nDi.2.2.2.g01429 (Dirofilaria immitis)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF03165 (MH1) IPR003619 nDi.2.2.2.g01429 T325827_2.00 WormBase:ParaSite (2015-Oct-22)

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Med
M06447_2.00 		Drosophila melanogaster
KCGBCDKKSHVT
ABDSMMHGVCGM		 B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655 		0.784 0.784
Med
M09693_2.00 		Drosophila melanogaster
YYBYVYCTGYY
RRCAGRBRVRR		 Misc
Kulakovskiy et al.(2009)
Med 		0.784 0.784
Smad4
M05889_2.00 		Mus musculus
KCYAGACR
YGTCTRGM		 SMiLE-seq
Isakova et al.(2017)
Smad4 		0.775 0.775
SMAD4
M09377_2.00 		Homo sapiens
DRGTGNSAGACWN
NWGTCTSNCACYH		 Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B 		0.775 0.775
Smad4
M09382_2.00 		Mus musculus
DGWGNBAGVCWN
NWGBCTVNCWCH		 Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A 		0.775 0.775
SMAD4
M09634_2.00 		Homo sapiens
NNNYGTCTGS
SCAGACRNNN		 Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422 		0.775 0.775
SMAD4
M11275_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q4 		0.775 0.775
SMAD4
M11276_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q6_01 		0.775 0.775
SMAD4
M11277_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q6 		0.775 0.775
sma-4
M02484_2.00 		Caenorhabditis elegans
NNCCAGACANN
NNTGTCTGGNN		 PBM
Weirauch et al.(2014)
pTH8996 		0.725 0.725
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
nDi.2.2.2.t01429 SMAD 104 205

Links

Other SMAD family TFs
Other Dirofilaria immitis TFs

253 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
WBGene00241622 Onchocerca volvulus WBGene00241622 I 0.980
nAv.1.0.1.g00430 Acanthocheilonema viteae nAv.1.0.1.g00430 I 0.980
nOo.2.0.1.g00181 Onchocerca ochengi nOo.2.0.1.g00181 I 0.980
EEL_0000707501 Elaeophora elaphi EEL_0000707501 I 0.980
nLs.2.1.2.g01457 Litomosoides sigmodontis nLs.2.1.2.g01457 I 0.971
BTMF_0000404601 Brugia timori BTMF_0000404601 I 0.971
Bm3575 Brugia malayi Bm3575 I 0.971
OFLC_0001382401 Onchocerca flexuosa OFLC_0001382401 I 0.968
WUBG_02880 Wuchereria bancrofti WUBG_02880 I 0.961
LOAG_08923 Loa loa LOAG_08923 I 0.951
GPUH_0001329001 Gongylonema pulchrum GPUH_0001329001 I 0.951
ASIM_0001604001 Anisakis simplex ASIM_0001604001 I 0.941
ASU_13433 Ascaris suum ASU_13433 I 0.931
TCLT_0000917301 Thelazia callipaeda TCLT_0000917301 I 0.892
AMEC018109 Anopheles melas AMEC018109 I 0.870
SMAD4 Sorex araneus ENSSARG00000013883 I 0.870
CGI_10018464 Crassostrea gigas CGI_10018464 I 0.857
EVEC_0000355201 Enterobius vermicularis EVEC_0000355201 I 0.848
EFV62078 Trichinella spiralis EFV62078 I 0.833
D917_09719 Trichinella nativa D917_09719 I 0.833
TMUE_s0006012700 Trichuris muris TMUE_s0006012700 I 0.824
TTRE_0000855901 Trichuris trichiura TTRE_0000855901 I 0.814
ACEP19585 Atta cephalotes ACEP19585 I 0.809
AATE010695 Anopheles atroparvus AATE010695 I 0.804
AARA004719 Anopheles arabiensis AARA004719 I 0.804
ACHR000067 Anopheles christyi ACHR000067 I 0.804
ADIR002761 Anopheles dirus ADIR002761 I 0.804
AFUN009864 Anopheles funestus AFUN009864 I 0.804
AFAF011208 Anopheles farauti AFAF011208 I 0.804
AEPI002385 Anopheles epiroticus AEPI002385 I 0.804
ACUA025512 Anopheles culicifacies ACUA025512 I 0.804
GB50071 Apis mellifera GB50071 I 0.804
KGM_12572 Danaus plexippus KGM_12572 I 0.804
Cflo_07183--XP_392838.3_APIME Camponotus floridanus Cflo_07183--XP_392838.3_APIME I 0.804
MCINX014520 Melitaea cinxia MCINX014520 I 0.804
Hsal_09633--XP_392838.3_APIME Harpegnathos saltator Hsal_09633--XP_392838.3_APIME I 0.804
CpipJ_CPIJ002563 Culex pipiens CpipJ_CPIJ002563 I 0.804
SINV15516 Solenopsis invicta SINV15516 I 0.804
HMEL002203 Heliconius melpomene HMEL002203 I 0.804
NV12984 Nasonia vitripennis NV12984 I 0.804
AMAM019778 Anopheles maculatus AMAM019778 I 0.804
ACOM037505 Anopheles coluzzii ACOM037505 I 0.804
BGIBMGA010110 Bombyx mori BGIBMGA010110 I 0.804
CPIJ002563 Culex quinquefasciatus CPIJ002563 I 0.804
DAPPUDRAFT_304115 Daphnia pulex DAPPUDRAFT_304115 I 0.804
AMEM015931 Anopheles merus AMEM015931 I 0.804
AGAP002902 Anopheles gambiae AGAP002902 I 0.804
AQUA009305 Anopheles quadriannulatus AQUA009305 I 0.804
ASTEI00079 Anopheles stephensi ASTEI00079 I 0.804
AMIN000723 Anopheles minimus AMIN000723 I 0.804
OESDEN_03018 Oesophagostomum dentatum OESDEN_03018 I 0.794
CapteG179368 Capitella teleta CapteG179368 I 0.794
SMAR013850 Strigamia maritima SMAR013850 I 0.794
RPRC010188 Rhodnius prolixus RPRC010188 I 0.794
L798_13939 Zootermopsis nevadensis L798_13939 I 0.794
ACYPI000365 Acyrthosiphon pisum ACYPI000365 I 0.794
ENSPMAG00000008404 Petromyzon marinus ENSPMAG00000008404 I 0.794
AAEL013896 Aedes aegypti AAEL013896 I 0.794
TELCIR_19676 Teladorsagia circumcincta TELCIR_19676 I 0.794
ISCW018468 Ixodes scapularis ISCW018468 I 0.794
TC010848 Tribolium castaneum TC010848 I 0.794
ADAC007516 Anopheles darlingi ADAC007516 I 0.794
SVUK_0000938201 Strongylus vulgaris SVUK_0000938201 I 0.794
PHUM002670 Pediculus humanus PHUM002670 I 0.794
LDEC015949 Leptinotarsa decemlineata LDEC015949 I 0.794
LLOJ008806 Lutzomyia longipalpis LLOJ008806 I 0.794
AALB009485 Anopheles albimanus AALB009485 I 0.794
ANCCAN_20978 Ancylostoma caninum ANCCAN_20978 I 0.794
PPAI002168 Phlebotomus papatasi PPAI002168 I 0.794
HHAL000394-PA Halyomorpha halys HHAL000394-PA I 0.794
HHAL000393-PA Halyomorpha halys HHAL000393-PA I 0.794
CLEC002594 Cimex lectularius CLEC002594 I 0.794
YQE_08737 Dendroctonus ponderosae YQE_08737 I 0.794
YQE_06624 Dendroctonus ponderosae YQE_06624 I 0.794
GI23400 Drosophila mojavensis FBgn0146126 I 0.784
GH18642 Drosophila grimshawi FBgn0126109 I 0.784
GG11819 Drosophila erecta FBgn0104114 I 0.784
GF22974 Drosophila ananassae FBgn0099968 I 0.784
Med Drosophila melanogaster FBgn0011655 D 0.784
gb:cr929477 Takifugu rubripes ENSTRUG00000011769 I 0.784
SMAD4 Takifugu rubripes ENSTRUG00000014045 I 0.784
ENSXMAG00000005051 Xiphophorus maculatus ENSXMAG00000005051 I 0.784
GL23637 Drosophila persimilis FBgn0161227 I 0.784
GA14643 Drosophila pseudoobscura FBgn0074670 I 0.784
MDOA012885 Musca domestica MDOA012885 I 0.784
LCUP007928 Lucilia cuprina LCUP007928 I 0.784
LotgiG131078 Lottia gigantea LotgiG131078 I 0.784
Ocbimv22032358m.g Octopus bimaculoides Ocbimv22032358m.g I 0.784
HCOI00676200 Haemonchus contortus HCOI00676200 I 0.784
HelroG88197 Helobdella robusta HelroG88197 I 0.784
SPU_004287 Strongylocentrotus purpuratus SPU_004287 I 0.784
SMAD4 Tetraodon nigroviridis ENSTNIG00000009050 I 0.784
GJ23092 Drosophila virilis FBgn0210194 I 0.784
GK11724 Drosophila willistoni FBgn0213735 I 0.784
GE10952 Drosophila yakuba FBgn0228782 I 0.784
GM16436 Drosophila sechellia FBgn0171351 I 0.784
ML02191a Mnemiopsis leidyi ML02191a I 0.784
ENSPFOG00000019807 Poecilia formosa ENSPFOG00000019807 I 0.784
SMAD4 Danio rerio ENSDARG00000012649 I 0.784
SMAD4 Oryzias latipes ENSORLG00000007703 I 0.784
ENSGACG00000016858 Gasterosteus aculeatus ENSGACG00000016858 I 0.784
ENSPMAG00000009414 Petromyzon marinus ENSPMAG00000009414 I 0.784
ENSONIG00000014036 Oreochromis niloticus ENSONIG00000014036 I 0.784
gb:cr929477 Tetraodon nigroviridis ENSTNIG00000003193 I 0.784
ANCCEY_04158 Ancylostoma ceylanicum ANCCEY_04158 N 0.783
SMAD4 Gorilla gorilla ENSGGOG00000013662 I 0.775
ENSGMOG00000000297 Gadus morhua ENSGMOG00000000297 I 0.775
ENSGMOG00000005844 Gadus morhua ENSGMOG00000005844 I 0.775
maker-nMf.1.1.scaf02670-augustus-gene-0.3 Meloidogyne floridensis maker-nMf.1.1.scaf02670-augustus-gene-0.3 I 0.775
smad4a Gasterosteus aculeatus ENSGACG00000007495 I 0.775
Minc05381 Meloidogyne incognita Minc05381 I 0.775
smad4.1.L Xenopus laevis XB-GENE-865543 I 0.775
smad4.1 Xenopus tropicalis XB-GENE-485691 I 0.775
AAH84196 Xenopus laevis AAH84196 I 0.775
e_gw.452.68.1 Branchiostoma floridae e_gw.452.68.1 I 0.775
Gfo_R011803 Geospiza fortis Gfo_R011803 I 0.775
ENSP00000381452 Macaca fascicularis ENSP00000381452 I 0.775
ENSP00000341551-D1 Bos grunniens ENSP00000341551-D1 I 0.775
Cmyd_10005540 Chelonia mydas Cmyd_10005540 I 0.775
Gfo_R016223 Geospiza fortis Gfo_R016223 I 0.775
Myotis_brandtii_Smad4_10005924 Myotis brandtii Myotis_brandtii_Smad4_10005924 I 0.775
Minc06628 Meloidogyne incognita Minc06628 I 0.775
Pvit_01119 Pogona vitticeps Pvit_01119 I 0.775
Ogr14199 Ophisaurus gracilis Ogr14199 I 0.775
ENSGMOG00000013964 Gadus morhua ENSGMOG00000013964 I 0.775
SMAD4 Homo sapiens ENSG00000141646 D 0.775
SMAD4 Callithrix jacchus ENSCJAG00000001910 I 0.775
ENSAMEG00000002899 Ailuropoda melanoleuca ENSAMEG00000002899 I 0.775
SMAD4 Cavia porcellus ENSCPOG00000006470 I 0.775
SMAD4 Anolis carolinensis ENSACAG00000010186 I 0.775
BGLB014287 Biomphalaria glabrata BGLB014287 I 0.775
SMAD4 Choloepus hoffmanni ENSCHOG00000000860 I 0.775
ENSAPLG00000003924 Anas platyrhynchos ENSAPLG00000003924 I 0.775
SMAD4 Bos taurus ENSBTAG00000006919 I 0.775
SMAD4 Canis familiaris ENSCAFG00000000164 I 0.775
ENSCSAG00000018094 Chlorocebus sabaeus ENSCSAG00000018094 I 0.775
genemark-nMf.1.1.scaf08549-processed-gene-0.3 Meloidogyne floridensis genemark-nMf.1.1.scaf08549-processed-gene-0.3 N 0.775
SMAD4 Echinops telfairi ENSETEG00000007750 I 0.775
SMAD4 Felis catus ENSFCAG00000005257 I 0.775
ENSAMXG00000019219 Astyanax mexicanus ENSAMXG00000019219 I 0.775
SMAD4 Loxodonta africana ENSLAFG00000012595 I 0.775
SMAD4 Equus caballus ENSECAG00000017857 I 0.775
si:dkey-239n17.4 Danio rerio ENSDARG00000070428 I 0.775
smad4a Danio rerio ENSDARG00000075226 I 0.775
SMAD4 Dasypus novemcinctus ENSDNOG00000005063 I 0.775
XP_002161797.1 Hydra magnipapillata XP_002161797.1 I 0.775
Minc15475 Meloidogyne incognita Minc15475 N 0.775
SMAD4 Ochotona princeps ENSOPRG00000013601 I 0.775
smad4a Oryzias latipes ENSORLG00000005020 I 0.775
ENSPANG00000024703 Papio anubis ENSPANG00000024703 I 0.775
ENSPFOG00000018987 Poecilia formosa ENSPFOG00000018987 I 0.775
ENSONIG00000015035 Oreochromis niloticus ENSONIG00000015035 I 0.775
ENSONIG00000010360 Oreochromis niloticus ENSONIG00000010360 I 0.775
NEMVEDRAFT_v1g248037 Nematostella vectensis NEMVEDRAFT_v1g248037 I 0.775
SMAD4 Oryctolagus cuniculus ENSOCUG00000003929 I 0.775
SMAD4 Otolemur garnettii ENSOGAG00000012081 I 0.775
ENSPPYG00000009165 Pongo abelii ENSPPYG00000009165 I 0.775
ENSPSIG00000014614 Pelodiscus sinensis ENSPSIG00000014614 I 0.775
ENSXMAG00000015245 Xiphophorus maculatus ENSXMAG00000015245 I 0.775
SMAD4 Tupaia belangeri ENSTBEG00000014105 I 0.775
SMAD4 Vicugna pacos ENSVPAG00000006757 I 0.775
ENSTSYG00000009792 Tarsius syrichta ENSTSYG00000009792 I 0.775
ENSSTOG00000028580 Ictidomys tridecemlineatus ENSSTOG00000028580 I 0.775
Brh_R010414 Buceros rhinoceros Brh_R010414 I 0.775
SMAD4 Pan troglodytes ENSPTRG00000010028 I 0.775
Smad4 Rattus norvegicus ENSRNOG00000051965 I 0.775
ENSSHAG00000010344 Sarcophilus harrisii ENSSHAG00000010344 I 0.775
ENSOARG00000004662 Ovis aries ENSOARG00000004662 I 0.775
SMAD4 Sus scrofa ENSSSCG00000004524 I 0.775
SMAD4 Macaca mulatta ENSMMUG00000018334 I 0.775
Alligator_sinensis_CCG008910.1 Alligator sinensis Alligator_sinensis_CCG008910.1 I 0.775
ENSNLEG00000011859 Nomascus leucogenys ENSNLEG00000011859 I 0.775
SMAD4 Monodelphis domestica ENSMODG00000010995 I 0.775
Smad4 Mus musculus ENSMUSG00000024515 D 0.775
ENSMPUG00000008776 Mustela putorius furo ENSMPUG00000008776 I 0.775
SMAD4 Ornithorhynchus anatinus ENSOANG00000008117 I 0.775
ENSOANG00000030959 Ornithorhynchus anatinus ENSOANG00000030959 I 0.775
Afo_R008709 Aptenodytes forsteri Afo_R008709 I 0.775
SMAD4 Myotis lucifugus ENSMLUG00000013944 I 0.775
HPBE_0001599301 Heligmosomoides bakeri HPBE_0001599301 I 0.774
Smad4 Dipodomys ordii ENSDORG00000009089 I 0.772
TriadG30731 Trichoplax adhaerens TriadG30731 I 0.765
ENSPFOG00000019867 Poecilia formosa ENSPFOG00000019867 I 0.765
L898_g17086 Steinernema monticolum L898_g17086 I 0.765
ENSAMXG00000018339 Astyanax mexicanus ENSAMXG00000018339 I 0.765
smad4.2.S Xenopus laevis XB-GENE-5995204 I 0.765
MhA1_Contig1148.frz3.fgene1 Meloidogyne hapla MhA1_Contig1148.frz3.fgene1 N 0.765
Ogr06720 Ophisaurus gracilis Ogr06720 I 0.765
tetur10g00400 Tetranychus urticae tetur10g00400 I 0.765
ENSONIG00000001557 Oreochromis niloticus ENSONIG00000001557 I 0.765
si:dkey-222b8.1 Takifugu rubripes ENSTRUG00000004163 I 0.765
ENSGACG00000003171 Gasterosteus aculeatus ENSGACG00000003171 I 0.765
ACYPI008450 Acyrthosiphon pisum ACYPI008450 I 0.765
ACYPI003759 Acyrthosiphon pisum ACYPI003759 I 0.765
ENSAMXG00000017275 Astyanax mexicanus ENSAMXG00000017275 I 0.765
si:dkey-222b8.1 Danio rerio ENSDARG00000045094 I 0.765
smad4.2.L Xenopus laevis XB-GENE-6256010 I 0.765
si:dkey-222b8.1 Gasterosteus aculeatus ENSGACG00000000538 I 0.765
ACYPI005550 Acyrthosiphon pisum ACYPI005550 I 0.755
L893_g344 Steinernema glaseri L893_g344 I 0.755
ENSLACG00000007810 Latimeria chalumnae ENSLACG00000007810 I 0.755
ENSCSAVG00000006480 Ciona savignyi ENSCSAVG00000006480 I 0.755
si:dkey-222b8.1 Tetraodon nigroviridis ENSTNIG00000005007 I 0.755
ENSMEUG00000001823 Macropus eugenii ENSMEUG00000001823 I 0.752
HelroG76435 Helobdella robusta HelroG76435 I 0.745
ANCCAN_20979 Ancylostoma caninum ANCCAN_20979 N 0.745
smad4 Ciona intestinalis ENSCING00000005559 I 0.745
D918_00298 Trichuris suis D918_00298 I 0.740
L898_g26477 Steinernema monticolum L898_g26477 I 0.735
L893_g15056 Steinernema glaseri L893_g15056 I 0.735
L889_g28104 Steinernema feltiae L889_g28104 I 0.735
fgenesh2_pg.scaffold_230000050 Branchiostoma floridae fgenesh2_pg.scaffold_230000050 I 0.735
Aqu1.215834 Amphimedon queenslandica Aqu1.215834 I 0.735
SMU15015494 Schmidtea mediterranea SMU15015494 I 0.735
Aqu1.215833 Amphimedon queenslandica Aqu1.215833 I 0.735
L596_g15 Steinernema carpocapsae L596_g15 I 0.735
L893_g8358 Steinernema glaseri L893_g8358 N 0.735
GPLIN_000772200 Globodera pallida GPLIN_000772200 I 0.735
nLs.2.1.2.g01829 Litomosoides sigmodontis nLs.2.1.2.g01829 I 0.733
L892_g27454 Steinernema scapterisci L892_g27454 I 0.733
ALUE_0001111401 Ascaris lumbricoides ALUE_0001111401 I 0.733
ASU_10605 Ascaris suum ASU_10605 I 0.733
sma-4 Caenorhabditis elegans WBGene00004858 D 0.733
CRE04707 Caenorhabditis remanei CRE04707 I 0.733
Bm5359 Brugia malayi Bm5359 I 0.733
WUBG_08631 Wuchereria bancrofti WUBG_08631 I 0.733
BTMF_0000952301 Brugia timori BTMF_0000952301 I 0.733
L889_g22387 Steinernema feltiae L889_g22387 I 0.733
CJA09693 Caenorhabditis japonica CJA09693 I 0.733
Alligator_sinensis_CCG001823.1 Alligator sinensis Alligator_sinensis_CCG001823.1 I 0.725
L889_g6780 Steinernema feltiae L889_g6780 I 0.725
nDi.2.2.2.g06233 Dirofilaria immitis nDi.2.2.2.g06233 I 0.723
nOo.2.0.1.g06266 Onchocerca ochengi nOo.2.0.1.g06266 I 0.723
CBG09090 Caenorhabditis briggsae CBG09090 I 0.723
nAv.1.0.1.g08553 Acanthocheilonema viteae nAv.1.0.1.g08553 I 0.723
WBGene00245700 Onchocerca volvulus WBGene00245700 I 0.723
LOAG_05337 Loa loa LOAG_05337 I 0.723
TCLT_0000412001 Thelazia callipaeda TCLT_0000412001 I 0.723
OFLC_0000505301 Onchocerca flexuosa OFLC_0000505301 I 0.723
L892_g19326 Steinernema scapterisci L892_g19326 N 0.717
BXY_0211100 Bursaphelenchus xylophilus BXY_0211100 N 0.716
ANCDUO_23180 Ancylostoma duodenale ANCDUO_23180 N 0.714
ASIM_0001219601 Anisakis simplex ASIM_0001219601 I 0.713
L596_g26024 Steinernema carpocapsae L596_g26024 I 0.713
L892_g4495 Steinernema scapterisci L892_g4495 I 0.713
CBN31444 Caenorhabditis brenneri CBN31444 I 0.713
ECANG7_08262 Echinococcus canadensis ECANG7_08262 N 0.706
RSKR_0000114900 Rhabditophanes kr3021 RSKR_0000114900 I 0.706
Bm11291 Brugia malayi Bm11291 I 0.705
ANCDUO_13021 Ancylostoma duodenale ANCDUO_13021 I 0.703
Ppa-sma-4 Pristionchus pacificus PPA17857 I 0.703
scaffold21-EXSNAP2012.60 Pristionchus exspectatus scaffold21-EXSNAP2012.60 I 0.703
EVEC_0000562301 Enterobius vermicularis EVEC_0000562301 I 0.703