PAX4 (Homo sapiens)
Homeodomain,Paired box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00292 (PAX) 		IPR001356
IPR001523 		ENSG00000106331 T237342_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PAX4
M00347_2.00		 Homo sapiens
NNNATND
HNATNNN		 PBM
Barrera et al.(2016)
PAX4_R183C		 (Direct) (Direct)
PAX4
M00348_2.00		 Homo sapiens
NNDATTAN
NTAATHNN		 PBM
Barrera et al.(2016)
PAX4_R192H		 (Direct) (Direct)
PAX4
M00349_2.00		 Homo sapiens
NNNATTANN
NNTAATNNN		 PBM
Barrera et al.(2016)
PAX4_R192S		 (Direct) (Direct)
PAX4
M00350_2.00		 Homo sapiens
NNNATTAN
NTAATNNN		 PBM
Barrera et al.(2016)
PAX4_REF		 (Direct) (Direct)
PAX4
M00351_2.00		 Homo sapiens
NNNATTAN
NTAATNNN		 PBM
Barrera et al.(2016)
PAX4_REF_R3		 (Direct) (Direct)
PAX4
M03295_2.00		 Homo sapiens
HKAATTAR
YTAATTMD		 SELEX
Jolma et al.(2013)
PAX4_1		 (Direct) (Direct)
PAX4
M03296_2.00		 Homo sapiens
YKAATTAV
BTAATTMR		 SELEX
Jolma et al.(2013)
PAX4_2		 (Direct) (Direct)
PAX4
M03883_2.00		 Homo sapiens
SGTCACGCWTSRNTG
CANYSAWGCGTGACS		 SELEX
Nitta et al.(2015)
PAX4_1		 (Direct) (Direct)
PAX4
M03884_2.00		 Homo sapiens
NNAATTANYKAATDMV
BKHATTMRNTAATTNN		 SELEX
Nitta et al.(2015)
PAX4_2		 (Direct) (Direct)
PAX4
M05430_2.00		 Homo sapiens
NAATTANNNNNNVNTAATTN
NAATTANBNNNNNNTAATTN		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_1		 (Direct) (Direct)
PAX4
M05431_2.00		 Homo sapiens
NRYTWYACGCWTSRNYRNNYV
BRNNYRNYSAWGCGTRWARYN		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_2		 (Direct) (Direct)
PAX4
M05432_2.00		 Homo sapiens
NTYACGCWYSRNYKMVYN
NRBKMRNYSRWGCGTRAN		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_3		 (Direct) (Direct)
PAX4
M05433_2.00		 Homo sapiens
WHACGSTMATTDR
YHAATKASCGTDW		 SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_4		 (Direct) (Direct)
PAX4
M05434_2.00		 Homo sapiens
NHATTANBTAATDN
NHATTAVNTAATDN		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
PAX4
M05435_2.00		 Homo sapiens
VATTWYACGCWTSRNYDVNYN
NRNBHRNYSAWGCGTRWAATB		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
PAX4
M05436_2.00		 Homo sapiens
HTYACGCWTSANYGMNYN
NRNKCRNTSAWGCGTRAD		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_3		 (Direct) (Direct)
PAX4
M05437_2.00		 Homo sapiens
DHRYGCTAATTAN
NTAATTAGCRYDH		 SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_4		 (Direct) (Direct)
PAX4
M10811_2.00		 Homo sapiens
NVNBSNNYVCGCHTSAMBNCN
NGNVKTSADGCGBRNNSVNBN		 Transfac
Matys et al.(2006)
V$PAX4_01		 (Direct) (Direct)
PAX4
M10812_2.00		 Homo sapiens
NAHWAATTDVV
BBHAATTWDTN		 Transfac
Matys et al.(2006)
V$PAX4_02		 (Direct) (Direct)
PAX4
M10813_2.00		 Homo sapiens
NDNNHYCACCCB
VGGGTGRDNNHN		 Transfac
Matys et al.(2006)
V$PAX4_03		 (Direct) (Direct)
PAX4
M10814_2.00		 Homo sapiens
RRAAAWWRNNHHNVHHNVHVNNHHSAYHSB
VSDRTSDDNNBDBNDDBNDDNNYWWTTTYY		 Transfac
Matys et al.(2006)
V$PAX4_04		 (Direct) (Direct)
PAX4
M10815_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX4_Q2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pax4
M00542_2.00 		Mus musculus
NNNATTAN
NTAATNNN		 PBM
Berger et al.(2008)
Pax4_3989 		0.836 0.836
PAX6
M00342_2.00 		Homo sapiens
NNNRCDMATTANNN
NNNTAATKHGYNNN		 PBM
Barrera et al.(2016)
PAX6_REF 		0.702 0.702
Pax6
M00540_2.00 		Mus musculus
CBAATTAA
TTAATTVG		 PBM
Berger et al.(2008)
Pax6_3838 		0.702 0.702
PAX6
M03291_2.00 		Homo sapiens
DTWYACGCWTGANTGMDYH
DRHKCANTCAWGCGTRWAH		 SELEX
Jolma et al.(2013)
PAX6_1 		0.702 0.702
PAX6
M05412_2.00 		Homo sapiens
NYACGCHYSRNYRMNYN
NRNKYRNYSRDGCGTRN		 SELEX
Yin et al.(2017)
PAX6_eDBD_HT-SELEX 		0.702 0.702
PAX6
M05414_2.00 		Homo sapiens
NYRCGCNYSRNYRVNYN
NRNBYRNYSRNGCGYRN		 SELEX
Yin et al.(2017)
PAX6_FL_HT-SELEX 		0.702 0.702
PAX6
M02689_2.00 		Homo sapiens
TTYACGCWTSANTK
MANTSAWGCGTRAA		 SELEX
Mathelier et al.(2014)
MA0069.1 		0.702 0.702
PAX6
M09216_2.00 		Homo sapiens
TYMYRCWTSRNT
ANYSAWGYRKRA		 Misc
Kulakovskiy et al.(2013)
PAX6_HUMAN.H11MO.0.C 		0.702 0.702
Pax6
M09217_2.00 		Mus musculus
TYMYRCWTSRNT
ANYSAWGYRKRA		 Misc
Kulakovskiy et al.(2013)
PAX6_MOUSE.H11MO.0.C 		0.702 0.702
PAX6
M10806_2.00 		Homo sapiens
NHNNTTYACGCWTSANTKVHH
DDBMANTSAWGCGTRAANNDN		 Transfac
Matys et al.(2006)
V$PAX6_01 		0.702 0.702
PAX6
M10807_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX6_Q2 		0.702 0.702
PAX6
M00340_2.00 		Homo sapiens
NNNNNRN
NYNNNNN		 PBM
Barrera et al.(2016)
PAX6_R242T 		0.702 0.702
PAX6
M05413_2.00 		Homo sapiens
DYRCGCWTSRNYRMNYN
NRNKYRNYSAWGCGYRH		 SELEX
Yin et al.(2017)
PAX6_eDBD_Methyl-HT-SELEX 		0.702 0.702
PAX6
M05415_2.00 		Homo sapiens
NYACGCHYSRNYRMHYN
NRDKYRNYSRDGCGTRN		 SELEX
Yin et al.(2017)
PAX6_FL_Methyl-HT-SELEX 		0.702 0.702
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00347_2.00 Paired box 1 121
M00347_2.00 Homeodomain 163 219
M00348_2.00 Paired box 1 121
M00348_2.00 Homeodomain 163 219
M00349_2.00 Paired box 1 121
M00349_2.00 Homeodomain 163 219
M00350_2.00 Paired box 1 121
M00350_2.00 Homeodomain 163 219
M00351_2.00 Paired box 1 121
M00351_2.00 Homeodomain 163 219

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000339906 Paired box 1 121
ENSP00000339906 Homeodomain 163 219
ENSP00000344297 Paired box 5 129
ENSP00000344297 Homeodomain 171 227
ENSP00000368014 Paired box 1 121
ENSP00000368014 Homeodomain 163 219
ENSP00000451923 Paired box 18 119
ENSP00000451923 Homeodomain 161 217
ENSP00000473846 Paired box 18 119
ENSP00000473846 Homeodomain 161 217
ENSP00000477877 Paired box 18 119
ENSP00000477877 Homeodomain 161 217

Links

Other Homeodomain,Paired box family TFs
Other Homo sapiens TFs

86 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
PAX4 Pan troglodytes ENSPTRG00000019653 I 1.000
PAX4 Gorilla gorilla ENSGGOG00000002555 I 0.995
ENSCSAG00000010195 Chlorocebus sabaeus ENSCSAG00000010195 I 0.989
PAX4 Callithrix jacchus ENSCJAG00000017652 I 0.984
PAX4 Macaca mulatta ENSMMUG00000015429 I 0.984
ENSNLEG00000012257 Nomascus leucogenys ENSNLEG00000012257 I 0.984
ENSP00000368014 Macaca fascicularis ENSP00000368014 I 0.984
ENSPPYG00000017971 Pongo abelii ENSPPYG00000017971 I 0.978
PAX4 Loxodonta africana ENSLAFG00000005297 I 0.977
PAX4 Canis familiaris ENSCAFG00000001719 I 0.973
PAX4 Microcebus murinus ENSMICG00000000095 I 0.967
PAX4 Sus scrofa ENSSSCG00000016591 I 0.967
ENSOARG00000001951 Ovis aries ENSOARG00000001951 I 0.967
ENSAMEG00000004648 Ailuropoda melanoleuca ENSAMEG00000004648 I 0.967
Myotis_brandtii_Pax4_10010526 Myotis brandtii Myotis_brandtii_Pax4_10010526 I 0.962
PAX4 Procavia capensis ENSPCAG00000016257 I 0.962
PAX4 Equus caballus ENSECAG00000008343 I 0.962
PAX4 Felis catus ENSFCAG00000005485 I 0.961
PAX4 Tursiops truncatus ENSTTRG00000006056 I 0.956
PAX4 Pteropus vampyrus ENSPVAG00000013944 I 0.956
PAX4 Oryctolagus cuniculus ENSOCUG00000001612 I 0.956
PAX4 Otolemur garnettii ENSOGAG00000013348 I 0.956
ENSBTAP00000042667-D1 Bos grunniens ENSBTAP00000042667-D1 I 0.956
PAX4 Bos taurus ENSBTAG00000000410 I 0.956
ENSMPUG00000006575 Mustela putorius furo ENSMPUG00000006575 I 0.956
PAX4 Ochotona princeps ENSOPRG00000013381 I 0.953
ENSDNOG00000030639 Dasypus novemcinctus ENSDNOG00000030639 I 0.951
PAX4 Myotis lucifugus ENSMLUG00000030302 I 0.949
PAX4 Vicugna pacos ENSVPAG00000008301 I 0.948
PAX4 Erinaceus europaeus ENSEEUG00000009616 I 0.945
ENSSTOG00000002127 Ictidomys tridecemlineatus ENSSTOG00000002127 I 0.945
PAX4 Cavia porcellus ENSCPOG00000006244 I 0.940
PAX4 Choloepus hoffmanni ENSCHOG00000009265 I 0.932
Pax4 Rattus norvegicus ENSRNOG00000008020 I 0.929
Pax4 Mus musculus ENSMUSG00000029706 D 0.921
Pax4 Dipodomys ordii ENSDORG00000000332 I 0.912
PAX4 Sorex araneus ENSSARG00000004842 I 0.906
ENSSHAG00000015143 Sarcophilus harrisii ENSSHAG00000015143 I 0.852
PAX4 Ornithorhynchus anatinus ENSOANG00000000819 I 0.806
Afo_R008534 Aptenodytes forsteri Afo_R008534 I 0.753
Alligator_sinensis_CCG000926.1 Alligator sinensis Alligator_sinensis_CCG000926.1 I 0.732
ENSONIG00000004074 Oreochromis niloticus ENSONIG00000004074 I 0.708
ENSXMAG00000016421 Xiphophorus maculatus ENSXMAG00000016421 I 0.708
ENSONIG00000005541 Oreochromis niloticus ENSONIG00000005541 I 0.708
pax6b Gasterosteus aculeatus ENSGACG00000016030 I 0.708
ENSPFOG00000016987 Poecilia formosa ENSPFOG00000016987 I 0.708
ENSXMAG00000014260 Xiphophorus maculatus ENSXMAG00000014260 I 0.708
pax6b Oryzias latipes ENSORLG00000009913 I 0.708
ENSSHAG00000016310 Sarcophilus harrisii ENSSHAG00000016310 I 0.702
Pax6 Rattus norvegicus ENSRNOG00000004410 I 0.702
PAX6 Sus scrofa ENSSSCG00000013320 I 0.702
pax6b Tetraodon nigroviridis ENSTNIG00000013804 I 0.702
Pvit_09512 Pogona vitticeps Pvit_09512 I 0.702
pax6b Takifugu rubripes ENSTRUG00000006935 I 0.702
PAX6 Tupaia belangeri ENSTBEG00000004748 I 0.702
ENSSTOG00000003211 Ictidomys tridecemlineatus ENSSTOG00000003211 I 0.702
Sakowv30026828m.g Saccoglossus kowalevskii Sakowv30026828m.g I 0.702
Alligator_sinensis_CCG012954.1 Alligator sinensis Alligator_sinensis_CCG012954.1 I 0.702
pax6 Xenopus tropicalis XB-GENE-484088 I 0.702
PAX6 Ochotona princeps ENSOPRG00000001678 I 0.702
ENSLACG00000015337 Latimeria chalumnae ENSLACG00000015337 I 0.702
ENSGMOG00000012304 Gadus morhua ENSGMOG00000012304 I 0.702
pax6b Danio rerio ENSDARG00000045936 I 0.702
ENSLOCG00000004578 Lepisosteus oculatus ENSLOCG00000004578 I 0.702
ENSCSAG00000005253 Chlorocebus sabaeus ENSCSAG00000005253 I 0.702
PAX6 Gorilla gorilla ENSGGOG00000010246 I 0.702
pax6a Danio rerio ENSDARG00000103379 I 0.702
PAX6 Homo sapiens ENSG00000007372 D 0.702
PAX6 Dasypus novemcinctus ENSDNOG00000000761 I 0.702
ENSGACG00000002490 Gasterosteus aculeatus ENSGACG00000002490 I 0.702
PAX6 Gallus gallus ENSGALG00000012123 I 0.702
PAX6 Microcebus murinus ENSMICG00000004089 I 0.702
PAX6 Myotis lucifugus ENSMLUG00000006517 I 0.702
ENSORLG00000000847 Oryzias latipes ENSORLG00000000847 I 0.702
PAX6 Otolemur garnettii ENSOGAG00000007857 I 0.702
ENSPANG00000005448 Papio anubis ENSPANG00000005448 I 0.702
PAX6 Procavia capensis ENSPCAG00000005165 I 0.702
ENSPSIG00000012748 Pelodiscus sinensis ENSPSIG00000012748 I 0.702
ENSOARG00000016191 Ovis aries ENSOARG00000016191 I 0.702
PAX6 Anolis carolinensis ENSACAG00000002252 I 0.702
PAX6 Macaca mulatta ENSMMUG00000016810 I 0.702
ENSMPUG00000011295 Mustela putorius furo ENSMPUG00000011295 I 0.702
Pax6 Mus musculus ENSMUSG00000027168 D 0.702
PAX6 Callithrix jacchus ENSCJAG00000005942 I 0.702
PAX6 Bos taurus ENSBTAG00000004561 I 0.702