Pax4 (Mus musculus)
Homeodomain,Paired box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00292 (PAX) 		IPR001356
IPR001523 		ENSMUSG00000029706 T237409_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pax4
M00542_2.00		 Mus musculus
NNNATTAN
NTAATNNN		 PBM
Berger et al.(2008)
Pax4_3989		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PAX4
M00350_2.00 		Homo sapiens
NNNATTAN
NTAATNNN		 PBM
Barrera et al.(2016)
PAX4_REF 		0.882 0.882
PAX4
M00351_2.00 		Homo sapiens
NNNATTAN
NTAATNNN		 PBM
Barrera et al.(2016)
PAX4_REF_R3 		0.882 0.882
PAX4
M03295_2.00 		Homo sapiens
HKAATTAR
YTAATTMD		 SELEX
Jolma et al.(2013)
PAX4_1 		0.882 0.882
PAX4
M03296_2.00 		Homo sapiens
YKAATTAV
BTAATTMR		 SELEX
Jolma et al.(2013)
PAX4_2 		0.882 0.882
PAX4
M03883_2.00 		Homo sapiens
SGTCACGCWTSRNTG
CANYSAWGCGTGACS		 SELEX
Nitta et al.(2015)
PAX4_1 		0.882 0.882
PAX4
M03884_2.00 		Homo sapiens
NNAATTANYKAATDMV
BKHATTMRNTAATTNN		 SELEX
Nitta et al.(2015)
PAX4_2 		0.882 0.882
PAX4
M05430_2.00 		Homo sapiens
NAATTANNNNNNVNTAATTN
NAATTANBNNNNNNTAATTN		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_1 		0.882 0.882
PAX4
M05431_2.00 		Homo sapiens
NRYTWYACGCWTSRNYRNNYV
BRNNYRNYSAWGCGTRWARYN		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_2 		0.901 0.901
PAX4
M05432_2.00 		Homo sapiens
NTYACGCWYSRNYKMVYN
NRBKMRNYSRWGCGTRAN		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_3 		0.882 0.882
PAX4
M05433_2.00 		Homo sapiens
WHACGSTMATTDR
YHAATKASCGTDW		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_4 		0.882 0.882
PAX4
M10811_2.00 		Homo sapiens
NVNBSNNYVCGCHTSAMBNCN
NGNVKTSADGCGBRNNSVNBN		 Transfac
Matys et al.(2006)
V$PAX4_01 		0.882 0.882
PAX4
M10812_2.00 		Homo sapiens
NAHWAATTDVV
BBHAATTWDTN		 Transfac
Matys et al.(2006)
V$PAX4_02 		0.882 0.882
PAX4
M10813_2.00 		Homo sapiens
NDNNHYCACCCB
VGGGTGRDNNHN		 Transfac
Matys et al.(2006)
V$PAX4_03 		0.882 0.882
PAX4
M10814_2.00 		Homo sapiens
RRAAAWWRNNHHNVHHNVHVNNHHSAYHSB
VSDRTSDDNNBDBNDDBNDDNNYWWTTTYY		 Transfac
Matys et al.(2006)
V$PAX4_04 		0.882 0.882
PAX4
M10815_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX4_Q2 		0.882 0.882
PAX4
M05434_2.00 		Homo sapiens
NHATTANBTAATDN
NHATTAVNTAATDN		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_1 		0.901 0.901
PAX4
M05435_2.00 		Homo sapiens
VATTWYACGCWTSRNYDVNYN
NRNBHRNYSAWGCGTRWAATB		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_2 		0.882 0.882
PAX4
M05436_2.00 		Homo sapiens
HTYACGCWTSANYGMNYN
NRNKCRNTSAWGCGTRAD		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_3 		0.882 0.882
PAX4
M05437_2.00 		Homo sapiens
DHRYGCTAATTAN
NTAATTAGCRYDH		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_4 		0.882 0.882
PAX4
M00347_2.00 		Homo sapiens
NNNATND
HNATNNN		 PBM
Barrera et al.(2016)
PAX4_R183C 		0.876 0.876
PAX4
M00348_2.00 		Homo sapiens
NNDATTAN
NTAATHNN		 PBM
Barrera et al.(2016)
PAX4_R192H 		0.876 0.876
PAX4
M00349_2.00 		Homo sapiens
NNNATTANN
NNTAATNNN		 PBM
Barrera et al.(2016)
PAX4_R192S 		0.876 0.876
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00542_2.00 Paired box 4 128
M00542_2.00 Homeodomain 170 226

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000031718 Paired box 5 129
ENSMUSP00000031718 Homeodomain 171 227
ENSMUSP00000126000 Paired box 5 129
ENSMUSP00000126000 Homeodomain 171 227
ENSMUSP00000131301 Paired box 5 129
ENSMUSP00000131301 Homeodomain 171 227
ENSMUSP00000134470 Paired box 5 129
ENSMUSP00000134470 Homeodomain 141 185

Links

Other Homeodomain,Paired box family TFs
Other Mus musculus TFs

41 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Pax4 Rattus norvegicus ENSRNOG00000008020 I 0.978
PAX4 Microcebus murinus ENSMICG00000000095 I 0.951
ENSBTAP00000042667-D1 Bos grunniens ENSBTAP00000042667-D1 I 0.945
ENSPPYG00000017971 Pongo abelii ENSPPYG00000017971 I 0.940
PAX4 Equus caballus ENSECAG00000008343 I 0.940
ENSSTOG00000002127 Ictidomys tridecemlineatus ENSSTOG00000002127 I 0.940
PAX4 Bos taurus ENSBTAG00000000410 I 0.940
Myotis_brandtii_Pax4_10010526 Myotis brandtii Myotis_brandtii_Pax4_10010526 I 0.940
PAX4 Canis familiaris ENSCAFG00000001719 I 0.934
ENSP00000368014 Macaca fascicularis ENSP00000368014 I 0.934
PAX4 Macaca mulatta ENSMMUG00000015429 I 0.934
ENSAMEG00000004648 Ailuropoda melanoleuca ENSAMEG00000004648 I 0.934
PAX4 Procavia capensis ENSPCAG00000016257 I 0.934
PAX4 Callithrix jacchus ENSCJAG00000017652 I 0.934
ENSCSAG00000010195 Chlorocebus sabaeus ENSCSAG00000010195 I 0.933
PAX4 Oryctolagus cuniculus ENSOCUG00000001612 I 0.929
ENSOARG00000001951 Ovis aries ENSOARG00000001951 I 0.929
PAX4 Felis catus ENSFCAG00000005485 I 0.929
PAX4 Otolemur garnettii ENSOGAG00000013348 I 0.929
ENSMPUG00000006575 Mustela putorius furo ENSMPUG00000006575 I 0.929
PAX4 Loxodonta africana ENSLAFG00000005297 I 0.924
PAX4 Sus scrofa ENSSSCG00000016591 I 0.923
PAX4 Pteropus vampyrus ENSPVAG00000013944 I 0.923
ENSNLEG00000012257 Nomascus leucogenys ENSNLEG00000012257 I 0.923
Pax4 Dipodomys ordii ENSDORG00000000332 I 0.923
PAX4 Erinaceus europaeus ENSEEUG00000009616 I 0.923
PAX4 Gorilla gorilla ENSGGOG00000002555 I 0.923
PAX4 Cavia porcellus ENSCPOG00000006244 I 0.923
PAX4 Homo sapiens ENSG00000106331 D 0.921
PAX4 Pan troglodytes ENSPTRG00000019653 I 0.918
PAX4 Tursiops truncatus ENSTTRG00000006056 I 0.911
PAX4 Choloepus hoffmanni ENSCHOG00000009265 I 0.895
PAX4 Sorex araneus ENSSARG00000004842 I 0.889
PAX4 Ochotona princeps ENSOPRG00000013381 I 0.863
ENSSHAG00000015143 Sarcophilus harrisii ENSSHAG00000015143 I 0.835
ENSDNOG00000030639 Dasypus novemcinctus ENSDNOG00000030639 I 0.808
PAX4 Myotis lucifugus ENSMLUG00000030302 I 0.797
PAX4 Ornithorhynchus anatinus ENSOANG00000000819 I 0.794
Afo_R008534 Aptenodytes forsteri Afo_R008534 I 0.753
Alligator_sinensis_CCG000926.1 Alligator sinensis Alligator_sinensis_CCG000926.1 I 0.717