nhr-123 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003713 T306235_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in dorsal nerve cord; head neurons; intestine; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-182
M00701_2.00 		Caenorhabditis elegans
DWBYGTGWCH
DGWCACRVWH		 PBM
Narasimhan et al.(2015)
pTH10779 		0.868 0.529
nhr-182
M00702_2.00 		Caenorhabditis elegans
NNNHRTRNHN
NDNYAYDNNN		 PBM
Narasimhan et al.(2015)
pTH6106 		0.868 0.529
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
M02H5.7 Nuclear receptor 23 92

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

31 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
nhr-98 Caenorhabditis elegans WBGene00003688 I 0.992
nhr-99 Caenorhabditis elegans WBGene00003689 I 0.980
nhr-201 Caenorhabditis elegans WBGene00019741 I 0.969
nhr-202 Caenorhabditis elegans WBGene00019742 I 0.965
CBN17580 Caenorhabditis brenneri CBN17580 N 0.939
nhr-203 Caenorhabditis elegans WBGene00019743 N 0.934
CRE09225 Caenorhabditis remanei CRE09225 N 0.905
CBG01353 Caenorhabditis briggsae CBG01353 I 0.900
CRE09227 Caenorhabditis remanei CRE09227 N 0.885
CBG01352 Caenorhabditis briggsae CBG01352 I 0.883
nhr-182 Caenorhabditis elegans WBGene00018265 D 0.868
CBG17898 Caenorhabditis briggsae CBG17898 I 0.855
CRE09224 Caenorhabditis remanei CRE09224 N 0.853
CBG01357 Caenorhabditis briggsae CBG01357 N 0.845
CBG01359 Caenorhabditis briggsae CBG01359 N 0.842
CBN03087 Caenorhabditis brenneri CBN03087 I 0.834
CBG04928 Caenorhabditis briggsae CBG04928 I 0.802
nhr-117 Caenorhabditis elegans WBGene00003707 I 0.792
CRE08749 Caenorhabditis remanei CRE08749 I 0.784
CRE15097 Caenorhabditis remanei CRE15097 I 0.783
CRE10693 Caenorhabditis remanei CRE10693 I 0.783
CJA19466 Caenorhabditis japonica CJA19466 I 0.783
CBN13200 Caenorhabditis brenneri CBN13200 I 0.783
CRE14845 Caenorhabditis remanei CRE14845 I 0.773
CBG06387 Caenorhabditis briggsae CBG06387 I 0.768
CBN00299 Caenorhabditis brenneri CBN00299 I 0.763
CRE09222 Caenorhabditis remanei CRE09222 I 0.757
CBG19144 Caenorhabditis briggsae CBG19144 I 0.757
nhr-55 Caenorhabditis elegans WBGene00003645 I 0.756
nhr-130 Caenorhabditis elegans WBGene00003720 I 0.754
CBG27350 Caenorhabditis briggsae CBG27350 I 0.748