gli2a (Danio rerio)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSDARG00000025641 T090867_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; nervous system development; and regionalization. Located in non-motile cilium and nucleus. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and neural plate. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Gli3
M01022_2.00 		Mus musculus
NGACCACCCNN
NNGGGTGGTCN		 PBM
Peterson et al.(2012)
Gli3 		0.815 0.948
Gli3
M08023_2.00 		Mus musculus
RGVCCACCCAS
STGGGTGGBCY		 ChIP-seq
Chen et al.(2011)
GSE11062_Gli3 		0.815 0.948
Gli3
M09512_2.00 		Mus musculus
RGACCACCCASR
YSTGGGTGGTCY		 Misc
Heinz et al.(2010)
Limb-GLI3_GSE11077 		0.815 0.948
GLI3
M04416_2.00 		Homo sapiens
VGACCACCCACVNHG
CDNBGTGGGTGGTCB		 SELEX
Yin et al.(2017)
GLI3_eDBD_HT-SELEX 		0.769 0.948
GLI3
M02642_2.00 		Homo sapiens
GACCACCCANK
MNTGGGTGGTC		 SELEX
Hallikas et al.(2006)
GLI3 		0.769 0.948
GLI3
M08875_2.00 		Homo sapiens
VRACCACCCAV
BTGGGTGGTYB		 Misc
Kulakovskiy et al.(2013)
GLI3_HUMAN.H11MO.0.B 		0.769 0.948
GLI3
M10167_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI3_01 		0.769 0.948
GLI3
M10168_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI3_Q5_01 		0.769 0.948
GLI3
M04417_2.00 		Homo sapiens
CWHBGTGGGTGGTCY
RGACCACCCACVDWG		 SELEX
Yin et al.(2017)
GLI3_eDBD_Methyl-HT-SELEX 		0.769 0.948
Gli2
M01024_2.00 		Mus musculus
NGACCACCYN
NRGGTGGTCN		 PBM
Peterson et al.(2012)
Gli2 		0.763 0.939
GLI2
M02875_2.00 		Homo sapiens
GMCCACMCANVNHB
VDNBNTGKGTGGKC		 SELEX
Jolma et al.(2013)
GLI2_1 		0.763 0.939
GLI2
M02876_2.00 		Homo sapiens
GCGACCACVCWR
YWGBGTGGTCGC		 SELEX
Jolma et al.(2013)
GLI2_2 		0.763 0.939
GLI2
M02732_2.00 		Homo sapiens
GACCACMCAN
NTGKGTGGTC		 SELEX
Jolma et al.(2010)
GLI2_monomer 		0.763 0.939
GLI2
M04402_2.00 		Homo sapiens
VGACCACCCACVDHG
CDHBGTGGGTGGTCB		 SELEX
Yin et al.(2017)
GLI2_eDBD_HT-SELEX 		0.763 0.939
GLI2
M02641_2.00 		Homo sapiens
GACCACCCAHG
CDTGGGTGGTC		 SELEX
Hallikas et al.(2006)
GLI2 		0.763 0.939
GLI2
M10114_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI2_Q3 		0.763 0.939
GLI2
M10115_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI2_Q6 		0.763 0.939
GLI2
M04403_2.00 		Homo sapiens
RGACCACCCACVWWG
CWWBGTGGGTGGTCY		 SELEX
Yin et al.(2017)
GLI2_eDBD_Methyl-HT-SELEX 		0.763 0.939
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000010693 C2H2 ZF 402 427
ENSDARP00000010693 C2H2 ZF 435 462
ENSDARP00000010693 C2H2 ZF 468 492
ENSDARP00000010693 C2H2 ZF 498 523
ENSDARP00000010693 C2H2 ZF 529 554

Links

Other C2H2 ZF family TFs
Other Danio rerio TFs

134 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSLOCG00000002028 Lepisosteus oculatus ENSLOCG00000002028 I 0.823
ENSONIG00000004472 Oreochromis niloticus ENSONIG00000004472 I 0.823
ENSONIG00000003608 Oreochromis niloticus ENSONIG00000003608 I 0.821
ENSGMOG00000010335 Gadus morhua ENSGMOG00000010335 I 0.820
ENSPFOG00000014778 Poecilia formosa ENSPFOG00000014778 I 0.820
Gli3 Rattus norvegicus ENSRNOG00000014395 I 0.815
GLI3 Cavia porcellus ENSCPOG00000013233 I 0.815
ENSSTOG00000020844 Ictidomys tridecemlineatus ENSSTOG00000020844 I 0.815
Gli3 Mus musculus ENSMUSG00000021318 D 0.815
gli2b Takifugu rubripes ENSTRUG00000001954 I 0.814
gli2b Gasterosteus aculeatus ENSGACG00000001547 I 0.814
ENSGMOG00000007975 Gadus morhua ENSGMOG00000007975 I 0.813
gli1 Takifugu rubripes ENSTRUG00000014998 I 0.813
gli1 Gasterosteus aculeatus ENSGACG00000006458 I 0.813
ENSONIG00000005084 Oreochromis niloticus ENSONIG00000005084 I 0.811
ENSPFOG00000006269 Poecilia formosa ENSPFOG00000006269 I 0.811
gli1 Tetraodon nigroviridis ENSTNIG00000007058 I 0.811
gli1 Oryzias latipes ENSORLG00000005455 I 0.811
ENSXMAG00000017965 Xiphophorus maculatus ENSXMAG00000017965 I 0.811
gli2.S Xenopus laevis XB-GENE-6251939 I 0.808
fgenesh2_pg.scaffold_169000072 Branchiostoma floridae fgenesh2_pg.scaffold_169000072 I 0.804
gli2.L Xenopus laevis XB-GENE-17342592 I 0.804
fgenesh2_pg.scaffold_137000068 Branchiostoma floridae fgenesh2_pg.scaffold_137000068 I 0.804
ENSAMXG00000006646 Astyanax mexicanus ENSAMXG00000006646 I 0.777
GLI2 Anolis carolinensis ENSACAG00000004133 I 0.777
ENSAMXG00000003125 Astyanax mexicanus ENSAMXG00000003125 I 0.777
gli2b Takifugu rubripes ENSTRUG00000010444 I 0.777
Pvit_06470 Pogona vitticeps Pvit_06470 I 0.777
gli2b Danio rerio ENSDARG00000020884 I 0.777
Ogr02489 Ophisaurus gracilis Ogr02489 I 0.777
GLI2 Meleagris gallopavo ENSMGAG00000011872 I 0.775
ENSPSIG00000008752 Pelodiscus sinensis ENSPSIG00000008752 I 0.775
GLI2 Taeniopygia guttata ENSTGUG00000004599 I 0.775
GLI2 Gallus gallus ENSGALG00000011630 I 0.775
ENSFALG00000013217 Ficedula albicollis ENSFALG00000013217 I 0.775
Tal_R006208 Tyto alba Tal_R006208 I 0.775
Brh_R010932 Buceros rhinoceros Brh_R010932 I 0.775
ENSAPLG00000015141 Anas platyrhynchos ENSAPLG00000015141 I 0.775
Gfo_R001212 Geospiza fortis Gfo_R001212 I 0.775
Aan_R003640 Calypte anna Aan_R003640 I 0.775
Afo_R006826 Aptenodytes forsteri Afo_R006826 I 0.775
Cmyd_10009086 Chelonia mydas Cmyd_10009086 I 0.775
ENSPFOG00000005116 Poecilia formosa ENSPFOG00000005116 I 0.774
ENSXMAG00000006443 Xiphophorus maculatus ENSXMAG00000006443 I 0.774
gli3 Danio rerio ENSDARG00000052131 I 0.771
ENSPSIG00000017804 Pelodiscus sinensis ENSPSIG00000017804 I 0.769
GLI3 Ochotona princeps ENSOPRG00000011225 I 0.769
GLI3 Procavia capensis ENSPCAG00000015092 I 0.769
GLI3 Pan troglodytes ENSPTRG00000019117 I 0.769
ENSPANG00000014545 Papio anubis ENSPANG00000014545 I 0.769
ENSPPYG00000017613 Pongo abelii ENSPPYG00000017613 I 0.769
GLI3 Tursiops truncatus ENSTTRG00000003628 I 0.769
Gfo_R007869 Geospiza fortis Gfo_R007869 I 0.769
ENSP00000379258 Macaca fascicularis ENSP00000379258 I 0.769
Pvit_19093 Pogona vitticeps Pvit_19093 I 0.769
gli3.L Xenopus laevis XB-GENE-865509 I 0.769
XP_002933450 Xenopus tropicalis XP_002933450 I 0.769
XP_002933449 Xenopus tropicalis XP_002933449 I 0.769
Cmyd_10007839 Chelonia mydas Cmyd_10007839 I 0.769
Brh_R008256 Buceros rhinoceros Brh_R008256 I 0.769
GLI3 Tupaia belangeri ENSTBEG00000006673 I 0.769
ENSSHAG00000009727 Sarcophilus harrisii ENSSHAG00000009727 I 0.769
ENSTSYG00000009406 Tarsius syrichta ENSTSYG00000009406 I 0.769
Aan_R014715 Calypte anna Aan_R014715 I 0.769
Afo_R007816 Aptenodytes forsteri Afo_R007816 I 0.769
GLI3 Pteropus vampyrus ENSPVAG00000015920 I 0.769
GLI3 Otolemur garnettii ENSOGAG00000012651 I 0.769
GLI3 Felis catus ENSFCAG00000011989 I 0.769
ENSFALG00000005113 Ficedula albicollis ENSFALG00000005113 I 0.769
GLI3 Equus caballus ENSECAG00000009281 I 0.769
GLI3 Homo sapiens ENSG00000106571 D 0.769
ENSGALG00000012329 Gallus gallus ENSGALG00000012329 I 0.769
ENSMEUG00000013134 Macropus eugenii ENSMEUG00000013134 I 0.769
GLI3 Loxodonta africana ENSLAFG00000008944 I 0.769
ENSLACG00000017364 Latimeria chalumnae ENSLACG00000017364 I 0.769
GLI3 Dasypus novemcinctus ENSDNOG00000049286 I 0.769
ENSCSAG00000015361 Chlorocebus sabaeus ENSCSAG00000015361 I 0.769
ENSAMXG00000002477 Astyanax mexicanus ENSAMXG00000002477 I 0.769
ENSAMEG00000008405 Ailuropoda melanoleuca ENSAMEG00000008405 I 0.769
GLI3 Anolis carolinensis ENSACAG00000017547 I 0.769
ENSAPLG00000004361 Anas platyrhynchos ENSAPLG00000004361 I 0.769
GLI3 Bos taurus ENSBTAG00000010671 I 0.769
GLI3 Callithrix jacchus ENSCJAG00000007690 I 0.769
GLI3 Choloepus hoffmanni ENSCHOG00000003774 I 0.769
GLI3 Canis familiaris ENSCAFG00000003535 I 0.769
GLI3 Meleagris gallopavo ENSMGAG00000012277 I 0.769
GLI3 Gorilla gorilla ENSGGOG00000002026 I 0.769
ENSOARG00000017420 Ovis aries ENSOARG00000017420 I 0.769
GLI3 Macaca mulatta ENSMMUG00000013614 I 0.769
ENSNLEG00000003160 Nomascus leucogenys ENSNLEG00000003160 I 0.769
GLI3 Monodelphis domestica ENSMODG00000002714 I 0.769
ENSMPUG00000018143 Mustela putorius furo ENSMPUG00000018143 I 0.769
GLI3 Ornithorhynchus anatinus ENSOANG00000010699 I 0.769
GLI3 Oryctolagus cuniculus ENSOCUG00000006563 I 0.769
GLI3 Myotis lucifugus ENSMLUG00000015711 I 0.769
gli2b Tetraodon nigroviridis ENSTNIG00000017828 I 0.767
Pvit_05813 Pogona vitticeps Pvit_05813 I 0.767
GLI1 Anolis carolinensis ENSACAG00000006541 I 0.767
ENSAPLG00000005128 Anas platyrhynchos ENSAPLG00000005128 I 0.765
Tal_R009020 Tyto alba Tal_R009020 I 0.765
GLI2 Monodelphis domestica ENSMODG00000000245 I 0.765
gli2b Tetraodon nigroviridis ENSTNIG00000010251 I 0.765
ENSSHAG00000004233 Sarcophilus harrisii ENSSHAG00000004233 I 0.765
Gfo_R013682 Geospiza fortis Gfo_R013682 I 0.765
ENSLOCG00000005938 Lepisosteus oculatus ENSLOCG00000005938 I 0.764
ENSAMXG00000017236 Astyanax mexicanus ENSAMXG00000017236 I 0.764
ENSPANG00000024168 Papio anubis ENSPANG00000024168 I 0.763
GLI2 Canis familiaris ENSCAFG00000004821 I 0.763
Myotis_brandtii_Gli2_10019076 Myotis brandtii Myotis_brandtii_Gli2_10019076 I 0.763
ENSOARG00000013052 Ovis aries ENSOARG00000013052 I 0.763
GLI2 Oryctolagus cuniculus ENSOCUG00000000638 I 0.763
ENSAMEG00000008708 Ailuropoda melanoleuca ENSAMEG00000008708 I 0.763
ENSP00000390436-D1 Bos grunniens ENSP00000390436-D1 I 0.763
GLI2 Bos taurus ENSBTAG00000011682 I 0.763
ENSCSAG00000016668 Chlorocebus sabaeus ENSCSAG00000016668 I 0.763
GLI2 Homo sapiens ENSG00000074047 D 0.763
GLI2 Felis catus ENSFCAG00000014531 I 0.763
GLI2 Pan troglodytes ENSPTRG00000012413 I 0.763
ENSSTOG00000004582 Ictidomys tridecemlineatus ENSSTOG00000004582 I 0.763
GLI2 Macaca mulatta ENSMMUG00000001868 I 0.763
GLI2 Sus scrofa ENSSSCG00000015733 I 0.763
ENSMPUG00000000986 Mustela putorius furo ENSMPUG00000000986 I 0.763
ENSPPYG00000012778 Pongo abelii ENSPPYG00000012778 I 0.763
Gli2 Mus musculus ENSMUSG00000048402 D 0.763
ENSNLEG00000000944 Nomascus leucogenys ENSNLEG00000000944 I 0.763
ENSCJAG00000013342 Callithrix jacchus ENSCJAG00000013342 I 0.763
ENSMMUP00000002494 Macaca fascicularis ENSMMUP00000002494 I 0.763
Gli2 Rattus norvegicus ENSRNOG00000007261 I 0.763
GLI2 Cavia porcellus ENSCPOG00000015189 I 0.763
GLI2 Dasypus novemcinctus ENSDNOG00000008730 I 0.763
GLI2 Procavia capensis ENSPCAG00000001704 I 0.760
GLI2 Gorilla gorilla ENSGGOG00000009653 I 0.759
ENSLOCG00000011983 Lepisosteus oculatus ENSLOCG00000011983 I 0.759
GLI2 Otolemur garnettii ENSOGAG00000032438 I 0.757