nhr-133 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003723 T306245_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including coelomocyte; excretory cell; neurons; rectal gland cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-182
M00701_2.00 		Caenorhabditis elegans
DWBYGTGWCH
DGWCACRVWH		 PBM
Narasimhan et al.(2015)
pTH10779 		0.902 0.557
nhr-182
M00702_2.00 		Caenorhabditis elegans
NNNHRTRNHN
NDNYAYDNNN		 PBM
Narasimhan et al.(2015)
pTH6106 		0.902 0.557
CBG01250
M02391_2.00 		Caenorhabditis briggsae
WBYGTGTC
GACACRVW		 PBM
Weirauch et al.(2014)
pTH6110 		0.863 0.586
nhr-232
M00700_2.00 		Caenorhabditis elegans
NNTNTDWYN
NRWHANANN		 PBM
Narasimhan et al.(2015)
pTH10647 		0.753 0.471
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F44C8.8 Nuclear receptor 9 78

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

34 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE08754 Caenorhabditis remanei CRE08754 I 0.939
nhr-190 Caenorhabditis elegans WBGene00018622 I 0.932
CRE08753 Caenorhabditis remanei CRE08753 I 0.925
WBGene00003673 Caenorhabditis elegans WBGene00003673 I 0.913
nhr-184 Caenorhabditis elegans WBGene00018415 I 0.903
nhr-182 Caenorhabditis elegans WBGene00018265 D 0.902
CRE08755 Caenorhabditis remanei CRE08755 I 0.889
CJA19466 Caenorhabditis japonica CJA19466 I 0.878
nhr-130 Caenorhabditis elegans WBGene00003720 I 0.878
CBG01250 Caenorhabditis briggsae CBG01250 D 0.863
CBG06387 Caenorhabditis briggsae CBG06387 I 0.862
CRE08760 Caenorhabditis remanei CRE08760 I 0.833
CBG15881 Caenorhabditis briggsae CBG15881 I 0.827
nhr-183 Caenorhabditis elegans WBGene00018266 I 0.812
CBG17906 Caenorhabditis briggsae CBG17906 I 0.809
CRE30948 Caenorhabditis remanei CRE30948 I 0.793
CBG17898 Caenorhabditis briggsae CBG17898 I 0.789
CBN03087 Caenorhabditis brenneri CBN03087 I 0.788
CBG01251 Caenorhabditis briggsae CBG01251 I 0.787
CRE08749 Caenorhabditis remanei CRE08749 I 0.775
NBR_0001218401 Nippostrongylus brasiliensis NBR_0001218401 I 0.773
CBG01243 Caenorhabditis briggsae CBG01243 I 0.770
HCOI00483700 Haemonchus contortus HCOI00483700 I 0.768
ANCCEY_13226 Ancylostoma ceylanicum ANCCEY_13226 I 0.768
HPLM_0000277901 Haemonchus placei HPLM_0000277901 I 0.768
SVUK_0002058501 Strongylus vulgaris SVUK_0002058501 I 0.762
CBG01353 Caenorhabditis briggsae CBG01353 I 0.758
CBG09567 Caenorhabditis briggsae CBG09567 I 0.753
nhr-232 Caenorhabditis elegans WBGene00012494 D 0.753
nhr-179 Caenorhabditis elegans WBGene00017512 I 0.751
CRE05044 Caenorhabditis remanei CRE05044 I 0.747
CRE14845 Caenorhabditis remanei CRE14845 I 0.747
L898_g21763 Steinernema monticolum L898_g21763 I 0.746
PEQ_0000560101 Parascaris equorum PEQ_0000560101 I 0.745