nhr-173 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00016975 T306335_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in anatomical structure development; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-49
M02413_2.00 		Caenorhabditis elegans
NNNNWNHAN
NTDNWNNNN		 PBM
Weirauch et al.(2014)
pTH5891 		0.913 0.614
nhr-1
M00686_2.00 		Caenorhabditis elegans
ARTGATCA
TGATCAYT		 PBM
Narasimhan et al.(2015)
pTH9322 		0.848 0.586
nhr-154
M00698_2.00 		Caenorhabditis elegans
NRBRYCAHWD
HWDTGRYVYN		 PBM
Narasimhan et al.(2015)
pTH10650 		0.750 0.614
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
C56E10.1 Nuclear receptor 101 172

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

223 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE00606 Caenorhabditis remanei CRE00606 I 0.994
CBG10857 Caenorhabditis briggsae CBG10857 I 0.994
CJA00680 Caenorhabditis japonica CJA00680 I 0.992
L596_g27472 Steinernema carpocapsae L596_g27472 I 0.982
L892_g17612 Steinernema scapterisci L892_g17612 I 0.981
L889_g1891 Steinernema feltiae L889_g1891 I 0.981
L893_g3565 Steinernema glaseri L893_g3565 I 0.980
L892_g4169 Steinernema scapterisci L892_g4169 I 0.980
ASIM_0001569801 Anisakis simplex ASIM_0001569801 I 0.978
CRE00149 Caenorhabditis remanei CRE00149 I 0.977
CBN24827 Caenorhabditis brenneri CBN24827 I 0.975
CJA08896 Caenorhabditis japonica CJA08896 I 0.975
nhr-120 Caenorhabditis elegans WBGene00003710 I 0.975
CBG10855 Caenorhabditis briggsae CBG10855 I 0.975
PPA24481 Pristionchus pacificus PPA24481 I 0.973
scaffold552-EXSNAP2012.17 Pristionchus exspectatus scaffold552-EXSNAP2012.17 I 0.973
L893_g28857 Steinernema glaseri L893_g28857 I 0.972
L898_g9866 Steinernema monticolum L898_g9866 I 0.967
L889_g1557 Steinernema feltiae L889_g1557 I 0.967
scaffold43-EXSNAP2012.41 Pristionchus exspectatus scaffold43-EXSNAP2012.41 I 0.966
PEQ_0000722401 Parascaris equorum PEQ_0000722401 I 0.966
ASU_03657 Ascaris suum ASU_03657 I 0.966
NECAME_01944 Necator americanus NECAME_01944 I 0.966
NECAME_08394 Necator americanus NECAME_08394 I 0.965
ANCCEY_01254 Ancylostoma ceylanicum ANCCEY_01254 I 0.963
PPA21777 Pristionchus pacificus PPA21777 I 0.963
HPBE_0001246601 Heligmosomoides bakeri HPBE_0001246601 I 0.962
HCOI01292200 Haemonchus contortus HCOI01292200 I 0.961
HPLM_0000769401 Haemonchus placei HPLM_0000769401 I 0.961
HCOI01525900 Haemonchus contortus HCOI01525900 I 0.960
PPA29597 Pristionchus pacificus PPA29597 I 0.959
scaffold572-EXSNAP2012.7 Pristionchus exspectatus scaffold572-EXSNAP2012.7 I 0.959
scaffold384-EXSNAP2012.4 Pristionchus exspectatus scaffold384-EXSNAP2012.4 I 0.959
Ppa-nhr-120 Pristionchus pacificus PPA00183 I 0.959
ANCCAN_09880 Ancylostoma caninum ANCCAN_09880 I 0.959
BTMF_0000941401 Brugia timori BTMF_0000941401 I 0.957
LOAG_16377 Loa loa LOAG_16377 I 0.957
EEL_0000989101 Elaeophora elaphi EEL_0000989101 I 0.956
scaffold426-EXSNAP2012.35 Pristionchus exspectatus scaffold426-EXSNAP2012.35 I 0.954
WBGene00240403 Onchocerca volvulus WBGene00240403 I 0.948
L596_g23863 Steinernema carpocapsae L596_g23863 I 0.940
scaffold605-EXSNAP2012.9 Pristionchus exspectatus scaffold605-EXSNAP2012.9 I 0.935
L893_g13285 Steinernema glaseri L893_g13285 I 0.935
L596_g11035 Steinernema carpocapsae L596_g11035 I 0.934
L889_g17247 Steinernema feltiae L889_g17247 I 0.934
L898_g26357 Steinernema monticolum L898_g26357 I 0.934
scaffold552-EXSNAP2012.18 Pristionchus exspectatus scaffold552-EXSNAP2012.18 I 0.930
HPBE_0000704501 Heligmosomoides bakeri HPBE_0000704501 I 0.928
DME_0000591901 Dracunculus medinensis DME_0000591901 I 0.921
BXY_0599800 Bursaphelenchus xylophilus BXY_0599800 I 0.920
GPLIN_000337500 Globodera pallida GPLIN_000337500 I 0.919
PPA06637 Pristionchus pacificus PPA06637 I 0.917
TCLT_0000461101 Thelazia callipaeda TCLT_0000461101 I 0.915
ASU_03870 Ascaris suum ASU_03870 I 0.913
PEQ_0000391501 Parascaris equorum PEQ_0000391501 I 0.913
GPLIN_001175700 Globodera pallida GPLIN_001175700 I 0.913
CBG03844 Caenorhabditis briggsae CBG03844 I 0.913
CBN20749 Caenorhabditis brenneri CBN20749 I 0.913
CRE08259 Caenorhabditis remanei CRE08259 I 0.913
CBN18198 Caenorhabditis brenneri CBN18198 I 0.913
nhr-49 Caenorhabditis elegans WBGene00003639 D 0.913
LOAG_08615 Loa loa LOAG_08615 I 0.912
scaffold598-EXSNAP2012.5 Pristionchus exspectatus scaffold598-EXSNAP2012.5 I 0.911
BTMF_0000217201 Brugia timori BTMF_0000217201 I 0.910
Bm4980 Brugia malayi Bm4980 I 0.910
SPAL_0001637600 Strongyloides papillosus SPAL_0001637600 I 0.909
SVE_0429000 Strongyloides venezuelensis SVE_0429000 I 0.909
SSTP_0000055100 Strongyloides stercoralis SSTP_0000055100 I 0.909
BXY_1057600 Bursaphelenchus xylophilus BXY_1057600 I 0.908
PTRK_0000994100 Parastrongyloides trichosuri PTRK_0000994100 I 0.907
nOo.2.0.1.g02345 Onchocerca ochengi nOo.2.0.1.g02345 I 0.907
WBGene00236987 Onchocerca volvulus WBGene00236987 I 0.907
EVEC_0001313601 Enterobius vermicularis EVEC_0001313601 I 0.904
scaffold251-EXSNAP2012.44 Pristionchus exspectatus scaffold251-EXSNAP2012.44 I 0.902
scaffold826-EXSNAP2012.10 Pristionchus exspectatus scaffold826-EXSNAP2012.10 I 0.902
DICVIV_00957 Dictyocaulus viviparus DICVIV_00957 I 0.901
HCOI00618700 Haemonchus contortus HCOI00618700 I 0.901
ACAC_0000711701 Angiostrongylus cantonensis ACAC_0000711701 I 0.901
SPAL_0001099500 Strongyloides papillosus SPAL_0001099500 I 0.900
SVE_0858700 Strongyloides venezuelensis SVE_0858700 I 0.900
SSTP_0000769100 Strongyloides stercoralis SSTP_0000769100 I 0.900
PTRK_0001020800 Parastrongyloides trichosuri PTRK_0001020800 I 0.900
Hba_12763 Heterorhabditis bacteriophora Hba_12763 I 0.897
PTRK_0000480700 Parastrongyloides trichosuri PTRK_0000480700 I 0.891
SPAL_0001712900 Strongyloides papillosus SPAL_0001712900 I 0.891
SSTP_0001253400 Strongyloides stercoralis SSTP_0001253400 I 0.891
SVE_0146100 Strongyloides venezuelensis SVE_0146100 I 0.891
PPA10975 Pristionchus pacificus PPA10975 N 0.890
PTRK_0000720500 Parastrongyloides trichosuri PTRK_0000720500 I 0.890
SSTP_0000145700 Strongyloides stercoralis SSTP_0000145700 I 0.890
SVE_1799100 Strongyloides venezuelensis SVE_1799100 I 0.889
SPAL_0000841700 Strongyloides papillosus SPAL_0000841700 I 0.889
augustus_masked-nMf.1.1.scaf06210-processed-gene-0.0 Meloidogyne floridensis augustus_masked-nMf.1.1.scaf06210-processed-gene-0.0 I 0.888
ACAC_0001297301 Angiostrongylus cantonensis ACAC_0001297301 I 0.882
TCLT_0000256201 Thelazia callipaeda TCLT_0000256201 I 0.878
augustus_masked-nMf.1.1.scaf24822-processed-gene-0.0 Meloidogyne floridensis augustus_masked-nMf.1.1.scaf24822-processed-gene-0.0 I 0.875
PPA24468 Pristionchus pacificus PPA24468 I 0.874
scaffold265-EXSNAP2012.2 Pristionchus exspectatus scaffold265-EXSNAP2012.2 I 0.874
SSTP_0000546600 Strongyloides stercoralis SSTP_0000546600 I 0.870
HCOI00601000 Haemonchus contortus HCOI00601000 I 0.867
HPLM_0000564201 Haemonchus placei HPLM_0000564201 I 0.867
nhr-136 Caenorhabditis elegans WBGene00003726 I 0.866
RSKR_0000342500 Rhabditophanes kr3021 RSKR_0000342500 I 0.862
scaffold92-EXSNAP2012.31 Pristionchus exspectatus scaffold92-EXSNAP2012.31 N 0.860
CRE27053 Caenorhabditis remanei CRE27053 I 0.856
CBN29725 Caenorhabditis brenneri CBN29725 I 0.856
PTRK_0001312000 Parastrongyloides trichosuri PTRK_0001312000 I 0.855
ANCCAN_14103 Ancylostoma caninum ANCCAN_14103 I 0.854
ANCCAN_17081 Ancylostoma caninum ANCCAN_17081 I 0.854
BXY_0631600 Bursaphelenchus xylophilus BXY_0631600 I 0.854
L596_g23777 Steinernema carpocapsae L596_g23777 I 0.853
L893_g25227 Steinernema glaseri L893_g25227 I 0.853
ALUE_0002179401 Ascaris lumbricoides ALUE_0002179401 I 0.852
CBN19664 Caenorhabditis brenneri CBN19664 N 0.852
NECAME_00872 Necator americanus NECAME_00872 I 0.852
ASU_12501 Ascaris suum ASU_12501 I 0.852
SPAL_0000490500 Strongyloides papillosus SPAL_0000490500 I 0.850
SVE_1951500 Strongyloides venezuelensis SVE_1951500 I 0.850
SMUV_0000708401 Syphacia muris SMUV_0000708401 I 0.848
HCOI01554200 Haemonchus contortus HCOI01554200 I 0.848
ACOC_0000700901 Angiostrongylus costaricensis ACOC_0000700901 I 0.848
CBN19235 Caenorhabditis brenneri CBN19235 I 0.848
EVEC_0000027301 Enterobius vermicularis EVEC_0000027301 I 0.848
ANCCEY_01961 Ancylostoma ceylanicum ANCCEY_01961 I 0.848
CJA13458 Caenorhabditis japonica CJA13458 I 0.848
nhr-1 Caenorhabditis elegans WBGene00003600 D 0.848
DICVIV_09815 Dictyocaulus viviparus DICVIV_09815 I 0.848
CRE03310 Caenorhabditis remanei CRE03310 I 0.848
HPBE_0000837301 Heligmosomoides bakeri HPBE_0000837301 I 0.848
CBG01866 Caenorhabditis briggsae CBG01866 I 0.848
nhr-10 Caenorhabditis elegans WBGene00003609 I 0.846
L898_g2764 Steinernema monticolum L898_g2764 I 0.845
L889_g29879 Steinernema feltiae L889_g29879 I 0.845
L596_g12321 Steinernema carpocapsae L596_g12321 I 0.845
L893_g3010 Steinernema glaseri L893_g3010 I 0.845
LOAG_00300 Loa loa LOAG_00300 I 0.843
Bm5319 Brugia malayi Bm5319 I 0.843
TCLT_0000399401 Thelazia callipaeda TCLT_0000399401 I 0.843
nOo.2.0.1.g01530 Onchocerca ochengi nOo.2.0.1.g01530 I 0.843
BTMF_0001388101 Brugia timori BTMF_0001388101 I 0.843
nDi.2.2.2.g02318 Dirofilaria immitis nDi.2.2.2.g02318 I 0.843
OFLC_0001450101 Onchocerca flexuosa OFLC_0001450101 I 0.843
SMUV_0001072301 Syphacia muris SMUV_0001072301 I 0.840
BXY_0360200 Bursaphelenchus xylophilus BXY_0360200 I 0.838
MhA1_Contig2491.frz3.gene4 Meloidogyne hapla MhA1_Contig2491.frz3.gene4 I 0.837
DME_0000693601 Dracunculus medinensis DME_0000693601 I 0.834
SSTP_0001081300 Strongyloides stercoralis SSTP_0001081300 I 0.834
WBGene00241993 Onchocerca volvulus WBGene00241993 I 0.834
L889_g7780 Steinernema feltiae L889_g7780 I 0.831
L898_g22454 Steinernema monticolum L898_g22454 I 0.831
L892_g8671 Steinernema scapterisci L892_g8671 I 0.831
L596_g12276 Steinernema carpocapsae L596_g12276 I 0.831
CRE25378 Caenorhabditis remanei CRE25378 I 0.831
CBN20518 Caenorhabditis brenneri CBN20518 I 0.829
CBG16594 Caenorhabditis briggsae CBG16594 I 0.829
nOo.2.0.1.g03859 Onchocerca ochengi nOo.2.0.1.g03859 I 0.827
WBGene00240560 Onchocerca volvulus WBGene00240560 I 0.827
nLs.2.1.2.g04051 Litomosoides sigmodontis nLs.2.1.2.g04051 I 0.821
LOAG_08636 Loa loa LOAG_08636 I 0.819
EEL_0000204901 Elaeophora elaphi EEL_0000204901 I 0.819
nAv.1.0.1.g09196 Acanthocheilonema viteae nAv.1.0.1.g09196 I 0.819
nDi.2.2.2.g09348 Dirofilaria immitis nDi.2.2.2.g09348 I 0.819
DME_0000747901 Dracunculus medinensis DME_0000747901 I 0.811
PTRK_0000194200 Parastrongyloides trichosuri PTRK_0000194200 I 0.807
TCLT_0000612301 Thelazia callipaeda TCLT_0000612301 I 0.806
ASU_13587 Ascaris suum ASU_13587 I 0.800
SMUV_0000475001 Syphacia muris SMUV_0000475001 I 0.795
SVE_0268000 Strongyloides venezuelensis SVE_0268000 I 0.794
SPAL_0000038800 Strongyloides papillosus SPAL_0000038800 I 0.794
RSKR_0001171300 Rhabditophanes kr3021 RSKR_0001171300 I 0.792
RSKR_0001067400 Rhabditophanes kr3021 RSKR_0001067400 I 0.789
CJA14829 Caenorhabditis japonica CJA14829 I 0.786
ASU_10584 Ascaris suum ASU_10584 I 0.786
L898_g8573 Steinernema monticolum L898_g8573 I 0.786
L893_g15276 Steinernema glaseri L893_g15276 I 0.786
L596_g19151 Steinernema carpocapsae L596_g19151 I 0.786
L889_g22901 Steinernema feltiae L889_g22901 I 0.786
L892_g5079 Steinernema scapterisci L892_g5079 I 0.786
augustus_masked-nMf.1.1.scaf15282-processed-gene-0.0 Meloidogyne floridensis augustus_masked-nMf.1.1.scaf15282-processed-gene-0.0 I 0.785
augustus_masked-nMf.1.1.scaf15936-processed-gene-0.0 Meloidogyne floridensis augustus_masked-nMf.1.1.scaf15936-processed-gene-0.0 I 0.785
MhA1_Contig320.frz3.gene45 Meloidogyne hapla MhA1_Contig320.frz3.gene45 I 0.785
EVEC_0000477801 Enterobius vermicularis EVEC_0000477801 I 0.783
ASU_02770 Ascaris suum ASU_02770 I 0.783
SMUV_0000657401 Syphacia muris SMUV_0000657401 I 0.783
ASIM_0001308601 Anisakis simplex ASIM_0001308601 I 0.782
CBG09380 Caenorhabditis briggsae CBG09380 I 0.777
PPA16374 Pristionchus pacificus PPA16374 I 0.775
SVE_1749000 Strongyloides venezuelensis SVE_1749000 I 0.774
SSTP_0000408200 Strongyloides stercoralis SSTP_0000408200 I 0.774
EFV54558 Trichinella spiralis EFV54558 I 0.773
D917_06779 Trichinella nativa D917_06779 I 0.773
SPAL_0000231300 Strongyloides papillosus SPAL_0000231300 I 0.772
TCNE_0001076801 Toxocara canis TCNE_0001076801 N 0.772
BXY_0988800 Bursaphelenchus xylophilus BXY_0988800 I 0.772
scaffold314-EXSNAP2012.19 Pristionchus exspectatus scaffold314-EXSNAP2012.19 I 0.772
BXY_1375200 Bursaphelenchus xylophilus BXY_1375200 I 0.771
Hba_12764 Heterorhabditis bacteriophora Hba_12764 N 0.771
scaffold107-EXSNAP2012.33 Pristionchus exspectatus scaffold107-EXSNAP2012.33 I 0.769
PPA22443 Pristionchus pacificus PPA22443 I 0.769
scaffold290-EXSNAP2012.30 Pristionchus exspectatus scaffold290-EXSNAP2012.30 I 0.767
PPA20196 Pristionchus pacificus PPA20196 I 0.767
CRE26981 Caenorhabditis remanei CRE26981 I 0.764
GPLIN_000694800 Globodera pallida GPLIN_000694800 N 0.758
L889_g22425 Steinernema feltiae L889_g22425 N 0.754
ANCDUO_17367 Ancylostoma duodenale ANCDUO_17367 I 0.753
ANCCAN_19046 Ancylostoma caninum ANCCAN_19046 I 0.753
NECAME_01070 Necator americanus NECAME_01070 I 0.753
DICVIV_13545 Dictyocaulus viviparus DICVIV_13545 I 0.753
HCOI00052900 Haemonchus contortus HCOI00052900 I 0.753
ACOC_0000744201 Angiostrongylus costaricensis ACOC_0000744201 I 0.753
ALUE_0001920701 Ascaris lumbricoides ALUE_0001920701 N 0.750
nhr-154 Caenorhabditis elegans WBGene00007547 D 0.750
ASU_02757 Ascaris suum ASU_02757 N 0.749
Minc02318 Meloidogyne incognita Minc02318 I 0.749
Minc05752 Meloidogyne incognita Minc05752 I 0.749
SPAL_0001084400 Strongyloides papillosus SPAL_0001084400 I 0.748
SSTP_0001035300 Strongyloides stercoralis SSTP_0001035300 I 0.748
SPAL_0001084500 Strongyloides papillosus SPAL_0001084500 I 0.748
PTRK_0001163100 Parastrongyloides trichosuri PTRK_0001163100 I 0.748
SVE_0956400 Strongyloides venezuelensis SVE_0956400 I 0.748
L892_g2422 Steinernema scapterisci L892_g2422 I 0.747
L596_g14199 Steinernema carpocapsae L596_g14199 I 0.747
nhr-101 Caenorhabditis elegans WBGene00003691 I 0.746