Mbd3 (Mus musculus)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01429 (MBD) IPR001739 ENSMUSG00000035478 T260279_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000089948 MBD 1 72
ENSMUSP00000089948 MBD 75 146
ENSMUSP00000100984 MBD 12 48
ENSMUSP00000100984 MBD 49 122
ENSMUSP00000100985 MBD 4 40
ENSMUSP00000100985 MBD 76 142
ENSMUSP00000100986 MBD 4 40
ENSMUSP00000100986 MBD 44 114

Links

Other MBD family TFs
Other Mus musculus TFs

72 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Mbd3 Rattus norvegicus ENSRNOG00000028956 N 1.000
MBD3 Tursiops truncatus ENSTTRG00000004412 N 0.983
ENSPPYG00000009325 Pongo abelii ENSPPYG00000009325 I 0.977
MBD3 Homo sapiens ENSG00000071655 N 0.977
ENSPANG00000015324 Papio anubis ENSPANG00000015324 N 0.977
MBD3 Equus caballus ENSECAG00000015485 I 0.964
MBD3 Canis familiaris ENSCAFG00000019503 N 0.955
ENSAMEG00000003491 Ailuropoda melanoleuca ENSAMEG00000003491 I 0.949
ENSP00000156825 Macaca fascicularis ENSP00000156825 N 0.932
MBD3 Ochotona princeps ENSOPRG00000008719 I 0.929
ENSOARG00000012359 Ovis aries ENSOARG00000012359 I 0.924
ENSMPUG00000008045 Mustela putorius furo ENSMPUG00000008045 N 0.921
MBD3 Felis catus ENSFCAG00000000763 I 0.914
ENSAMXG00000017952 Astyanax mexicanus ENSAMXG00000017952 I 0.909
Myotis_brandtii_MBD3_10015627 Myotis brandtii Myotis_brandtii_MBD3_10015627 N 0.901
mbd3a Danio rerio ENSDARG00000061774 I 0.896
mbd3b Danio rerio ENSDARG00000042029 I 0.883
mbd3 Xenopus tropicalis XB-GENE-491553 I 0.883
MBD3 Gasterosteus aculeatus ENSGACG00000012755 I 0.880
MBD3 Pteropus vampyrus ENSPVAG00000017085 I 0.869
mbd3.S Xenopus laevis XB-GENE-491557 I 0.866
Brh_R003386 Buceros rhinoceros Brh_R003386 N 0.854
Afo_R010057 Aptenodytes forsteri Afo_R010057 N 0.854
MBD3 Tetraodon nigroviridis ENSTNIG00000010627 N 0.854
Tal_R008196 Tyto alba Tal_R008196 N 0.854
ENSGMOG00000008953 Gadus morhua ENSGMOG00000008953 I 0.847
ENSXMAG00000012716 Xiphophorus maculatus ENSXMAG00000012716 I 0.845
ENSSHAG00000013346 Sarcophilus harrisii ENSSHAG00000013346 N 0.843
ENSAPLG00000003384 Anas platyrhynchos ENSAPLG00000003384 N 0.843
MBD3 Monodelphis domestica ENSMODG00000004125 N 0.843
MBD3 Meleagris gallopavo ENSMGAG00000002493 N 0.831
Gfo_R007597 Geospiza fortis Gfo_R007597 N 0.815
Aan_R011698 Calypte anna Aan_R011698 N 0.815
MBD3 Dasypus novemcinctus ENSDNOG00000031786 N 0.795
ENSLOCG00000006043 Lepisosteus oculatus ENSLOCG00000006043 N 0.787
ENSBTAP00000003926-D1 Bos grunniens ENSBTAP00000003926-D1 N 0.780
MBD3 Sus scrofa ENSSSCG00000013435 N 0.775
ENSLACG00000016038 Latimeria chalumnae ENSLACG00000016038 I 0.775
ENSP00000256429 Macaca fascicularis ENSP00000256429 I 0.764
Pvit_04402 Pogona vitticeps Pvit_04402 I 0.764
ENSFCAG00000022047 Felis catus ENSFCAG00000022047 I 0.764
ENSP00000256429-D1 Bos grunniens ENSP00000256429-D1 I 0.764
MBD2 Microcebus murinus ENSMICG00000008970 I 0.764
ENSOARG00000004770 Ovis aries ENSOARG00000004770 I 0.764
Alligator_sinensis_CCG000430.1 Alligator sinensis Alligator_sinensis_CCG000430.1 N 0.763
Pvit_09821 Pogona vitticeps Pvit_09821 N 0.752
mbd2.S Xenopus laevis XB-GENE-493780 I 0.746
ENSLOCG00000003370 Lepisosteus oculatus ENSLOCG00000003370 I 0.742
ENSONIG00000012635 Oreochromis niloticus ENSONIG00000012635 I 0.742
ENSAMEG00000017208 Ailuropoda melanoleuca ENSAMEG00000017208 I 0.739
ENSPANG00000021858 Papio anubis ENSPANG00000021858 I 0.739
MBD2 Oryctolagus cuniculus ENSOCUG00000021080 I 0.739
MBD2 Gorilla gorilla ENSGGOG00000013402 I 0.739
Mbd2 Mus musculus ENSMUSG00000024513 D 0.739
MBD2 Monodelphis domestica ENSMODG00000011041 I 0.739
ENSMMUG00000003136 Macaca mulatta ENSMMUG00000003136 I 0.739
MBD2 Loxodonta africana ENSLAFG00000014135 I 0.739
MBD2 Homo sapiens ENSG00000134046 D 0.739
MBD2 Dasypus novemcinctus ENSDNOG00000033421 I 0.739
ENSSTOG00000011253 Ictidomys tridecemlineatus ENSSTOG00000011253 I 0.739
MBD2 Pan troglodytes ENSPTRG00000010033 I 0.739
ENSTSYG00000013361 Tarsius syrichta ENSTSYG00000013361 I 0.736
MBD3 Ornithorhynchus anatinus ENSOANG00000003672 N 0.735
Afo_R000663 Aptenodytes forsteri Afo_R000663 I 0.731
Mbd2 Rattus norvegicus ENSRNOG00000011853 I 0.730
mbd2 Danio rerio ENSDARG00000075952 I 0.725
ENSLACG00000016498 Latimeria chalumnae ENSLACG00000016498 N 0.721
MBD2 Otolemur garnettii ENSOGAG00000008028 I 0.721
ENSMEUG00000016480 Macropus eugenii ENSMEUG00000016480 I 0.717
ENSAPLG00000010058 Anas platyrhynchos ENSAPLG00000010058 I 0.708
ENSPFOG00000003939 Poecilia formosa ENSPFOG00000003939 I 0.702