lin-48 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00003033 T131560_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hindgut morphogenesis and nematode male tail tip morphogenesis. Located in nucleus. Is expressed in ciliated neurons; interfacial epithelial cell; intestine; labial sensillum; and tail. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to several human genes including OVOL1 (ovo like transcriptional repressor 1) and OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
lin-48
M00614_2.00		 Caenorhabditis elegans
HCCGTTAB
VTAACGGD		 PBM
Narasimhan et al.(2015)
pTH9155		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ovo
M03669_2.00 		Drosophila melanogaster
DNMCCGTTA
TAACGGKNH		 SELEX
Nitta et al.(2015)
ovo_1 		0.790 0.826
ovo
M06064_2.00 		Drosophila melanogaster
CHGTTAHW
WDTAACDG		 B1H
Zhu et al.(2011)
ovo_FlyReg_FBgn0003028 		0.790 0.826
ovo
M06065_2.00 		Drosophila melanogaster
RGTHCCGTTAT
ATAACGGDACY		 B1H
Zhu et al.(2011)
ovo_SANGER_5_FBgn0003028 		0.790 0.826
ovo
M06066_2.00 		Drosophila melanogaster
DDTMCCGTTABNYN
NRNVTAACGGKAHH		 B1H
Zhu et al.(2011)
ovo_SOLEXA_5_FBgn0003028 		0.790 0.826
ovo
M02671_2.00 		Drosophila melanogaster
DCNGTTWSD
HSWAACNGH		 SELEX
Mathelier et al.(2014)
MA0126.1 		0.790 0.826
ovo
M09662_2.00 		Drosophila melanogaster
DCNGTTAMWNNDV
BHNNWKTAACNGH		 Misc
Kulakovskiy et al.(2009)
ovo 		0.790 0.826
ovo
M10373_2.00 		Drosophila melanogaster
NNNDCNGTTWSDDNN
NNHHSWAACNGHNNN		 Transfac
Matys et al.(2006)
I$OVO_01 		0.790 0.826
ovo
M10374_2.00 		Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$OVO_Q6 		0.790 0.826
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00614_2.00 C2H2 ZF 51 73
M00614_2.00 C2H2 ZF 79 101
M00614_2.00 C2H2 ZF 107 130

DNA Binding Domains

Protein ID Domain From To Sequence
F34D10.5 C2H2 ZF 133 155
F34D10.5 C2H2 ZF 161 183
F34D10.5 C2H2 ZF 189 212

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CJA37604 Caenorhabditis japonica CJA37604 I 0.827
CJA03277 Caenorhabditis japonica CJA03277 I 0.827
CBG09216 Caenorhabditis briggsae CBG09216 I 0.827
CRE25436 Caenorhabditis remanei CRE25436 I 0.827
Bm3814 Brugia malayi Bm3814 I 0.820
BTMF_0001741201 Brugia timori BTMF_0001741201 I 0.820
CBN00506 Caenorhabditis brenneri CBN00506 I 0.811
HHAL005991-PA Halyomorpha halys HHAL005991-PA I 0.809
CLEC002514 Cimex lectularius CLEC002514 I 0.809
RPRC002781 Rhodnius prolixus RPRC002781 I 0.809
HCOI01936300 Haemonchus contortus HCOI01936300 I 0.808
TELCIR_07985 Teladorsagia circumcincta TELCIR_07985 I 0.808
ACEP17857 Atta cephalotes ACEP17857 I 0.806
SINV17081 Solenopsis invicta SINV17081 I 0.806
Cflo_08035--XP_624482.2_APIME Camponotus floridanus Cflo_08035--XP_624482.2_APIME I 0.806
GB51354 Apis mellifera GB51354 I 0.806
NECAME_03083 Necator americanus NECAME_03083 I 0.804
L898_g2421 Steinernema monticolum L898_g2421 I 0.800
CapteG147941 Capitella teleta CapteG147941 I 0.796
TC008099 Tribolium castaneum TC008099 I 0.794
AAEL017521 Aedes aegypti AAEL017521 I 0.794
PPAI008669 Phlebotomus papatasi PPAI008669 I 0.794
LCUP004963 Lucilia cuprina LCUP004963 I 0.794
ADIR001008 Anopheles dirus ADIR001008 I 0.794
AFUN010393 Anopheles funestus AFUN010393 I 0.794
AMEC022552 Anopheles melas AMEC022552 I 0.794
AMEM014020 Anopheles merus AMEM014020 I 0.794
ACUA027175 Anopheles culicifacies ACUA027175 I 0.794
ACHR004136 Anopheles christyi ACHR004136 I 0.794
LDEC009536 Leptinotarsa decemlineata LDEC009536 I 0.794
ASTEI07557 Anopheles stephensi ASTEI07557 I 0.794
AARA001055 Anopheles arabiensis AARA001055 I 0.794
AATE002741 Anopheles atroparvus AATE002741 I 0.794
ASIS014406 Anopheles sinensis ASIS014406 I 0.794
CpipJ_CPIJ018505 Culex pipiens CpipJ_CPIJ018505 I 0.794
ADAC004491 Anopheles darlingi ADAC004491 I 0.794
CPIJ018505 Culex quinquefasciatus CPIJ018505 I 0.794
HMEL006827 Heliconius melpomene HMEL006827 I 0.794
AGAP000114 Anopheles gambiae AGAP000114 I 0.794
GH24684 Drosophila grimshawi FBgn0132140 I 0.790
GI21666 Drosophila mojavensis FBgn0144396 I 0.790
GL26817 Drosophila persimilis FBgn0164398 I 0.790
GG18741 Drosophila erecta FBgn0110950 I 0.790
ovo Drosophila virilis FBgn0064309 I 0.790
BGIBMGA000988 Bombyx mori BGIBMGA000988 I 0.790
ovo Drosophila melanogaster FBgn0003028 D 0.790
GM12381 Drosophila sechellia FBgn0167318 I 0.790
GF20355 Drosophila ananassae FBgn0097362 I 0.790
ACYPI003064 Acyrthosiphon pisum ACYPI003064 I 0.790
ISCW013547 Ixodes scapularis ISCW013547 I 0.790
KGM_02259 Danaus plexippus KGM_02259 I 0.790
L798_11303 Zootermopsis nevadensis L798_11303 I 0.790
MCINX009401 Melitaea cinxia MCINX009401 I 0.790
PHUM086430 Pediculus humanus PHUM086430 I 0.790
GA22634 Drosophila pseudoobscura FBgn0244037 I 0.790
GE16381 Drosophila yakuba FBgn0233910 I 0.790
GD24377 Drosophila simulans FBgn0195718 I 0.790
GK10250 Drosophila willistoni FBgn0212265 I 0.790
SMAR006131 Strigamia maritima SMAR006131 I 0.786
MDOA012259 Musca domestica MDOA012259 I 0.774
tetur12g02740 Tetranychus urticae tetur12g02740 I 0.774
SPU_012448 Strongylocentrotus purpuratus SPU_012448 I 0.774
tetur12g02760 Tetranychus urticae tetur12g02760 I 0.774
tetur12g02810 Tetranychus urticae tetur12g02810 I 0.774
tetur157g00030 Tetranychus urticae tetur157g00030 I 0.774
Sakowv30033343m.g Saccoglossus kowalevskii Sakowv30033343m.g I 0.770
tetur12g02770 Tetranychus urticae tetur12g02770 I 0.770
tetur12g02860 Tetranychus urticae tetur12g02860 I 0.770
SMU15000684 Schmidtea mediterranea SMU15000684 I 0.763
SBAD_0001064501 Soboliphyme baturini SBAD_0001064501 I 0.761