YAACBGYC
GRCVGTTR		 Misc
Heinz et al.(2010)
ERMYB-Myb_GSE22095		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MYB
M08150_2.00 		Homo sapiens
NNCAACTGHN
NDCAGTTGNN		 ChIP-seq
Mathelier et al.(2014)
MA0100.3 		0.909 1.000
MYB
M09260_2.00 		Homo sapiens
NYAACKGYYDNH
DNHRRCMGTTRN		 Misc
Kulakovskiy et al.(2013)
MYB_HUMAN.H11MO.0.A 		0.909 1.000
MYB
M11050_2.00 		Homo sapiens
CMVNCAACBGYCNBYNBV
BVNRVNGRCVGTTGNBKG		 Transfac
Matys et al.(2006)
V$CMYB_01 		0.909 1.000
MYB
M11051_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CMYB_Q5 		0.909 1.000
MYB
M11052_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MYB_Q3 		0.909 1.000
MYB
M11053_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MYB_Q4 		0.909 1.000
MYB
M11054_2.00 		Homo sapiens
VNNAACKDBB
VVHMGTTNNB		 Transfac
Matys et al.(2006)
V$MYB_Q6 		0.909 1.000
Mybl1
M00180_2.00 		Mus musculus
HAACBGHHN
NDDCVGTTD		 PBM
Badis et al.(2009)
Mybl1_1717 		0.832 0.879
MYBL1
M03349_2.00 		Homo sapiens
BVGTTKAACBGY
RCVGTTMAACBV		 SELEX
Jolma et al.(2013)
MYBL1_1 		0.832 0.879
MYBL1
M03350_2.00 		Homo sapiens
RMVGTTAACGGT
ACCGTTAACBKY		 SELEX
Jolma et al.(2013)
MYBL1_2 		0.832 0.879
MYBL1
M03351_2.00 		Homo sapiens
NHRACCGTTWN
NWAACGGTYDN		 SELEX
Jolma et al.(2013)
MYBL1_3 		0.832 0.879
MYBL1
M03352_2.00 		Homo sapiens
HAACSGHHHHAACBGHC
GDCVGTTDDDDCSGTTD		 SELEX
Jolma et al.(2013)
MYBL1_4 		0.832 0.879
Mybl1
M09262_2.00 		Mus musculus
BBNBYAACBGCCNSB
VSNGGCVGTTRVNVV		 Misc
Kulakovskiy et al.(2013)
MYBA_MOUSE.H11MO.0.C 		0.832 0.879
MYB_AVIMB
M11068_2.00 		Avian myeloblastosis virus
VRYAACKGNH
DNCMGTTRYB		 Transfac
Matys et al.(2006)
V$VMYB_01 		0.689 0.750
MYB_AVIMB
M11069_2.00 		Avian myeloblastosis virus
BVYAACGGH
DCCGTTRBV		 Transfac
Matys et al.(2006)
V$VMYB_02 		0.689 0.750
For this family, TFs with SR scores > 0.661 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00179_2.00 Myb 17 63
M00179_2.00 Myb 69 115
M00179_2.00 Myb 121 166

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000020158 Myb 40 86
ENSMUSP00000020158 Myb 92 138
ENSMUSP00000020158 Myb 144 189
ENSMUSP00000139699 Myb 40 86
ENSMUSP00000139699 Myb 92 138
ENSMUSP00000139699 Myb 144 189

Links

Other Myb/SANT family TFs
Other Mus musculus TFs

154 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSOARG00000014901 Ovis aries ENSOARG00000014901 I 0.909
MYB Felis catus ENSFCAG00000001812 I 0.909
MYB Homo sapiens ENSG00000118513 D 0.909
MYB Erinaceus europaeus ENSEEUG00000001468 I 0.909
MYB Sus scrofa ENSSSCG00000004167 I 0.909
MYB Oryctolagus cuniculus ENSOCUG00000011633 I 0.909
ENSSTOG00000007581 Ictidomys tridecemlineatus ENSSTOG00000007581 I 0.909
MYB Dasypus novemcinctus ENSDNOG00000047370 I 0.909
MYB Sorex araneus ENSSARG00000002855 I 0.909
ENSNLEG00000014751 Nomascus leucogenys ENSNLEG00000014751 I 0.909
MYB Loxodonta africana ENSLAFG00000018350 I 0.909
MYB Microcebus murinus ENSMICG00000005531 I 0.909
Myotis_brandtii_MYB_10035701 Myotis brandtii Myotis_brandtii_MYB_10035701 I 0.909
MYB Pan troglodytes ENSPTRG00000018631 I 0.909
MYB Myotis lucifugus ENSMLUG00000002125 I 0.909
MYB Pteropus vampyrus ENSPVAG00000007652 I 0.909
MYB Macaca mulatta ENSMMUG00000018166 I 0.909
ENSCSAG00000016815 Chlorocebus sabaeus ENSCSAG00000016815 I 0.909
MYB Equus caballus ENSECAG00000009918 I 0.909
ENSP00000339992-D1 Bos grunniens ENSP00000339992-D1 I 0.909
MYB Canis familiaris ENSCAFG00000000230 I 0.909
MYB Tursiops truncatus ENSTTRG00000003718 I 0.909
MYB Procavia capensis ENSPCAG00000009197 I 0.909
ENSPANG00000018932 Papio anubis ENSPANG00000018932 I 0.909
MYB Ochotona princeps ENSOPRG00000013639 I 0.909
ENSAMEG00000009813 Ailuropoda melanoleuca ENSAMEG00000009813 I 0.909
ENSP00000339992 Macaca fascicularis ENSP00000339992 I 0.909
MYB Choloepus hoffmanni ENSCHOG00000010472 I 0.909
MYB Bos taurus ENSBTAG00000012074 I 0.909
ENSTSYG00000014301 Tarsius syrichta ENSTSYG00000014301 I 0.909
MYB Cavia porcellus ENSCPOG00000014607 I 0.909
MYB Otolemur garnettii ENSOGAG00000000056 I 0.909
ENSMPUG00000014814 Mustela putorius furo ENSMPUG00000014814 I 0.905
MYB Monodelphis domestica ENSMODG00000017488 I 0.903
MYB Callithrix jacchus ENSCJAG00000007798 I 0.903
MYB Ornithorhynchus anatinus ENSOANG00000002777 I 0.903
ENSSHAG00000014728 Sarcophilus harrisii ENSSHAG00000014728 I 0.903
Brh_R005747 Buceros rhinoceros Brh_R005747 I 0.898
Alligator_sinensis_CCG012608.1 Alligator sinensis Alligator_sinensis_CCG012608.1 I 0.898
Cmyd_10011933 Chelonia mydas Cmyd_10011933 I 0.898
ENSPSIG00000011892 Pelodiscus sinensis ENSPSIG00000011892 I 0.898
Afo_R014904 Aptenodytes forsteri Afo_R014904 I 0.898
MYB Meleagris gallopavo ENSMGAG00000013053 I 0.898
MYB Taeniopygia guttata ENSTGUG00000011495 I 0.898
Tal_R007653 Tyto alba Tal_R007653 I 0.898
Pvit_17294 Pogona vitticeps Pvit_17294 I 0.898
MYB Anolis carolinensis ENSACAG00000009861 I 0.898
Aan_R009776 Calypte anna Aan_R009776 I 0.898
ENSFALG00000011914 Ficedula albicollis ENSFALG00000011914 I 0.898
ENSAPLG00000007728 Anas platyrhynchos ENSAPLG00000007728 I 0.898
MYB Gallus gallus ENSGALG00000013956 I 0.895
myb Xenopus tropicalis XB-GENE-867553 I 0.895
ENSLACG00000002813 Latimeria chalumnae ENSLACG00000002813 I 0.895
XP_002935855 Xenopus tropicalis XP_002935855 I 0.895
MYB Tupaia belangeri ENSTBEG00000016454 I 0.893
Gfo_R006432 Geospiza fortis Gfo_R006432 I 0.893
Myb Rattus norvegicus ENSRNOG00000055858 I 0.885
ENSPPYG00000017028 Pongo abelii ENSPPYG00000017028 I 0.877
ENSLACG00000011097 Latimeria chalumnae ENSLACG00000011097 I 0.858
ENSLOCG00000016218 Lepisosteus oculatus ENSLOCG00000016218 I 0.855
Ogr08782 Ophisaurus gracilis Ogr08782 I 0.853
myb.S Xenopus laevis XB-GENE-867566 I 0.847
Alligator_sinensis_CCG001232.1 Alligator sinensis Alligator_sinensis_CCG001232.1 I 0.838
Ogr00471 Ophisaurus gracilis Ogr00471 I 0.833
Pvit_15001 Pogona vitticeps Pvit_15001 I 0.833
MYBL1 Anolis carolinensis ENSACAG00000016577 I 0.833
MYBL1 Pan troglodytes ENSPTRG00000020308 I 0.832
MYBL1 Vicugna pacos ENSVPAG00000004194 I 0.832
MYBL1 Tursiops truncatus ENSTTRG00000017138 I 0.832
ENSSHAG00000010559 Sarcophilus harrisii ENSSHAG00000010559 I 0.832
Mybl1 Rattus norvegicus ENSRNOG00000021669 I 0.832
ENSPPYG00000018640 Pongo abelii ENSPPYG00000018640 I 0.832
MYBL1 Sorex araneus ENSSARG00000006938 I 0.832
ENSSTOG00000006634 Ictidomys tridecemlineatus ENSSTOG00000006634 I 0.832
ENSPSIG00000011935 Pelodiscus sinensis ENSPSIG00000011935 I 0.832
MYBL1 Monodelphis domestica ENSMODG00000007964 I 0.832
MYBL1 Homo sapiens ENSG00000185697 D 0.832
MYBL1 Equus caballus ENSECAG00000015959 I 0.832
MYBL1 Gorilla gorilla ENSGGOG00000003892 I 0.832
Myotis_brandtii_MYBL1_10031628 Myotis brandtii Myotis_brandtii_MYBL1_10031628 I 0.832
MYBL1 Loxodonta africana ENSLAFG00000004821 I 0.832
MYBL1 Dasypus novemcinctus ENSDNOG00000016860 I 0.832
ENSCSAG00000014195 Chlorocebus sabaeus ENSCSAG00000014195 I 0.832
ENSAMEG00000012401 Ailuropoda melanoleuca ENSAMEG00000012401 I 0.832
MYBL1 Canis familiaris ENSCAFG00000007344 I 0.832
MYBL1 Callithrix jacchus ENSCJAG00000004466 I 0.832
MYBL1 Cavia porcellus ENSCPOG00000007578 I 0.832
MYBL1 Myotis lucifugus ENSMLUG00000003166 I 0.832
MYBL1 Felis catus ENSFCAG00000031398 I 0.832
MYBL1 Oryctolagus cuniculus ENSOCUG00000015184 I 0.832
ENSOARG00000017663 Ovis aries ENSOARG00000017663 I 0.832
MYBL1 Otolemur garnettii ENSOGAG00000004344 I 0.832
MYBL1 Ornithorhynchus anatinus ENSOANG00000002308 I 0.832
MYBL1 Macaca mulatta ENSMMUG00000013974 I 0.832
Mybl1 Mus musculus ENSMUSG00000025912 D 0.832
ENSP00000385360 Macaca fascicularis ENSP00000385360 I 0.832
MYBL1 Taeniopygia guttata ENSTGUG00000011289 I 0.828
ENSFALG00000005444 Ficedula albicollis ENSFALG00000005444 I 0.828
Gfo_R002003 Geospiza fortis Gfo_R002003 I 0.828
ENSAMXG00000004244 Astyanax mexicanus ENSAMXG00000004244 I 0.825
Afo_R010364 Aptenodytes forsteri Afo_R010364 I 0.821
ENSAPLG00000014596 Anas platyrhynchos ENSAPLG00000014596 I 0.821
ENSGALG00000015522 Gallus gallus ENSGALG00000015522 I 0.821
Aan_R014924 Calypte anna Aan_R014924 I 0.821
myb Danio rerio ENSDARG00000053666 I 0.819
MYBL1 Echinops telfairi ENSETEG00000009840 I 0.815
mybl1 Danio rerio ENSDARG00000030999 I 0.805
Tal_R003498 Tyto alba Tal_R003498 I 0.805
myb Takifugu rubripes ENSTRUG00000016069 I 0.796
myb Tetraodon nigroviridis ENSTNIG00000016319 I 0.796
Brh_R006445 Buceros rhinoceros Brh_R006445 I 0.785
ENSXMAG00000004392 Xiphophorus maculatus ENSXMAG00000004392 I 0.783
myb Oryzias latipes ENSORLG00000016573 I 0.783
mybl1 Takifugu rubripes ENSTRUG00000008816 I 0.783
ENSONIG00000000469 Oreochromis niloticus ENSONIG00000000469 I 0.783
ENSPFOG00000011241 Poecilia formosa ENSPFOG00000011241 I 0.783
ENSLOCG00000004709 Lepisosteus oculatus ENSLOCG00000004709 I 0.781
mybl1 Oryzias latipes ENSORLG00000008488 I 0.775
ENSPFOG00000005169 Poecilia formosa ENSPFOG00000005169 I 0.775
mybl1 Tetraodon nigroviridis ENSTNIG00000010104 I 0.775
ENSXMAG00000001658 Xiphophorus maculatus ENSXMAG00000001658 I 0.775
ENSGMOG00000011856 Gadus morhua ENSGMOG00000011856 I 0.773
ENSPMAG00000001639 Petromyzon marinus ENSPMAG00000001639 I 0.770
ENSAMXG00000013759 Astyanax mexicanus ENSAMXG00000013759 I 0.766
ENSONIG00000014188 Oreochromis niloticus ENSONIG00000014188 I 0.766
myb Gasterosteus aculeatus ENSGACG00000011054 I 0.759
mybl1 Xenopus tropicalis XB-GENE-986560 I 0.751
ENSPMAG00000000117 Petromyzon marinus ENSPMAG00000000117 I 0.750
estExt_fgenesh2_pg.C_1220090 Branchiostoma floridae estExt_fgenesh2_pg.C_1220090 I 0.749
estExt_fgenesh2_pg.C_1220082 Branchiostoma floridae estExt_fgenesh2_pg.C_1220082 I 0.749
ENSGMOG00000017106 Gadus morhua ENSGMOG00000017106 I 0.745
mybl1 Gasterosteus aculeatus ENSGACG00000002964 I 0.734
MYB Gorilla gorilla ENSGGOG00000001379 I 0.731
ENSMEUG00000010838 Macropus eugenii ENSMEUG00000010838 I 0.727
MYBL1 Procavia capensis ENSPCAG00000009301 I 0.727
Sakowv30034766m.g Saccoglossus kowalevskii Sakowv30034766m.g I 0.726
SMAR001262 Strigamia maritima SMAR001262 I 0.726
MYBL1 Microcebus murinus ENSMICG00000009881 I 0.725
ENSPANG00000008051 Papio anubis ENSPANG00000008051 I 0.720
mybl1.L Xenopus laevis XB-GENE-986561 I 0.709
ENSCING00000018880 Ciona intestinalis ENSCING00000018880 I 0.693
MYB_AVIMB Avian myeloblastosis virus MYB_AVIMB D 0.689
ENSLACG00000018995 Latimeria chalumnae ENSLACG00000018995 I 0.686
MYBL1 Bos taurus ENSBTAG00000011981 I 0.683
MYBL1 Choloepus hoffmanni ENSCHOG00000012311 I 0.683
Cflo_09641--XP_393231.3_APIME Camponotus floridanus Cflo_09641--XP_393231.3_APIME I 0.673
MYBL1 Ochotona princeps ENSOPRG00000005971 I 0.669
NEMVEDRAFT_v1g38726 Nematostella vectensis NEMVEDRAFT_v1g38726 I 0.667
GB44791 Apis mellifera GB44791 I 0.666
Cmyd_10015187 Chelonia mydas Cmyd_10015187 I 0.662
Alligator_sinensis_CCG014289.1 Alligator sinensis Alligator_sinensis_CCG014289.1 I 0.662
ENSPSIG00000016162 Pelodiscus sinensis ENSPSIG00000016162 I 0.662
XP_002166953.1 Hydra magnipapillata XP_002166953.1 I 0.661