Irf8 (Mus musculus)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSMUSG00000041515 T244224_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf8
M09246_2.00
Mus musculus
NDDDRRGGAASTGAAASYNN

NNRSTTTCASTTCCYYHHHN
Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF8
M03335_2.00
Homo sapiens
HCGAAACYGAAACY

RGTTTCRGTTTCGD
SELEX
Jolma et al.(2013)
IRF8_1
0.845 0.845
IRF8
M03336_2.00
Homo sapiens
HCGAAACCGAAACT

AGTTTCGGTTTCGD
SELEX
Jolma et al.(2013)
IRF8_2
0.845 0.845
IRF8
M05541_2.00
Homo sapiens
NYGAAASYGAAASHN

NDSTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX
0.981 0.981
IRF8
M05543_2.00
Homo sapiens
NCGAAACYGAAACYN

NRGTTTCRGTTTCGN
SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX
0.845 0.845
IRF8
M09236_2.00
Homo sapiens
NDDDRRGGAASTGAAASYNN

NNRSTTTCASTTCCYYHHHN
Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B
0.845 0.845
IRF8
M10890_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ICSBP_Q6
0.845 0.845
IRF8
M10891_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF8_Q6
0.845 0.845
IRF8
M05542_2.00
Homo sapiens
NYGAAASYGAAASYN

NRSTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX
0.845 0.845
IRF8
M05544_2.00
Homo sapiens
NYGAAASYGAAACYD

HRGTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX
0.845 0.845
Irf4
M00175_2.00
Mus musculus
NNNYGAWASN

NSTWTCRNNN
PBM
Badis et al.(2009)
Irf4_3476
0.798 0.798
IRF4
M03334_2.00
Homo sapiens
HCGAAACCGAAACYW

WRGTTTCGGTTTCGD
SELEX
Jolma et al.(2013)
IRF4_1
0.798 0.798
IRF4
M05539_2.00
Homo sapiens
NYGAAACYGAAACYN

NRGTTTCRGTTTCRN
SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX
0.798 0.798
IRF4
M07978_2.00
Homo sapiens
DNDVNNGWWVTGAVWVWN

NWBWBTCABWWCNNBHNH
ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha
0.798 0.798
IRF4
M09235_2.00
Homo sapiens
NDWDRRGGAASTGARAVH

DBTYTCASTTCCYYHWHN
Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A
0.798 0.798
Irf4
M09243_2.00
Mus musculus
NDAWVVRGAASTGARAVH

DBTYTCASTTCYBBWTHN
Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A
0.798 0.798
IRF4
M09595_2.00
Homo sapiens
HNYGAAASYD

HRSTTTCRND
Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465
0.798 0.798
IRF4
M10885_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_07
0.798 0.798
IRF4
M10886_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_08
0.798 0.798
IRF4
M10887_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q5_01
0.798 0.798
IRF4
M10888_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q5
0.798 0.798
IRF4
M10889_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q6
0.798 0.798
IRF4
M05540_2.00
Homo sapiens
NYGAAASYGAWASHN

NDSTWTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX
0.798 0.798
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000040245 IRF 9 113
ENSMUSP00000125029 IRF 9 113
ENSMUSP00000125443 IRF 9 111
ENSMUSP00000125447 IRF 1 56

Links

Other IRF family TFs
Other Mus musculus TFs

173 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
IRF8 Tursiops truncatus ENSTTRG00000016024 I 1.000
IRF8 Homo sapiens ENSG00000140968 D 1.000
XP_002934991 Xenopus tropicalis XP_002934991 I 1.000
IRF8 Callithrix jacchus ENSCJAG00000017331 I 0.990
ENSOARG00000011513 Ovis aries ENSOARG00000011513 I 0.990
ENSNLEG00000011429 Nomascus leucogenys ENSNLEG00000011429 I 0.990
IRF8 Macaca mulatta ENSMMUG00000008125 I 0.990
IRF8 Gorilla gorilla ENSGGOG00000028251 I 0.990
ENSCSAG00000003142 Chlorocebus sabaeus ENSCSAG00000003142 I 0.990
IRF8 Bos taurus ENSBTAG00000017824 I 0.990
ENSPANG00000024770 Papio anubis ENSPANG00000024770 I 0.990
ENSP00000268638-D1 Bos grunniens ENSP00000268638-D1 I 0.990
ENSP00000268638 Macaca fascicularis ENSP00000268638 I 0.990
IRF8 Pan troglodytes ENSPTRG00000008435 I 0.990
ENSSTOG00000028363 Ictidomys tridecemlineatus ENSSTOG00000028363 I 0.990
ENSPPYG00000007620 Pongo abelii ENSPPYG00000007620 I 0.990
IRF8 Dasypus novemcinctus ENSDNOG00000038898 I 0.981
IRF8 Felis catus ENSFCAG00000007615 I 0.981
Myotis_brandtii_IRF8_10035313 Myotis brandtii Myotis_brandtii_IRF8_10035313 I 0.981
IRF8 Myotis lucifugus ENSMLUG00000005109 I 0.981
IRF8 Oryctolagus cuniculus ENSOCUG00000000536 I 0.981
Brh_R009589 Buceros rhinoceros Brh_R009589 I 0.981
IRF8 Pteropus vampyrus ENSPVAG00000003758 I 0.981
IRF8 Otolemur garnettii ENSOGAG00000009262 I 0.981
IRF8 Canis familiaris ENSCAFG00000019919 I 0.981
ENSAMEG00000018268 Ailuropoda melanoleuca ENSAMEG00000018268 I 0.981
Irf8 Rattus norvegicus ENSRNOG00000017869 I 0.971
ENSPSIG00000011788 Pelodiscus sinensis ENSPSIG00000011788 I 0.971
Cmyd_10021085 Chelonia mydas Cmyd_10021085 I 0.971
ENSSHAG00000006901 Sarcophilus harrisii ENSSHAG00000006901 I 0.971
IRF8 Gallus gallus ENSGALG00000005757 I 0.971
ENSCPOG00000027266 Cavia porcellus ENSCPOG00000027266 I 0.971
Alligator_sinensis_CCG008430.1 Alligator sinensis Alligator_sinensis_CCG008430.1 I 0.971
IRF8 Tupaia belangeri ENSTBEG00000013828 I 0.971
Afo_R011419 Aptenodytes forsteri Afo_R011419 I 0.971
IRF8 Monodelphis domestica ENSMODG00000004572 I 0.971
IRF8 Ornithorhynchus anatinus ENSOANG00000003741 I 0.971
Tal_R007108 Tyto alba Tal_R007108 I 0.971
IRF8 Procavia capensis ENSPCAG00000004460 I 0.971
IRF8 Ochotona princeps ENSOPRG00000002139 I 0.971
IRF8 Anolis carolinensis ENSACAG00000005409 I 0.971
IRF8 Erinaceus europaeus ENSEEUG00000002644 I 0.962
Pvit_16863 Pogona vitticeps Pvit_16863 I 0.962
ENSMPUG00000008641 Mustela putorius furo ENSMPUG00000008641 I 0.962
IRF8 Loxodonta africana ENSLAFG00000010973 I 0.962
ENSMICG00000012090 Microcebus murinus ENSMICG00000012090 I 0.959
Aan_R009222 Calypte anna Aan_R009222 I 0.952
Ogr08841 Ophisaurus gracilis Ogr08841 I 0.951
IRF8 Equus caballus ENSECAG00000015449 I 0.949
Gfo_R000501 Geospiza fortis Gfo_R000501 I 0.942
ENSFALG00000006647 Ficedula albicollis ENSFALG00000006647 I 0.942
irf8.L Xenopus laevis XB-GENE-985949 I 0.923
ENSLOCG00000001013 Lepisosteus oculatus ENSLOCG00000001013 I 0.923
ENSLACG00000005859 Latimeria chalumnae ENSLACG00000005859 I 0.913
ENSGMOG00000003945 Gadus morhua ENSGMOG00000003945 I 0.904
ENSAMXG00000003452 Astyanax mexicanus ENSAMXG00000003452 I 0.894
ENSXMAG00000003082 Xiphophorus maculatus ENSXMAG00000003082 I 0.894
irf8 Danio rerio ENSDARG00000056407 I 0.894
ENSPFOG00000017639 Poecilia formosa ENSPFOG00000017639 I 0.885
ENSONIG00000005631 Oreochromis niloticus ENSONIG00000005631 I 0.875
irf8 Takifugu rubripes ENSTRUG00000018213 I 0.875
irf8 Tetraodon nigroviridis ENSTNIG00000009283 I 0.875
irf8 Gasterosteus aculeatus ENSGACG00000015958 I 0.865
irf8 Oryzias latipes ENSORLG00000018216 I 0.865
ENSSSCG00000023184 Sus scrofa ENSSSCG00000023184 I 0.856
IRF8 Meleagris gallopavo ENSMGAG00000007344 N 0.828
Irf8 Dipodomys ordii ENSDORG00000015963 N 0.828
IRF4 Anolis carolinensis ENSACAG00000017711 I 0.819
Ogr05775 Ophisaurus gracilis Ogr05775 I 0.817
ENSXMAG00000017015 Xiphophorus maculatus ENSXMAG00000017015 I 0.817
ENSPFOG00000015506 Poecilia formosa ENSPFOG00000015506 I 0.817
Brh_R000433 Buceros rhinoceros Brh_R000433 I 0.810
ENSMICG00000011721 Microcebus murinus ENSMICG00000011721 I 0.804
ENSTSYG00000006495 Tarsius syrichta ENSTSYG00000006495 I 0.804
IRF4 Choloepus hoffmanni ENSCHOG00000012417 I 0.804
IRF4 Tursiops truncatus ENSTTRG00000001849 I 0.800
ENSONIG00000009637 Oreochromis niloticus ENSONIG00000009637 I 0.800
Pvit_05673 Pogona vitticeps Pvit_05673 I 0.800
Gfo_R003357 Geospiza fortis Gfo_R003357 I 0.800
IRF4 Taeniopygia guttata ENSTGUG00000002144 I 0.800
Afo_R014746 Aptenodytes forsteri Afo_R014746 I 0.800
Alligator_sinensis_CCG015622.1 Alligator sinensis Alligator_sinensis_CCG015622.1 I 0.800
ENSSHAG00000015592 Sarcophilus harrisii ENSSHAG00000015592 I 0.800
Cmyd_10011521 Chelonia mydas Cmyd_10011521 I 0.800
irf4a Takifugu rubripes ENSTRUG00000011568 I 0.800
Aan_R012662 Calypte anna Aan_R012662 I 0.800
ENSAPLG00000014646 Anas platyrhynchos ENSAPLG00000014646 I 0.800
ENSGMOG00000016994 Gadus morhua ENSGMOG00000016994 I 0.800
ENSGALG00000012830 Gallus gallus ENSGALG00000012830 I 0.800
ENSFALG00000013071 Ficedula albicollis ENSFALG00000013071 I 0.800
IRF4 Monodelphis domestica ENSMODG00000008383 I 0.800
ENSMEUG00000002440 Macropus eugenii ENSMEUG00000002440 I 0.800
ENSP00000370343 Macaca fascicularis ENSP00000370343 I 0.797
Tal_R010571 Tyto alba Tal_R010571 I 0.793
IRF8 Vicugna pacos ENSVPAG00000006643 I 0.793
ENSSTOG00000011470 Ictidomys tridecemlineatus ENSSTOG00000011470 I 0.790
IRF4 Pteropus vampyrus ENSPVAG00000005078 I 0.790
IRF4 Macaca mulatta ENSMMUG00000018513 I 0.790
IRF4 Bos taurus ENSBTAG00000002929 I 0.790
Irf4 Rattus norvegicus ENSRNOG00000061070 I 0.790
IRF4 Loxodonta africana ENSLAFG00000017235 I 0.790
ENSMPUG00000007848 Mustela putorius furo ENSMPUG00000007848 I 0.790
IRF4 Tupaia belangeri ENSTBEG00000012240 I 0.790
IRF4 Otolemur garnettii ENSOGAG00000014574 I 0.790
irf4b Tetraodon nigroviridis ENSTNIG00000008222 I 0.790
IRF4 Ochotona princeps ENSOPRG00000012683 I 0.790
ENSLOCG00000013008 Lepisosteus oculatus ENSLOCG00000013008 I 0.790
IRF4 Cavia porcellus ENSCPOG00000003562 I 0.790
IRF4 Myotis lucifugus ENSMLUG00000010058 I 0.790
ENSCSAG00000007164 Chlorocebus sabaeus ENSCSAG00000007164 I 0.790
IRF4 Pan troglodytes ENSPTRG00000017656 I 0.790
IRF4 Felis catus ENSFCAG00000022941 I 0.790
ENSNLEG00000010631 Nomascus leucogenys ENSNLEG00000010631 I 0.790
ENSAMEG00000005976 Ailuropoda melanoleuca ENSAMEG00000005976 I 0.790
IRF4 Echinops telfairi ENSETEG00000018472 I 0.790
IRF4 Equus caballus ENSECAG00000016808 I 0.790
ENSOARG00000003822 Ovis aries ENSOARG00000003822 I 0.790
IRF4 Callithrix jacchus ENSCJAG00000019524 I 0.790
ENSP00000370343-D1 Bos grunniens ENSP00000370343-D1 I 0.790
Irf4 Mus musculus ENSMUSG00000021356 D 0.790
IRF4 Gorilla gorilla ENSGGOG00000012342 I 0.790
Irf4 Dipodomys ordii ENSDORG00000014895 I 0.790
ENSPSIG00000011619 Pelodiscus sinensis ENSPSIG00000011619 I 0.790
ENSPPYG00000016161 Pongo abelii ENSPPYG00000016161 I 0.790
IRF4 Homo sapiens ENSG00000137265 D 0.790
ENSPANG00000023389 Papio anubis ENSPANG00000023389 I 0.789
Afo_R010468 Aptenodytes forsteri Afo_R010468 I 0.789
irf4b Takifugu rubripes ENSTRUG00000002946 I 0.788
ENSAMXG00000016370 Astyanax mexicanus ENSAMXG00000016370 I 0.788
irf4a Tetraodon nigroviridis ENSTNIG00000005370 I 0.788
IRF4 Oryctolagus cuniculus ENSOCUG00000009374 I 0.781
ENSONIG00000006398 Oreochromis niloticus ENSONIG00000006398 I 0.781
ENSPFOG00000000657 Poecilia formosa ENSPFOG00000000657 I 0.781
irf4a Danio rerio ENSDARG00000006560 I 0.781
irf4b Danio rerio ENSDARG00000055374 I 0.781
ENSXMAG00000006246 Xiphophorus maculatus ENSXMAG00000006246 I 0.781
irf4a Oryzias latipes ENSORLG00000017242 I 0.781
irf4b Oryzias latipes ENSORLG00000012712 I 0.779
irf4b Gasterosteus aculeatus ENSGACG00000004966 I 0.779
IRF4 Procavia capensis ENSPCAG00000010586 I 0.776
IRF4 Erinaceus europaeus ENSEEUG00000007703 I 0.776
Gfo_R005312 Geospiza fortis Gfo_R005312 I 0.772
Aan_R015695 Calypte anna Aan_R015695 I 0.772
ENSAMXG00000006093 Astyanax mexicanus ENSAMXG00000006093 I 0.771
irf10 Danio rerio ENSDARG00000027658 I 0.771
ENSGMOG00000005047 Gadus morhua ENSGMOG00000005047 I 0.771
Myotis_brandtii_Irf4_10020370 Myotis brandtii Myotis_brandtii_Irf4_10020370 I 0.767
ENSLOCG00000003532 Lepisosteus oculatus ENSLOCG00000003532 I 0.762
IRF4 Ornithorhynchus anatinus ENSOANG00000006326 I 0.754
irf4 Xenopus tropicalis XB-GENE-988321 I 0.752
irf4a Gasterosteus aculeatus ENSGACG00000016461 I 0.752
ENSLACG00000007228 Latimeria chalumnae ENSLACG00000007228 I 0.752
ENSLOCG00000001187 Lepisosteus oculatus ENSLOCG00000001187 I 0.750
ENSGALG00000006448 Gallus gallus ENSGALG00000006448 I 0.743
ENSFALG00000005506 Ficedula albicollis ENSFALG00000005506 I 0.743
ENSLACG00000004633 Latimeria chalumnae ENSLACG00000004633 I 0.740
ENSAMXG00000004911 Astyanax mexicanus ENSAMXG00000004911 I 0.733
ENSTGUG00000006609 Taeniopygia guttata ENSTGUG00000006609 I 0.733
ENSMODG00000019483 Monodelphis domestica ENSMODG00000019483 I 0.733
ENSPSIG00000003518 Pelodiscus sinensis ENSPSIG00000003518 I 0.732
irf9 Danio rerio ENSDARG00000016457 I 0.731
ENSTNIG00000002469 Tetraodon nigroviridis ENSTNIG00000002469 I 0.714
ENSAMXG00000002697 Astyanax mexicanus ENSAMXG00000002697 I 0.714
ENSSHAG00000012864 Sarcophilus harrisii ENSSHAG00000012864 I 0.714
irf10 Xenopus tropicalis XB-GENE-1033046 I 0.712
ENSAPLG00000010348 Anas platyrhynchos ENSAPLG00000010348 I 0.711
Cmyd_10009547 Chelonia mydas Cmyd_10009547 I 0.707
ENSAMXG00000012775 Astyanax mexicanus ENSAMXG00000012775 I 0.705
irf10 Tetraodon nigroviridis ENSTNIG00000012613 I 0.705
irf10 Takifugu rubripes ENSTRUG00000002917 I 0.702
ENSONIG00000006624 Oreochromis niloticus ENSONIG00000006624 I 0.702
irf9 Gasterosteus aculeatus ENSGACG00000001697 I 0.702