Irf8 (Rattus norvegicus)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSRNOG00000017869 T244369_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to interferon-gamma; mononuclear cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including defense response to protozoan; regulation of gene expression; and response to bacterium. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 32A and immunodeficiency 32B. Orthologous to human IRF8 (interferon regulatory factor 8). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF8
M03335_2.00 		Homo sapiens
HCGAAACYGAAACY
RGTTTCRGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_1 		0.971 0.971
IRF8
M03336_2.00 		Homo sapiens
HCGAAACCGAAACT
AGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_2 		0.971 0.971
IRF8
M05541_2.00 		Homo sapiens
NYGAAASYGAAASHN
NDSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX 		0.971 0.971
IRF8
M05543_2.00 		Homo sapiens
NCGAAACYGAAACYN
NRGTTTCRGTTTCGN		 SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX 		0.971 0.971
IRF8
M09236_2.00 		Homo sapiens
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B 		0.971 0.971
Irf8
M09246_2.00 		Mus musculus
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A 		0.971 0.971
IRF8
M10890_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ICSBP_Q6 		0.971 0.971
IRF8
M10891_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF8_Q6 		0.971 0.971
IRF8
M05542_2.00 		Homo sapiens
NYGAAASYGAAASYN
NRSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX 		0.971 0.971
IRF8
M05544_2.00 		Homo sapiens
NYGAAASYGAAACYD
HRGTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX 		0.971 0.971
Irf4
M00175_2.00 		Mus musculus
NNNYGAWASN
NSTWTCRNNN		 PBM
Badis et al.(2009)
Irf4_3476 		0.798 0.798
IRF4
M03334_2.00 		Homo sapiens
HCGAAACCGAAACYW
WRGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF4_1 		0.798 0.798
IRF4
M05539_2.00 		Homo sapiens
NYGAAACYGAAACYN
NRGTTTCRGTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX 		0.798 0.798
IRF4
M07978_2.00 		Homo sapiens
DNDVNNGWWVTGAVWVWN
NWBWBTCABWWCNNBHNH		 ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha 		0.798 0.798
IRF4
M09235_2.00 		Homo sapiens
NDWDRRGGAASTGARAVH
DBTYTCASTTCCYYHWHN		 Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A 		0.798 0.798
Irf4
M09243_2.00 		Mus musculus
NDAWVVRGAASTGARAVH
DBTYTCASTTCYBBWTHN		 Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A 		0.798 0.798
IRF4
M09595_2.00 		Homo sapiens
HNYGAAASYD
HRSTTTCRND		 Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465 		0.798 0.798
IRF4
M10885_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_07 		0.798 0.798
IRF4
M10886_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_08 		0.798 0.798
IRF4
M10887_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5_01 		0.798 0.798
IRF4
M10888_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5 		0.798 0.798
IRF4
M10889_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q6 		0.798 0.798
IRF4
M05540_2.00 		Homo sapiens
NYGAAASYGAWASHN
NDSTWTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX 		0.798 0.798
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000024069 IRF 9 113

Links

Other IRF family TFs
Other Rattus norvegicus TFs

161 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSCPOG00000027266 Cavia porcellus ENSCPOG00000027266 I 0.971
ENSMPUG00000008641 Mustela putorius furo ENSMPUG00000008641 I 0.971
Irf8 Mus musculus ENSMUSG00000041515 D 0.971
IRF8 Homo sapiens ENSG00000140968 D 0.971
Brh_R009589 Buceros rhinoceros Brh_R009589 I 0.971
ENSCSAG00000003142 Chlorocebus sabaeus ENSCSAG00000003142 I 0.962
IRF8 Gallus gallus ENSGALG00000005757 I 0.962
ENSNLEG00000011429 Nomascus leucogenys ENSNLEG00000011429 I 0.962
IRF8 Tupaia belangeri ENSTBEG00000013828 I 0.962
IRF8 Monodelphis domestica ENSMODG00000004572 I 0.962
Alligator_sinensis_CCG008430.1 Alligator sinensis Alligator_sinensis_CCG008430.1 I 0.962
ENSP00000268638-D1 Bos grunniens ENSP00000268638-D1 I 0.962
Cmyd_10021085 Chelonia mydas Cmyd_10021085 I 0.962
IRF8 Gorilla gorilla ENSGGOG00000028251 I 0.962
ENSSTOG00000028363 Ictidomys tridecemlineatus ENSSTOG00000028363 I 0.962
Afo_R011419 Aptenodytes forsteri Afo_R011419 I 0.962
ENSP00000268638 Macaca fascicularis ENSP00000268638 I 0.962
IRF8 Macaca mulatta ENSMMUG00000008125 I 0.962
ENSOARG00000011513 Ovis aries ENSOARG00000011513 I 0.962
ENSPANG00000024770 Papio anubis ENSPANG00000024770 I 0.962
IRF8 Ochotona princeps ENSOPRG00000002139 I 0.962
Tal_R007108 Tyto alba Tal_R007108 I 0.962
ENSPPYG00000007620 Pongo abelii ENSPPYG00000007620 I 0.962
IRF8 Pan troglodytes ENSPTRG00000008435 I 0.962
ENSPSIG00000011788 Pelodiscus sinensis ENSPSIG00000011788 I 0.962
IRF8 Bos taurus ENSBTAG00000017824 I 0.962
ENSSHAG00000006901 Sarcophilus harrisii ENSSHAG00000006901 I 0.962
IRF8 Callithrix jacchus ENSCJAG00000017331 I 0.962
IRF8 Felis catus ENSFCAG00000007615 I 0.952
Myotis_brandtii_IRF8_10035313 Myotis brandtii Myotis_brandtii_IRF8_10035313 I 0.952
ENSAMEG00000018268 Ailuropoda melanoleuca ENSAMEG00000018268 I 0.952
IRF8 Pteropus vampyrus ENSPVAG00000003758 I 0.952
Pvit_16863 Pogona vitticeps Pvit_16863 I 0.952
IRF8 Dasypus novemcinctus ENSDNOG00000038898 I 0.952
IRF8 Canis familiaris ENSCAFG00000019919 I 0.952
IRF8 Oryctolagus cuniculus ENSOCUG00000000536 I 0.952
IRF8 Myotis lucifugus ENSMLUG00000005109 I 0.952
IRF8 Otolemur garnettii ENSOGAG00000009262 I 0.952
IRF8 Anolis carolinensis ENSACAG00000005409 I 0.942
IRF8 Procavia capensis ENSPCAG00000004460 I 0.942
IRF8 Ornithorhynchus anatinus ENSOANG00000003741 I 0.942
Aan_R009222 Calypte anna Aan_R009222 I 0.942
IRF8 Loxodonta africana ENSLAFG00000010973 I 0.933
IRF8 Erinaceus europaeus ENSEEUG00000002644 I 0.933
ENSFALG00000006647 Ficedula albicollis ENSFALG00000006647 I 0.933
Gfo_R000501 Geospiza fortis Gfo_R000501 I 0.933
irf8.L Xenopus laevis XB-GENE-985949 I 0.923
Ogr08841 Ophisaurus gracilis Ogr08841 I 0.922
ENSLOCG00000001013 Lepisosteus oculatus ENSLOCG00000001013 I 0.913
ENSLACG00000005859 Latimeria chalumnae ENSLACG00000005859 I 0.904
ENSMICG00000012090 Microcebus murinus ENSMICG00000012090 I 0.898
ENSXMAG00000003082 Xiphophorus maculatus ENSXMAG00000003082 I 0.894
irf8 Takifugu rubripes ENSTRUG00000018213 I 0.894
irf8 Danio rerio ENSDARG00000056407 I 0.894
ENSAMXG00000003452 Astyanax mexicanus ENSAMXG00000003452 I 0.894
irf8 Tetraodon nigroviridis ENSTNIG00000009283 I 0.894
ENSGMOG00000003945 Gadus morhua ENSGMOG00000003945 I 0.885
ENSPFOG00000017639 Poecilia formosa ENSPFOG00000017639 I 0.885
ENSONIG00000005631 Oreochromis niloticus ENSONIG00000005631 I 0.875
irf8 Gasterosteus aculeatus ENSGACG00000015958 I 0.865
irf8 Oryzias latipes ENSORLG00000018216 I 0.865
ENSSSCG00000023184 Sus scrofa ENSSSCG00000023184 I 0.827
ENSPFOG00000015506 Poecilia formosa ENSPFOG00000015506 I 0.817
ENSXMAG00000017015 Xiphophorus maculatus ENSXMAG00000017015 I 0.817
IRF4 Choloepus hoffmanni ENSCHOG00000012417 I 0.804
ENSMICG00000011721 Microcebus murinus ENSMICG00000011721 I 0.804
ENSTSYG00000006495 Tarsius syrichta ENSTSYG00000006495 I 0.804
ENSMEUG00000002440 Macropus eugenii ENSMEUG00000002440 I 0.800
ENSSHAG00000015592 Sarcophilus harrisii ENSSHAG00000015592 I 0.800
IRF4 Anolis carolinensis ENSACAG00000017711 I 0.800
Pvit_05673 Pogona vitticeps Pvit_05673 I 0.800
IRF4 Tursiops truncatus ENSTTRG00000001849 I 0.800
IRF4 Monodelphis domestica ENSMODG00000008383 I 0.800
Irf4 Rattus norvegicus ENSRNOG00000061070 I 0.798
Ogr05775 Ophisaurus gracilis Ogr05775 I 0.798
Irf4 Mus musculus ENSMUSG00000021356 D 0.798
ENSP00000370343 Macaca fascicularis ENSP00000370343 I 0.797
Tal_R010571 Tyto alba Tal_R010571 I 0.793
IRF4 Gorilla gorilla ENSGGOG00000012342 I 0.790
ENSSTOG00000011470 Ictidomys tridecemlineatus ENSSTOG00000011470 I 0.790
IRF4 Pteropus vampyrus ENSPVAG00000005078 I 0.790
IRF4 Myotis lucifugus ENSMLUG00000010058 I 0.790
IRF4 Felis catus ENSFCAG00000022941 I 0.790
ENSPPYG00000016161 Pongo abelii ENSPPYG00000016161 I 0.790
ENSAMEG00000005976 Ailuropoda melanoleuca ENSAMEG00000005976 I 0.790
IRF4 Pan troglodytes ENSPTRG00000017656 I 0.790
Brh_R000433 Buceros rhinoceros Brh_R000433 I 0.790
ENSPSIG00000011619 Pelodiscus sinensis ENSPSIG00000011619 I 0.790
irf4b Tetraodon nigroviridis ENSTNIG00000008222 I 0.790
IRF4 Loxodonta africana ENSLAFG00000017235 I 0.790
IRF4 Macaca mulatta ENSMMUG00000018513 I 0.790
IRF4 Echinops telfairi ENSETEG00000018472 I 0.790
IRF4 Cavia porcellus ENSCPOG00000003562 I 0.790
IRF4 Callithrix jacchus ENSCJAG00000019524 I 0.790
ENSCSAG00000007164 Chlorocebus sabaeus ENSCSAG00000007164 I 0.790
ENSOARG00000003822 Ovis aries ENSOARG00000003822 I 0.790
IRF4 Tupaia belangeri ENSTBEG00000012240 I 0.790
IRF4 Homo sapiens ENSG00000137265 D 0.790
IRF4 Otolemur garnettii ENSOGAG00000014574 I 0.790
Irf4 Dipodomys ordii ENSDORG00000014895 I 0.790
ENSNLEG00000010631 Nomascus leucogenys ENSNLEG00000010631 I 0.790
irf4a Takifugu rubripes ENSTRUG00000011568 I 0.790
IRF4 Ochotona princeps ENSOPRG00000012683 I 0.790
IRF4 Bos taurus ENSBTAG00000002929 I 0.790
ENSMPUG00000007848 Mustela putorius furo ENSMPUG00000007848 I 0.790
IRF4 Equus caballus ENSECAG00000016808 I 0.790
ENSP00000370343-D1 Bos grunniens ENSP00000370343-D1 I 0.790
Afo_R010468 Aptenodytes forsteri Afo_R010468 I 0.789
ENSPANG00000023389 Papio anubis ENSPANG00000023389 I 0.789
Cmyd_10011521 Chelonia mydas Cmyd_10011521 I 0.781
Gfo_R003357 Geospiza fortis Gfo_R003357 I 0.781
Alligator_sinensis_CCG015622.1 Alligator sinensis Alligator_sinensis_CCG015622.1 I 0.781
Afo_R014746 Aptenodytes forsteri Afo_R014746 I 0.781
Aan_R012662 Calypte anna Aan_R012662 I 0.781
IRF4 Taeniopygia guttata ENSTGUG00000002144 I 0.781
IRF4 Oryctolagus cuniculus ENSOCUG00000009374 I 0.781
ENSONIG00000009637 Oreochromis niloticus ENSONIG00000009637 I 0.781
ENSGMOG00000016994 Gadus morhua ENSGMOG00000016994 I 0.781
ENSFALG00000013071 Ficedula albicollis ENSFALG00000013071 I 0.781
ENSAPLG00000014646 Anas platyrhynchos ENSAPLG00000014646 I 0.781
irf4a Oryzias latipes ENSORLG00000017242 I 0.781
ENSGALG00000012830 Gallus gallus ENSGALG00000012830 I 0.781
irf4a Tetraodon nigroviridis ENSTNIG00000005370 I 0.779
IRF4 Erinaceus europaeus ENSEEUG00000007703 I 0.776
Gfo_R005312 Geospiza fortis Gfo_R005312 I 0.772
Aan_R015695 Calypte anna Aan_R015695 I 0.772
ENSLOCG00000013008 Lepisosteus oculatus ENSLOCG00000013008 I 0.771
irf4b Takifugu rubripes ENSTRUG00000002946 I 0.769
irf4b Gasterosteus aculeatus ENSGACG00000004966 I 0.769
ENSAMXG00000016370 Astyanax mexicanus ENSAMXG00000016370 I 0.769
Myotis_brandtii_Irf4_10020370 Myotis brandtii Myotis_brandtii_Irf4_10020370 I 0.767
ENSONIG00000006398 Oreochromis niloticus ENSONIG00000006398 I 0.762
irf4b Danio rerio ENSDARG00000055374 I 0.762
ENSPFOG00000000657 Poecilia formosa ENSPFOG00000000657 I 0.762
irf4a Danio rerio ENSDARG00000006560 I 0.762
ENSGMOG00000005047 Gadus morhua ENSGMOG00000005047 I 0.762
ENSXMAG00000006246 Xiphophorus maculatus ENSXMAG00000006246 I 0.762
irf4b Oryzias latipes ENSORLG00000012712 I 0.760
ENSLACG00000007228 Latimeria chalumnae ENSLACG00000007228 I 0.760
IRF4 Ornithorhynchus anatinus ENSOANG00000006326 I 0.754
irf4 Xenopus tropicalis XB-GENE-988321 I 0.752
irf10 Danio rerio ENSDARG00000027658 I 0.752
ENSAMXG00000006093 Astyanax mexicanus ENSAMXG00000006093 I 0.752
ENSLOCG00000001187 Lepisosteus oculatus ENSLOCG00000001187 I 0.750
irf4a Gasterosteus aculeatus ENSGACG00000016461 I 0.743
ENSFALG00000005506 Ficedula albicollis ENSFALG00000005506 I 0.743
ENSLOCG00000003532 Lepisosteus oculatus ENSLOCG00000003532 I 0.743
ENSGALG00000006448 Gallus gallus ENSGALG00000006448 I 0.743
ENSTGUG00000006609 Taeniopygia guttata ENSTGUG00000006609 I 0.740
ENSPSIG00000003518 Pelodiscus sinensis ENSPSIG00000003518 I 0.732
ENSLACG00000004633 Latimeria chalumnae ENSLACG00000004633 I 0.731
ENSAPLG00000010348 Anas platyrhynchos ENSAPLG00000010348 I 0.723
ENSMODG00000019483 Monodelphis domestica ENSMODG00000019483 I 0.721
ENSTNIG00000002469 Tetraodon nigroviridis ENSTNIG00000002469 I 0.714
ENSAMXG00000004911 Astyanax mexicanus ENSAMXG00000004911 I 0.713
irf9 Danio rerio ENSDARG00000016457 I 0.712
Cmyd_10009547 Chelonia mydas Cmyd_10009547 I 0.707
Ogr04948 Ophisaurus gracilis Ogr04948 N 0.705
ENSAMXG00000012775 Astyanax mexicanus ENSAMXG00000012775 I 0.705
ENSONIG00000006624 Oreochromis niloticus ENSONIG00000006624 I 0.702
irf10 Xenopus tropicalis XB-GENE-1033046 I 0.702