SIX6 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000184302 T209927_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SIX6
M00325_2.00		 Homo sapiens
NNNDATMB
VKATHNNN		 PBM
Barrera et al.(2016)
SIX6_H141N		 (Direct) (Direct)
SIX6
M00326_2.00		 Homo sapiens
NNDATMB
VKATHNN		 PBM
Barrera et al.(2016)
SIX6_REF		 (Direct) (Direct)
SIX6
M00327_2.00		 Homo sapiens
NHDAYMBNN
NNVKRTHDN		 PBM
Barrera et al.(2016)
SIX6_T165A		 (Direct) (Direct)
SIX6
M05357_2.00		 Homo sapiens
NNYGATASVB
VBSTATCRNN		 SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX		 (Direct) (Direct)
SIX6
M05358_2.00		 Homo sapiens
VBVYAYCRNN
NNYGRTRBVB		 SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Six6
M00169_2.00 		Mus musculus
NNAYMNN
NNKRTNN		 PBM
Badis et al.(2009)
Six6_2267 		0.867 1.000
Six6
M00412_2.00 		Mus musculus
NNNTGATAYCN
NGRTATCANNN		 PBM
Berger et al.(2008)
Six6_2267 		0.867 1.000
Six3
M00483_2.00 		Mus musculus
NNNAYMN
NKRTNNN		 PBM
Berger et al.(2008)
Six3_1732 		0.865 0.982
SIX3
M05159_2.00 		Homo sapiens
NNYGATABBN
NVVTATCRNN		 SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX 		0.865 0.982
SIX3
M10698_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX3_Q6 		0.865 0.982
SIX3
M05160_2.00 		Homo sapiens
NNYGATABVB
VBVTATCRNN		 SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX 		0.865 0.982
six3
M02102_2.00 		Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN		 PBM
Weirauch et al.(2014)
pTH5928 		0.865 0.947
Optix
M02124_2.00 		Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN		 PBM
Weirauch et al.(2014)
pTH5437 		0.865 0.930
Optix
M03850_2.00 		Drosophila melanogaster
TAATYTAATTA
TAATTARATTA		 SELEX
Nitta et al.(2015)
Optix_1 		0.865 0.930
Optix
M06526_2.00 		Drosophila melanogaster
TGATA
TATCA		 B1H
Mathelier et al.(2014)
MA0199.1 		0.865 0.930
Optix
M06327_2.00 		Drosophila melanogaster
HHVTGATA
TATCABDD		 B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360 		0.865 0.930
Optix
M06328_2.00 		Drosophila melanogaster
NNNTGATA
TATCANNN		 B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360 		0.865 0.930
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00325_2.00 Homeodomain 11 67
M00326_2.00 Homeodomain 11 67
M00327_2.00 Homeodomain 11 67

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000328596 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

296 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AABR07025074.1 Rattus norvegicus ENSRNOG00000032550 N
AAEL011380 Aedes aegypti AAEL011380 N
AALB006743 Anopheles albimanus AALB006743 N
AARA010318 Anopheles arabiensis AARA010318 N
AATE018776 Anopheles atroparvus AATE018776 N
AC135696.1 Rattus norvegicus ENSRNOG00000058908 N
ACEP16613 Atta cephalotes ACEP16613 N
ACOC_0000768601 Angiostrongylus costaricensis ACOC_0000768601 N
ACUA021022 Anopheles culicifacies ACUA021022 N
ACYPI007949 Acyrthosiphon pisum ACYPI007949 N
ADAC001494 Anopheles darlingi ADAC001494 N
ADIR011701 Anopheles dirus ADIR011701 N
AEPI002924 Anopheles epiroticus AEPI002924 N
AFAF003948 Anopheles farauti AFAF003948 N
AFUN010134 Anopheles funestus AFUN010134 N
AGAP000005 Anopheles gambiae AGAP000005 N
AMAM015540 Anopheles maculatus AMAM015540 N
AMEC021909 Anopheles melas AMEC021909 N
AMEM017336 Anopheles merus AMEM017336 N
AMIN005344 Anopheles minimus AMIN005344 N
ANCCAN_10156 Ancylostoma caninum ANCCAN_10156 N
AQUA004962 Anopheles quadriannulatus AQUA004962 N
ASIS000124 Anopheles sinensis ASIS000124 N
ASU_03902 Ascaris suum ASU_03902 N
augustus_masked-nMf.1.1.scaf01778-processed-gene-0.2 Meloidogyne floridensis augustus_masked-nMf.1.1.scaf01778-processed-gene-0.2 N
A_00070 Schistosoma haematobium A_00070 N
A_05510 Schistosoma haematobium A_05510 N
BAA06440 Xenopus laevis BAA06440 N
BGIBMGA001132 Bombyx mori BGIBMGA001132 N
BGLB010942 Biomphalaria glabrata BGLB010942 N
Bm4180 Brugia malayi Bm4180 N
BXY_1555400 Bursaphelenchus xylophilus BXY_1555400 N
CapteG158220 Capitella teleta CapteG158220 N
CBG17468 Caenorhabditis briggsae CBG17468 N
CBN17977 Caenorhabditis brenneri CBN17977 N
Cflo_05895--XP_001121384.1_APIME Camponotus floridanus Cflo_05895--XP_001121384.1_APIME N
CGI_10023724 Crassostrea gigas CGI_10023724 N
CJA09678 Caenorhabditis japonica CJA09678 N
CPIJ014043 Culex quinquefasciatus CPIJ014043 N
CpipJ_CPIJ014043 Culex pipiens CpipJ_CPIJ014043 N
CRE02943 Caenorhabditis remanei CRE02943 N
csin110255 Clonorchis sinensis csin110255 N
csin112095 Clonorchis sinensis csin112095 N
D915_00818 Fasciola hepatica D915_00818 N
D915_15256 Fasciola hepatica D915_15256 N
D917_01254 Trichinella nativa D917_01254 N
D917_08189 Trichinella nativa D917_08189 N
D918_07195 Trichuris suis D918_07195 N
DAPPUDRAFT_232871 Daphnia pulex DAPPUDRAFT_232871 N
DAPPUDRAFT_306496 Daphnia pulex DAPPUDRAFT_306496 N
DILT_0000548601 Diphyllobothrium latum DILT_0000548601 N
DILT_0001497901 Diphyllobothrium latum DILT_0001497901 N
DME_0001055201 Dracunculus medinensis DME_0001055201 N
Dsp1 Drosophila melanogaster FBgn0011764 N
ECANG7_02036 Echinococcus canadensis ECANG7_02036 N
ECANG7_05481 Echinococcus canadensis ECANG7_05481 N
EEL_0000068601 Elaeophora elaphi EEL_0000068601 N
EFV57410 Trichinella spiralis EFV57410 N
EmuJ_000768300 Echinococcus multilocularis EmuJ_000768300 N
EmuJ_001049000 Echinococcus multilocularis EmuJ_001049000 N
ENSAMXG00000014832 Astyanax mexicanus ENSAMXG00000014832 N
ENSCJAG00000008378 Callithrix jacchus ENSCJAG00000008378 N
ENSCJAG00000008384 Callithrix jacchus ENSCJAG00000008384 N
ENSCJAG00000022832 Callithrix jacchus ENSCJAG00000022832 N
ENSCPOG00000003985 Cavia porcellus ENSCPOG00000003985 N
ENSCSAVG00000000341 Ciona savignyi ENSCSAVG00000000341 N
ENSDNOG00000005537 Dasypus novemcinctus ENSDNOG00000005537 N
ENSECAG00000005186 Equus caballus ENSECAG00000005186 N
ENSFCAG00000028961 Felis catus ENSFCAG00000028961 N
ENSMICG00000016224 Microcebus murinus ENSMICG00000016224 N
ENSMMUG00000001275 Macaca mulatta ENSMMUG00000001275 N
ENSMODG00000009238 Monodelphis domestica ENSMODG00000009238 N
ENSOARG00000010383 Ovis aries ENSOARG00000010383 N
ENSOARG00000011611 Ovis aries ENSOARG00000011611 N
ENSOARG00000015382 Ovis aries ENSOARG00000015382 N
ENSOARG00000015955 Ovis aries ENSOARG00000015955 N
ENSOARG00000017078 Ovis aries ENSOARG00000017078 N
ENSOCUG00000004133 Oryctolagus cuniculus ENSOCUG00000004133 N
ENSOCUG00000021132 Oryctolagus cuniculus ENSOCUG00000021132 N
ENSOGAG00000028411 Otolemur garnettii ENSOGAG00000028411 N
ENSPANG00000005029 Papio anubis ENSPANG00000005029 N
ENSPANG00000007527 Papio anubis ENSPANG00000007527 N
ENSPANG00000011105 Papio anubis ENSPANG00000011105 N
ENSPFOG00000008464 Poecilia formosa ENSPFOG00000008464 N
ENSPPYG00000011668 Pongo abelii ENSPPYG00000011668 N
ENSSTOG00000000443 Ictidomys tridecemlineatus ENSSTOG00000000443 N
ENSSTOG00000012404 Ictidomys tridecemlineatus ENSSTOG00000012404 N
ENSTBEG00000009427 Tupaia belangeri ENSTBEG00000009427 N
EVEC_0000577301 Enterobius vermicularis EVEC_0000577301 N
fgenesh2_pm.scaffold_24000033 Branchiostoma floridae fgenesh2_pm.scaffold_24000033 N
GA11488 Drosophila pseudoobscura FBgn0071539 N
GD17278 Drosophila simulans FBgn0188840 N
GE17263 Drosophila yakuba FBgn0234741 N
genemark-nMf.1.1.scaf06964-processed-gene-0.3 Meloidogyne floridensis genemark-nMf.1.1.scaf06964-processed-gene-0.3 N
GF19115 Drosophila ananassae FBgn0096126 N
GG17955 Drosophila erecta FBgn0110175 N
GH12282 Drosophila grimshawi FBgn0119761 N
GI10980 Drosophila mojavensis FBgn0133743 N
GJ19445 Drosophila virilis FBgn0206588 N
GK25058 Drosophila willistoni FBgn0227017 N
Hba_13817 Heterorhabditis bacteriophora Hba_13817 N
HCOI00860100 Haemonchus contortus HCOI00860100 N
HDID_0000237901 Hymenolepis diminuta HDID_0000237901 N
HDID_0000408601 Hymenolepis diminuta HDID_0000408601 N
HelroG157878 Helobdella robusta HelroG157878 N
HMEL007340 Heliconius melpomene HMEL007340 N
hmg-1.2 Caenorhabditis elegans WBGene00001972 N
hmg1/2 Ciona intestinalis ENSCING00000004075 N
Hmg1l1 Rattus norvegicus ENSRNOG00000034130 N
Hmg1l1 Rattus norvegicus ENSRNOG00000051482 N
HMGB1 Microcebus murinus ENSMICG00000006213 N
hmgb1a Danio rerio ENSDARG00000099175 N
hmgb1a Takifugu rubripes ENSTRUG00000008452 N
HMGB2 Macaca mulatta ENSMMUG00000020008 N
Hmgb2 Rattus norvegicus ENSRNOG00000033321 N
HMGB2 Sus scrofa ENSSSCG00000009704 N
hmgb2.S Xenopus laevis XB-GENE-1000251 N
Hmgb2l1 Rattus norvegicus ENSRNOG00000013167 N
HmN_000466000 Hymenolepis microstoma HmN_000466000 N
HmN_000813000 Hymenolepis microstoma HmN_000813000 N
HNAJ_0000974401 Hymenolepis nana HNAJ_0000974401 N
HNAJ_0001249801 Hymenolepis nana HNAJ_0001249801 N
Hsal_13110--XP_001121384.1_APIME Harpegnathos saltator Hsal_13110--XP_001121384.1_APIME N
ISCW017350 Ixodes scapularis ISCW017350 N
L596_g22130 Steinernema carpocapsae L596_g22130 N
L889_g13533 Steinernema feltiae L889_g13533 N
L892_g17551 Steinernema scapterisci L892_g17551 N
L893_g5947 Steinernema glaseri L893_g5947 N
LCUP007363 Lucilia cuprina LCUP007363 N
LDEC006842 Leptinotarsa decemlineata LDEC006842 N
LOAG_04936 Loa loa LOAG_04936 N
LotgiG200052 Lottia gigantea LotgiG200052 N
MCOS_0000526101 Mesocestoides corti MCOS_0000526101 N
MCOS_0000726501 Mesocestoides corti MCOS_0000726501 N
MDOA008812 Musca domestica MDOA008812 N
Myotis_brandtii_Hmgb2_10018437 Myotis brandtii Myotis_brandtii_Hmgb2_10018437 N
nAv.1.0.1.g02101 Acanthocheilonema viteae nAv.1.0.1.g02101 N
NBR_0000911001 Nippostrongylus brasiliensis NBR_0000911001 N
nDi.2.2.2.g04979 Dirofilaria immitis nDi.2.2.2.g04979 N
NECAME_09126 Necator americanus NECAME_09126 N
nRc.2.0.1.g43473 Romanomermis culicivorax nRc.2.0.1.g43473 N
NV15664 Nasonia vitripennis NV15664 N
PEQ_0000150901 Parascaris equorum PEQ_0000150901 N
PHUM006290 Pediculus humanus PHUM006290 N
Ppa-hmg-1.2 Pristionchus pacificus PPA02361 N
PTRK_0000986200 Parastrongyloides trichosuri PTRK_0000986200 N
PXEA_0000637001 Protopolystoma xenopodis PXEA_0000637001 N
PXEA_0002175501 Protopolystoma xenopodis PXEA_0002175501 N
RGD1561694 Rattus norvegicus ENSRNOG00000029107 N
RSKR_0000605700 Rhabditophanes kr3021 RSKR_0000605700 N
Sakowv30042012m.g Saccoglossus kowalevskii Sakowv30042012m.g N
SBAD_0000405201 Soboliphyme baturini SBAD_0000405201 N
scaffold580-EXSNAP2012.5 Pristionchus exspectatus scaffold580-EXSNAP2012.5 N
SCUD_0000020101 Schistosoma curassoni SCUD_0000020101 N
SCUD_0000067701 Schistosoma curassoni SCUD_0000067701 N
SCUD_0001034301 Schistosoma curassoni SCUD_0001034301 N
SINV22586 Solenopsis invicta SINV22586 N
Sjc_0031360 Schistosoma japonicum Sjc_0031360 N
Sjc_0051340 Schistosoma japonicum Sjc_0051340 N
SMAR013695 Strigamia maritima SMAR013695 N
Smp_000980 Schistosoma mansoni Smp_000980 N
Smp_100090 Schistosoma mansoni Smp_100090 N
Smp_103530 Schistosoma mansoni Smp_103530 N
SMRZ_0000146101 Schistosoma margrebowiei SMRZ_0000146101 N
SMRZ_0000842001 Schistosoma margrebowiei SMRZ_0000842001 N
SMRZ_0001808901 Schistosoma margrebowiei SMRZ_0001808901 N
SMTD_0001017101 Schistosoma mattheei SMTD_0001017101 N
SMTD_0001194601 Schistosoma mattheei SMTD_0001194601 N
SMU15002907 Schmidtea mediterranea SMU15002907 N
SMU15016767 Schmidtea mediterranea SMU15016767 N
SMU15030256 Schmidtea mediterranea SMU15030256 N
SMU15030485 Schmidtea mediterranea SMU15030485 N
SMUV_0000232601 Syphacia muris SMUV_0000232601 N
SPAL_0001030300 Strongyloides papillosus SPAL_0001030300 N
SPU_005572 Strongylocentrotus purpuratus SPU_005572 N
SROB_0000153901 Schistosoma rodhaini SROB_0000153901 N
SROB_0000500401 Schistosoma rodhaini SROB_0000500401 N
SROB_0001061001 Schistosoma rodhaini SROB_0001061001 N
SSLN_0000493501 Schistocephalus solidus SSLN_0000493501 N
SSTP_0000371800 Strongyloides stercoralis SSTP_0000371800 N
SVE_0494300 Strongyloides venezuelensis SVE_0494300 N
T265_10726 Opisthorchis viverrini T265_10726 N
T265_12733 Opisthorchis viverrini T265_12733 N
T265_14643 Opisthorchis viverrini T265_14643 N
TCLT_0000879501 Thelazia callipaeda TCLT_0000879501 N
TCNE_0000567001 Toxocara canis TCNE_0000567001 N
TELCIR_07111 Teladorsagia circumcincta TELCIR_07111 N
tetur02g08260 Tetranychus urticae tetur02g08260 N
tetur02g08340 Tetranychus urticae tetur02g08340 N
TMUE_s0235000800 Trichuris muris TMUE_s0235000800 N
TRE_0000506801 Trichobilharzia regenti TRE_0000506801 N
TsM_000088100 Taenia solium TsM_000088100 N
TsM_000115400 Taenia solium TsM_000115400 N
TTAC_0000194001 Hydatigera taeniaeformis TTAC_0000194001 N
TTAC_0000225801 Hydatigera taeniaeformis TTAC_0000225801 N
TTRE_0000338301 Trichuris trichiura TTRE_0000338301 N
WBGene00245261 Onchocerca volvulus WBGene00245261 N
YQE_03203 Dendroctonus ponderosae YQE_03203 N