SMAD4 (Danio rerio)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSDARG00000012649 T324554_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Smad4
M05889_2.00 		Mus musculus
KCYAGACR
YGTCTRGM		 SMiLE-seq
Isakova et al.(2017)
Smad4 		0.971 0.971
SMAD4
M09377_2.00 		Homo sapiens
DRGTGNSAGACWN
NWGTCTSNCACYH		 Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B 		0.971 0.971
Smad4
M09382_2.00 		Mus musculus
DGWGNBAGVCWN
NWGBCTVNCWCH		 Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A 		0.971 0.971
SMAD4
M09634_2.00 		Homo sapiens
NNNYGTCTGS
SCAGACRNNN		 Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422 		0.971 0.971
SMAD4
M11275_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q4 		0.971 0.971
SMAD4
M11276_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q6_01 		0.971 0.971
SMAD4
M11277_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q6 		0.971 0.971
Med
M06447_2.00 		Drosophila melanogaster
KCGBCDKKSHVT
ABDSMMHGVCGM		 B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655 		0.951 0.951
Med
M09693_2.00 		Drosophila melanogaster
YYBYVYCTGYY
RRCAGRBRVRR		 Misc
Kulakovskiy et al.(2009)
Med 		0.951 0.951
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000048200 SMAD 33 134
ENSDARP00000099850 SMAD 33 134

Links

Other SMAD family TFs
Other Danio rerio TFs

220 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
SMAD4 Homo sapiens ENSG00000141646 D 0.982
Smad4 Mus musculus ENSMUSG00000024515 D 0.971
Med Drosophila melanogaster FBgn0011655 D 0.951
CpipJ_CPIJ002563 Culex pipiens CpipJ_CPIJ002563 I 0.971
WUBG_02880 Wuchereria bancrofti WUBG_02880 I 0.784
AAEL013896 Aedes aegypti AAEL013896 I 0.961
ACEP19585 Atta cephalotes ACEP19585 I 0.843
ACYPI000365 Acyrthosiphon pisum ACYPI000365 I 0.922
ACYPI003759 Acyrthosiphon pisum ACYPI003759 I 0.873
ACYPI005550 Acyrthosiphon pisum ACYPI005550 I 0.843
ACYPI008450 Acyrthosiphon pisum ACYPI008450 I 0.863
ADAC007516 Anopheles darlingi ADAC007516 I 0.941
AGAP002902 Anopheles gambiae AGAP002902 I 0.961
Aqu1.215833 Amphimedon queenslandica Aqu1.215833 I 0.833
Aqu1.215834 Amphimedon queenslandica Aqu1.215834 I 0.833
Aqu1.229767 Amphimedon queenslandica Aqu1.229767 I 0.716
BGIBMGA010110 Bombyx mori BGIBMGA010110 I 0.961
Bm3575 Brugia malayi Bm3575 I 0.794
CapteG179368 Capitella teleta CapteG179368 I 0.951
CBN31444 Caenorhabditis brenneri CBN31444 I 0.703
CGI_10000594 Crassostrea gigas CGI_10000594 I 0.804
CGI_10018464 Crassostrea gigas CGI_10018464 I 0.875
CPIJ002563 Culex quinquefasciatus CPIJ002563 I 0.971
DAPPUDRAFT_304115 Daphnia pulex DAPPUDRAFT_304115 I 0.961
EFV62078 Trichinella spiralis EFV62078 I 0.824
SMAD4 Anolis carolinensis ENSACAG00000010186 I 0.971
ENSAMEG00000002899 Ailuropoda melanoleuca ENSAMEG00000002899 I 0.971
ENSAMXG00000017275 Astyanax mexicanus ENSAMXG00000017275 I 0.951
ENSAMXG00000018339 Astyanax mexicanus ENSAMXG00000018339 I 0.951
ENSAMXG00000019219 Astyanax mexicanus ENSAMXG00000019219 I 0.980
ENSAPLG00000003924 Anas platyrhynchos ENSAPLG00000003924 I 0.971
SMAD4 Bos taurus ENSBTAG00000006919 I 0.971
SMAD4 Canis familiaris ENSCAFG00000000164 I 0.971
SMAD4 Choloepus hoffmanni ENSCHOG00000000860 I 0.971
smad4 Ciona intestinalis ENSCING00000005559 I 0.912
SMAD4 Callithrix jacchus ENSCJAG00000001910 I 0.971
SMAD4 Cavia porcellus ENSCPOG00000006470 I 0.971
ENSCSAG00000018094 Chlorocebus sabaeus ENSCSAG00000018094 I 0.971
ENSCSAVG00000006480 Ciona savignyi ENSCSAVG00000006480 I 0.912
si:dkey-222b8.1 Danio rerio ENSDARG00000045094 I 0.951
si:dkey-239n17.4 Danio rerio ENSDARG00000070428 I 0.941
smad4a Danio rerio ENSDARG00000075226 I 0.980
SMAD4 Dasypus novemcinctus ENSDNOG00000005063 I 0.971
Smad4 Dipodomys ordii ENSDORG00000009089 I 0.970
SMAD4 Equus caballus ENSECAG00000017857 I 0.971
SMAD4 Echinops telfairi ENSETEG00000007750 I 0.971
SMAD4 Felis catus ENSFCAG00000005257 I 0.971
si:dkey-222b8.1 Gasterosteus aculeatus ENSGACG00000000538 I 0.951
ENSGACG00000003171 Gasterosteus aculeatus ENSGACG00000003171 I 0.892
smad4a Gasterosteus aculeatus ENSGACG00000007495 I 0.990
ENSGACG00000016858 Gasterosteus aculeatus ENSGACG00000016858 I 0.971
SMAD4 Gorilla gorilla ENSGGOG00000013662 I 0.971
ENSGMOG00000000297 Gadus morhua ENSGMOG00000000297 I 0.941
ENSGMOG00000005844 Gadus morhua ENSGMOG00000005844 I 0.990
ENSGMOG00000013964 Gadus morhua ENSGMOG00000013964 I 0.961
ENSLACG00000007810 Latimeria chalumnae ENSLACG00000007810 I 0.951
SMAD4 Loxodonta africana ENSLAFG00000012595 I 0.971
ENSLOCG00000012872 Lepisosteus oculatus ENSLOCG00000012872 I 0.775
ENSMEUG00000001823 Macropus eugenii ENSMEUG00000001823 I 0.951
SMAD4 Microcebus murinus ENSMICG00000017525 I 0.979
SMAD4 Myotis lucifugus ENSMLUG00000013944 I 0.971
SMAD4 Macaca mulatta ENSMMUG00000018334 I 0.971
SMAD4 Monodelphis domestica ENSMODG00000010995 I 0.971
ENSMPUG00000008776 Mustela putorius furo ENSMPUG00000008776 I 0.971
ENSNLEG00000011859 Nomascus leucogenys ENSNLEG00000011859 I 0.971
SMAD4 Ornithorhynchus anatinus ENSOANG00000008117 I 0.971
ENSOANG00000030959 Ornithorhynchus anatinus ENSOANG00000030959 I 0.971
ENSOARG00000004662 Ovis aries ENSOARG00000004662 I 0.971
SMAD4 Oryctolagus cuniculus ENSOCUG00000003929 I 0.971
SMAD4 Otolemur garnettii ENSOGAG00000012081 I 0.971
ENSONIG00000001557 Oreochromis niloticus ENSONIG00000001557 I 0.931
ENSONIG00000010360 Oreochromis niloticus ENSONIG00000010360 I 0.931
ENSONIG00000014036 Oreochromis niloticus ENSONIG00000014036 I 0.971
ENSONIG00000015035 Oreochromis niloticus ENSONIG00000015035 I 0.980
SMAD4 Ochotona princeps ENSOPRG00000013601 I 0.971
smad4a Oryzias latipes ENSORLG00000005020 I 0.980
SMAD4 Oryzias latipes ENSORLG00000007703 I 0.961
ENSPANG00000024703 Papio anubis ENSPANG00000024703 I 0.971
ENSPFOG00000018987 Poecilia formosa ENSPFOG00000018987 I 0.980
ENSPFOG00000019807 Poecilia formosa ENSPFOG00000019807 I 0.961
ENSPFOG00000019867 Poecilia formosa ENSPFOG00000019867 I 0.892
ENSPMAG00000008404 Petromyzon marinus ENSPMAG00000008404 I 0.941
ENSPMAG00000009414 Petromyzon marinus ENSPMAG00000009414 I 0.912
ENSPPYG00000009165 Pongo abelii ENSPPYG00000009165 I 0.971
ENSPSIG00000014614 Pelodiscus sinensis ENSPSIG00000014614 I 0.971
SMAD4 Pan troglodytes ENSPTRG00000010028 I 0.971
SMAD4 Pteropus vampyrus ENSPVAG00000004261 I 0.979
Smad4 Rattus norvegicus ENSRNOG00000051965 I 0.971
ENSSHAG00000010344 Sarcophilus harrisii ENSSHAG00000010344 I 0.971
SMAD4 Sus scrofa ENSSSCG00000004524 I 0.971
ENSSTOG00000028580 Ictidomys tridecemlineatus ENSSTOG00000028580 I 0.971
SMAD4 Tupaia belangeri ENSTBEG00000014105 I 0.971
gb:cr929477 Tetraodon nigroviridis ENSTNIG00000003193 I 0.971
si:dkey-222b8.1 Tetraodon nigroviridis ENSTNIG00000005007 I 0.892
SMAD4 Tetraodon nigroviridis ENSTNIG00000009050 I 0.961
si:dkey-222b8.1 Takifugu rubripes ENSTRUG00000004163 I 0.951
gb:cr929477 Takifugu rubripes ENSTRUG00000011769 I 0.971
SMAD4 Takifugu rubripes ENSTRUG00000014045 I 0.961
ENSTSYG00000009792 Tarsius syrichta ENSTSYG00000009792 I 0.971
SMAD4 Vicugna pacos ENSVPAG00000006757 I 0.971
ENSXMAG00000005051 Xiphophorus maculatus ENSXMAG00000005051 I 0.961
ENSXMAG00000015245 Xiphophorus maculatus ENSXMAG00000015245 I 0.980
GA14643 Drosophila pseudoobscura FBgn0074670 I 0.951
GF22974 Drosophila ananassae FBgn0099968 I 0.951
GG11819 Drosophila erecta FBgn0104114 I 0.951
GH18642 Drosophila grimshawi FBgn0126109 I 0.951
GI23400 Drosophila mojavensis FBgn0146126 I 0.951
GL23637 Drosophila persimilis FBgn0161227 I 0.951
GM16436 Drosophila sechellia FBgn0171351 I 0.951
GJ23092 Drosophila virilis FBgn0210194 I 0.951
GK11724 Drosophila willistoni FBgn0213735 I 0.951
GE10952 Drosophila yakuba FBgn0228782 I 0.951
GB50071 Apis mellifera GB50071 I 0.971
HelroG76435 Helobdella robusta HelroG76435 I 0.804
HelroG88197 Helobdella robusta HelroG88197 I 0.873
HMEL002203 Heliconius melpomene HMEL002203 I 0.961
ISCW018468 Ixodes scapularis ISCW018468 I 0.951
KGM_12572 Danaus plexippus KGM_12572 I 0.961
L798_13939 Zootermopsis nevadensis L798_13939 I 0.961
LOAG_08923 Loa loa LOAG_08923 I 0.775
LotgiG131078 Lottia gigantea LotgiG131078 I 0.922
MCINX014520 Melitaea cinxia MCINX014520 I 0.961
ML02191a Mnemiopsis leidyi ML02191a I 0.843
NEMVEDRAFT_v1g18576 Nematostella vectensis NEMVEDRAFT_v1g18576 I 0.755
NEMVEDRAFT_v1g248037 Nematostella vectensis NEMVEDRAFT_v1g248037 I 0.922
NV12984 Nasonia vitripennis NV12984 I 0.971
PHUM002670 Pediculus humanus PHUM002670 I 0.961
RPRC010188 Rhodnius prolixus RPRC010188 I 0.941
SINV15516 Solenopsis invicta SINV15516 I 0.971
SMAR013850 Strigamia maritima SMAR013850 I 0.961
Smp_033950 Schistosoma mansoni Smp_033950 I 0.725
SPU_004287 Strongylocentrotus purpuratus SPU_004287 I 0.912
SPU_017971 Strongylocentrotus purpuratus SPU_017971 I 0.855
TC010848 Tribolium castaneum TC010848 I 0.951
tetur10g00380 Tetranychus urticae tetur10g00380 I 0.756
tetur10g00400 Tetranychus urticae tetur10g00400 I 0.882
TriadG30731 Trichoplax adhaerens TriadG30731 I 0.804
WBGene00241622 Onchocerca volvulus WBGene00241622 I 0.775
YQE_06624 Dendroctonus ponderosae YQE_06624 I 0.941
YQE_08737 Dendroctonus ponderosae YQE_08737 I 0.873
Aan_R014474 Calypte anna Aan_R014474 I 0.828
Afo_R008709 Aptenodytes forsteri Afo_R008709 I 0.971
Alligator_sinensis_CCG001823.1 Alligator sinensis Alligator_sinensis_CCG001823.1 I 0.873
Alligator_sinensis_CCG008910.1 Alligator sinensis Alligator_sinensis_CCG008910.1 I 0.971
Brh_R010414 Buceros rhinoceros Brh_R010414 I 0.971
Cflo_07183--XP_392838.3_APIME Camponotus floridanus Cflo_07183--XP_392838.3_APIME I 0.971
Cmyd_10005540 Chelonia mydas Cmyd_10005540 I 0.971
ENSP00000341551-D1 Bos grunniens ENSP00000341551-D1 I 0.971
ENSP00000381452 Macaca fascicularis ENSP00000381452 I 0.971
Gfo_R011803 Geospiza fortis Gfo_R011803 I 0.971
Gfo_R016223 Geospiza fortis Gfo_R016223 I 0.971
Hsal_09633--XP_392838.3_APIME Harpegnathos saltator Hsal_09633--XP_392838.3_APIME I 0.971
Myotis_brandtii_Smad4_10005924 Myotis brandtii Myotis_brandtii_Smad4_10005924 I 0.971
Ogr06720 Ophisaurus gracilis Ogr06720 I 0.961
Ogr14199 Ophisaurus gracilis Ogr14199 I 0.971
Pvit_01119 Pogona vitticeps Pvit_01119 I 0.971
e_gw.452.68.1 Branchiostoma floridae e_gw.452.68.1 I 0.951
fgenesh2_pg.scaffold_230000050 Branchiostoma floridae fgenesh2_pg.scaffold_230000050 I 0.912
Ocbimv22032358m.g Octopus bimaculoides Ocbimv22032358m.g I 0.912
Sakowv30001112m.g Saccoglossus kowalevskii Sakowv30001112m.g I 0.731
AAH84196 Xenopus laevis AAH84196 I 0.971
CLEC002594 Cimex lectularius CLEC002594 I 0.941
HHAL000393-PA Halyomorpha halys HHAL000393-PA I 0.931
HHAL000394-PA Halyomorpha halys HHAL000394-PA I 0.941
LCUP007928 Lucilia cuprina LCUP007928 I 0.951
LDEC015949 Leptinotarsa decemlineata LDEC015949 I 0.951
Sjc_0030450 Schistosoma japonicum Sjc_0030450 I 0.755
SMU15015494 Schmidtea mediterranea SMU15015494 I 0.784
smad4.1 Xenopus tropicalis XB-GENE-485691 I 0.971
smad4.2.S Xenopus laevis XB-GENE-5995204 I 0.951
smad4.2.L Xenopus laevis XB-GENE-6256010 I 0.951
smad4.1.L Xenopus laevis XB-GENE-865543 I 0.971
XP_002161797.1 Hydra magnipapillata XP_002161797.1 I 0.892
AALB009485 Anopheles albimanus AALB009485 I 0.941
AARA004719 Anopheles arabiensis AARA004719 I 0.961
AATE010695 Anopheles atroparvus AATE010695 I 0.961
ACHR000067 Anopheles christyi ACHR000067 I 0.961
ACOM037505 Anopheles coluzzii ACOM037505 I 0.961
ACUA025512 Anopheles culicifacies ACUA025512 I 0.961
ADIR002761 Anopheles dirus ADIR002761 I 0.961
AEPI002385 Anopheles epiroticus AEPI002385 I 0.961
AFAF011208 Anopheles farauti AFAF011208 I 0.961
AFUN009864 Anopheles funestus AFUN009864 I 0.961
AMAM019778 Anopheles maculatus AMAM019778 I 0.961
AMEC018109 Anopheles melas AMEC018109 I 0.926
AMEM015931 Anopheles merus AMEM015931 I 0.961
AMIN000723 Anopheles minimus AMIN000723 I 0.961
AQUA009305 Anopheles quadriannulatus AQUA009305 I 0.961
ASTEI00079 Anopheles stephensi ASTEI00079 I 0.961
BGLB014287 Biomphalaria glabrata BGLB014287 I 0.922
LLOJ008806 Lutzomyia longipalpis LLOJ008806 I 0.951
MDOA012885 Musca domestica MDOA012885 I 0.951
PPAI002168 Phlebotomus papatasi PPAI002168 I 0.951
ANCCAN_20978 Ancylostoma caninum ANCCAN_20978 I 0.706
ASIM_0001604001 Anisakis simplex ASIM_0001604001 I 0.814
ASU_13433 Ascaris suum ASU_13433 I 0.784
BTMF_0000404601 Brugia timori BTMF_0000404601 I 0.794
D915_03789 Fasciola hepatica D915_03789 I 0.775
D917_09719 Trichinella nativa D917_09719 I 0.824
D918_00298 Trichuris suis D918_00298 I 0.780
ECPE_0001832001 Echinostoma caproni ECPE_0001832001 I 0.784
EEL_0000707501 Elaeophora elaphi EEL_0000707501 I 0.784
GPUH_0001329001 Gongylonema pulchrum GPUH_0001329001 I 0.804
nAv.1.0.1.g00430 Acanthocheilonema viteae nAv.1.0.1.g00430 I 0.784
nDi.2.2.2.g01429 Dirofilaria immitis nDi.2.2.2.g01429 I 0.784
nLs.2.1.2.g01457 Litomosoides sigmodontis nLs.2.1.2.g01457 I 0.775
nOo.2.0.1.g00181 Onchocerca ochengi nOo.2.0.1.g00181 I 0.775
OESDEN_03018 Oesophagostomum dentatum OESDEN_03018 I 0.706
SMTD_0002197901 Schistosoma mattheei SMTD_0002197901 I 0.725
SROB_0000384401 Schistosoma rodhaini SROB_0000384401 I 0.716
SVUK_0000938201 Strongylus vulgaris SVUK_0000938201 I 0.706
T265_11013 Opisthorchis viverrini T265_11013 I 0.794
TCLT_0000917301 Thelazia callipaeda TCLT_0000917301 I 0.765
TELCIR_19676 Teladorsagia circumcincta TELCIR_19676 I 0.706
TMUE_s0006012700 Trichuris muris TMUE_s0006012700 I 0.833
TRE_0001987301 Trichobilharzia regenti TRE_0001987301 I 0.775
TTRE_0000855901 Trichuris trichiura TTRE_0000855901 I 0.824
NEMVEDRAFT_v1g116293 Nematostella vectensis NEMVEDRAFT_v1g116293 N 0.706
ECANG7_08262 Echinococcus canadensis ECANG7_08262 N 0.706