ovo (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0003028 T114405_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity and transcription coactivator binding activity. Involved in several processes, including adult feeding behavior; regionalization; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including cephalic furrow; extended germ band embryo; gonad; head segment; and integumentary system. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to several human genes including OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ovo
M02671_2.00		 Drosophila melanogaster
DCNGTTWSD
HSWAACNGH		 SELEX
Mathelier et al.(2014)
MA0126.1		 (Direct) (Direct)
ovo
M03669_2.00		 Drosophila melanogaster
DNMCCGTTA
TAACGGKNH		 SELEX
Nitta et al.(2015)
ovo_1		 (Direct) (Direct)
ovo
M06064_2.00		 Drosophila melanogaster
CHGTTAHW
WDTAACDG		 B1H
Zhu et al.(2011)
ovo_FlyReg_FBgn0003028		 (Direct) (Direct)
ovo
M06065_2.00		 Drosophila melanogaster
RGTHCCGTTAT
ATAACGGDACY		 B1H
Zhu et al.(2011)
ovo_SANGER_5_FBgn0003028		 (Direct) (Direct)
ovo
M06066_2.00		 Drosophila melanogaster
DDTMCCGTTABNYN
NRNVTAACGGKAHH		 B1H
Zhu et al.(2011)
ovo_SOLEXA_5_FBgn0003028		 (Direct) (Direct)
ovo
M09662_2.00		 Drosophila melanogaster
DCNGTTAMWNNDV
BHNNWKTAACNGH		 Misc
Kulakovskiy et al.(2009)
ovo		 (Direct) (Direct)
ovo
M10373_2.00		 Drosophila melanogaster
NNNDCNGTTWSDDNN
NNHHSWAACNGHNNN		 Transfac
Matys et al.(2006)
I$OVO_01		 (Direct) (Direct)
ovo
M10374_2.00		 Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$OVO_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
lin-48
M00614_2.00 		Caenorhabditis elegans
HCCGTTAB
VTAACGGD		 PBM
Narasimhan et al.(2015)
pTH9155 		0.790 0.826
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0070706 C2H2 ZF 1197 1219
FBpp0070706 C2H2 ZF 1225 1247
FBpp0070706 C2H2 ZF 1253 1276
FBpp0070707 C2H2 ZF 1068 1090
FBpp0070707 C2H2 ZF 1096 1118
FBpp0070707 C2H2 ZF 1124 1147
FBpp0070708 C2H2 ZF 821 843
FBpp0070708 C2H2 ZF 849 871
FBpp0070708 C2H2 ZF 877 900
FBpp0099822 C2H2 ZF 874 896
FBpp0099822 C2H2 ZF 902 924
FBpp0099822 C2H2 ZF 930 953
FBpp0291128 C2H2 ZF 1197 1219
FBpp0291128 C2H2 ZF 1225 1247
FBpp0291128 C2H2 ZF 1253 1276

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GH24684 Drosophila grimshawi FBgn0132140 I 0.827
GG18741 Drosophila erecta FBgn0110950 I 0.827
GF20355 Drosophila ananassae FBgn0097362 I 0.827
ovo Drosophila virilis FBgn0064309 I 0.827
GI21666 Drosophila mojavensis FBgn0144396 I 0.827
GM12381 Drosophila sechellia FBgn0167318 I 0.827
GA22634 Drosophila pseudoobscura FBgn0244037 I 0.827
GE16381 Drosophila yakuba FBgn0233910 I 0.827
GK10250 Drosophila willistoni FBgn0212265 I 0.827
GD24377 Drosophila simulans FBgn0195718 I 0.827
GL26817 Drosophila persimilis FBgn0164398 I 0.827
BGIBMGA000988 Bombyx mori BGIBMGA000988 I 0.821
KGM_02259 Danaus plexippus KGM_02259 I 0.821
MCINX009401 Melitaea cinxia MCINX009401 I 0.821
AATE002741 Anopheles atroparvus AATE002741 I 0.817
AMEC022552 Anopheles melas AMEC022552 I 0.817
AAEL017521 Aedes aegypti AAEL017521 I 0.817
ADIR001008 Anopheles dirus ADIR001008 I 0.817
ACUA027175 Anopheles culicifacies ACUA027175 I 0.817
ACHR004136 Anopheles christyi ACHR004136 I 0.817
ADAC004491 Anopheles darlingi ADAC004491 I 0.817
HMEL006827 Heliconius melpomene HMEL006827 I 0.817
AGAP000114 Anopheles gambiae AGAP000114 I 0.817
ASIS014406 Anopheles sinensis ASIS014406 I 0.817
AMEM014020 Anopheles merus AMEM014020 I 0.817
AFUN010393 Anopheles funestus AFUN010393 I 0.817
LCUP004963 Lucilia cuprina LCUP004963 I 0.817
ASTEI07557 Anopheles stephensi ASTEI07557 I 0.817
AARA001055 Anopheles arabiensis AARA001055 I 0.817
PPAI008669 Phlebotomus papatasi PPAI008669 I 0.817
ACEP17857 Atta cephalotes ACEP17857 I 0.808
Cflo_08035--XP_624482.2_APIME Camponotus floridanus Cflo_08035--XP_624482.2_APIME I 0.808
SINV17081 Solenopsis invicta SINV17081 I 0.808
GB51354 Apis mellifera GB51354 I 0.805
PHUM086430 Pediculus humanus PHUM086430 I 0.805
CpipJ_CPIJ018505 Culex pipiens CpipJ_CPIJ018505 I 0.801
L798_11303 Zootermopsis nevadensis L798_11303 I 0.801
CPIJ018505 Culex quinquefasciatus CPIJ018505 I 0.801
HHAL005991-PA Halyomorpha halys HHAL005991-PA I 0.797
CLEC002514 Cimex lectularius CLEC002514 I 0.797
MDOA012259 Musca domestica MDOA012259 I 0.797
NECAME_03083 Necator americanus NECAME_03083 I 0.797
LDEC009536 Leptinotarsa decemlineata LDEC009536 I 0.797
RPRC002781 Rhodnius prolixus RPRC002781 I 0.797
TC008099 Tribolium castaneum TC008099 I 0.797
ACYPI003064 Acyrthosiphon pisum ACYPI003064 I 0.797
CapteG147941 Capitella teleta CapteG147941 I 0.794
ISCW013547 Ixodes scapularis ISCW013547 I 0.794
BTMF_0001741201 Brugia timori BTMF_0001741201 I 0.793
Bm3814 Brugia malayi Bm3814 I 0.793
L898_g2421 Steinernema monticolum L898_g2421 I 0.793
HCOI01936300 Haemonchus contortus HCOI01936300 I 0.793
TELCIR_07985 Teladorsagia circumcincta TELCIR_07985 I 0.793
CJA03277 Caenorhabditis japonica CJA03277 I 0.790
CBG09216 Caenorhabditis briggsae CBG09216 I 0.790
CJA37604 Caenorhabditis japonica CJA37604 I 0.790
CBN00506 Caenorhabditis brenneri CBN00506 I 0.790
CRE25436 Caenorhabditis remanei CRE25436 I 0.790
lin-48 Caenorhabditis elegans WBGene00003033 D 0.790
SMAR006131 Strigamia maritima SMAR006131 I 0.778
SBAD_0001064501 Soboliphyme baturini SBAD_0001064501 I 0.777
tetur12g02770 Tetranychus urticae tetur12g02770 I 0.777
SPU_012448 Strongylocentrotus purpuratus SPU_012448 I 0.774
tetur12g02860 Tetranychus urticae tetur12g02860 I 0.774
tetur12g02760 Tetranychus urticae tetur12g02760 I 0.773
tetur12g02740 Tetranychus urticae tetur12g02740 I 0.773
Sakowv30033343m.g Saccoglossus kowalevskii Sakowv30033343m.g I 0.770
tetur12g02810 Tetranychus urticae tetur12g02810 I 0.770
tetur157g00030 Tetranychus urticae tetur157g00030 I 0.766