nhr-183 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00018266 T306344_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in head neurons; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-182
M00701_2.00 		Caenorhabditis elegans
DWBYGTGWCH
DGWCACRVWH		 PBM
Narasimhan et al.(2015)
pTH10779 		0.949 0.614
nhr-182
M00702_2.00 		Caenorhabditis elegans
NNNHRTRNHN
NDNYAYDNNN		 PBM
Narasimhan et al.(2015)
pTH6106 		0.949 0.614
CBG01250
M02391_2.00 		Caenorhabditis briggsae
WBYGTGTC
GACACRVW		 PBM
Weirauch et al.(2014)
pTH6110 		0.804 0.486
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F41B5.10 Nuclear receptor 2 74

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

21 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
nhr-182 Caenorhabditis elegans WBGene00018265 D 0.949
CRE08751 Caenorhabditis remanei CRE08751 I 0.917
CBG01235 Caenorhabditis briggsae CBG01235 I 0.917
CBN15241 Caenorhabditis brenneri CBN15241 I 0.917
CRE08753 Caenorhabditis remanei CRE08753 I 0.885
CJA19466 Caenorhabditis japonica CJA19466 I 0.867
CRE08754 Caenorhabditis remanei CRE08754 I 0.863
CRE08755 Caenorhabditis remanei CRE08755 I 0.854
nhr-190 Caenorhabditis elegans WBGene00018622 I 0.851
WBGene00003673 Caenorhabditis elegans WBGene00003673 I 0.851
CBG06387 Caenorhabditis briggsae CBG06387 I 0.844
CRE14845 Caenorhabditis remanei CRE14845 I 0.843
PEQ_0000560101 Parascaris equorum PEQ_0000560101 I 0.831
nhr-184 Caenorhabditis elegans WBGene00018415 I 0.827
nhr-133 Caenorhabditis elegans WBGene00003723 I 0.812
nhr-130 Caenorhabditis elegans WBGene00003720 I 0.809
CBG01250 Caenorhabditis briggsae CBG01250 D 0.804
CBG01243 Caenorhabditis briggsae CBG01243 I 0.780
CBG19144 Caenorhabditis briggsae CBG19144 I 0.765
ANCCEY_07914 Ancylostoma ceylanicum ANCCEY_07914 I 0.753
CBG17906 Caenorhabditis briggsae CBG17906 I 0.746