ENSP00000386854 (Macaca fascicularis)
C2H2 ZF,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2)
PF00046 (Homeobox)
IPR007087
IPR001356
ENSP00000386854 T076239_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZEB2
M10096_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIP1_Q6
1.000 1.000
ZEB1
M08080_2.00
Homo sapiens
NNCACCTGBNN

NNVCAGGTGNN
ChIP-seq
Mathelier et al.(2014)
MA0103.3
0.829 0.829
ZEB1
M07842_2.00
Homo sapiens
YNCACCTG

CAGGTGNR
ChIP-seq
Gerstein et al.(2012)
GM12878_ZEB1_HudsonAlpha
0.829 0.829
ZEB1
M08190_2.00
Homo sapiens
CVCWCACCTG

CAGGTGWGBG
ChIP-seq
Contrino et al.(2012)
Mv136
0.829 0.829
ZEB1
M08848_2.00
Homo sapiens
YHYACCTGBV

BVCAGGTRDR
Misc
Kulakovskiy et al.(2013)
ZEB1_HUMAN.H11MO.0.A
0.829 0.829
ZEB1
M10089_2.00
Homo sapiens
NHYDYACCTGWVY

RBWCAGGTRHRDN
Transfac
Matys et al.(2006)
V$AREB6_01
0.829 0.829
ZEB1
M10090_2.00
Homo sapiens
WHWCACCTKWNN

NNWMAGGTGWDW
Transfac
Matys et al.(2006)
V$AREB6_02
0.829 0.829
ZEB1
M10091_2.00
Homo sapiens
VBRCACCTGKDV

BHMCAGGTGYVB
Transfac
Matys et al.(2006)
V$AREB6_03
0.829 0.829
ZEB1
M10092_2.00
Homo sapiens
NNSAAACVB

VBGTTTSNN
Transfac
Matys et al.(2006)
V$AREB6_04
0.829 0.829
ZEB1
M10093_2.00
Homo sapiens
NHNCACCTDRV

BYHAGGTGNDN
Transfac
Matys et al.(2006)
V$DELTAEF1_01
0.829 0.829
ZEB1
M10094_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZEB1_03
0.829 0.829
ZEB1
M10095_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZEB_Q3
0.829 0.829
Zeb1
M05844_2.00
Mus musculus
NYACCTGN

NCAGGTRN
SMiLE-seq
Isakova et al.(2017)
ZEB1
0.824 0.824
Zeb1
M08849_2.00
Mus musculus
YHYACCTGBV

BVCAGGTRDR
Misc
Kulakovskiy et al.(2013)
ZEB1_MOUSE.H11MO.0.B
0.824 0.824
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000386854 C2H2 ZF 208 231
ENSP00000386854 C2H2 ZF 238 260
ENSP00000386854 C2H2 ZF 279 301
ENSP00000386854 C2H2 ZF 307 328
ENSP00000386854 Homeodomain 646 696
ENSP00000386854 C2H2 ZF 996 1018
ENSP00000386854 C2H2 ZF 1024 1046
ENSP00000386854 C2H2 ZF 1052 1073

Links

Other C2H2 ZF,Homeodomain family TFs
Other Macaca fascicularis TFs

125 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Zeb2 Mus musculus ENSMUSG00000026872 I 1.000
ENSMPUG00000003620 Mustela putorius furo ENSMPUG00000003620 I 1.000
ENSNLEG00000009020 Nomascus leucogenys ENSNLEG00000009020 I 1.000
ZEB2 Oryctolagus cuniculus ENSOCUG00000027880 I 1.000
ZEB2 Otolemur garnettii ENSOGAG00000010020 I 1.000
ZEB2 Monodelphis domestica ENSMODG00000003112 I 1.000
ZEB2 Macaca mulatta ENSMMUG00000016845 I 1.000
ZEB2 Gorilla gorilla ENSGGOG00000003186 I 1.000
ENSGALG00000012440 Gallus gallus ENSGALG00000012440 I 1.000
ZEB2 Loxodonta africana ENSLAFG00000008960 I 1.000
ZEB2 Meleagris gallopavo ENSMGAG00000012628 I 1.000
ZEB2 Myotis lucifugus ENSMLUG00000002019 I 1.000
ENSPANG00000008399 Papio anubis ENSPANG00000008399 I 1.000
ENSPPYG00000012831 Pongo abelii ENSPPYG00000012831 I 1.000
Myotis_brandtii_ZEB2_10007070 Myotis brandtii Myotis_brandtii_ZEB2_10007070 I 1.000
ENSBTAP00000053646-D1 Bos grunniens ENSBTAP00000053646-D1 I 1.000
zeb2 Xenopus tropicalis XB-GENE-479558 I 1.000
XP_002936763 Xenopus tropicalis XP_002936763 I 1.000
XP_002936766 Xenopus tropicalis XP_002936766 I 1.000
Alligator_sinensis_CCG017701.1 Alligator sinensis Alligator_sinensis_CCG017701.1 I 1.000
ZEB2 Vicugna pacos ENSVPAG00000002128 I 1.000
Zeb2 Rattus norvegicus ENSRNOG00000004677 I 1.000
ZEB2 Pan troglodytes ENSPTRG00000012513 I 1.000
ENSSHAG00000016692 Sarcophilus harrisii ENSSHAG00000016692 I 1.000
ENSSTOG00000003811 Ictidomys tridecemlineatus ENSSTOG00000003811 I 1.000
ZEB2 Tursiops truncatus ENSTTRG00000006478 I 1.000
ZEB2 Homo sapiens ENSG00000169554 D 1.000
ZEB2 Ochotona princeps ENSOPRG00000006205 I 1.000
ZEB2 Cavia porcellus ENSCPOG00000004182 I 1.000
ENSCSAG00000016197 Chlorocebus sabaeus ENSCSAG00000016197 I 1.000
ZEB2 Dasypus novemcinctus ENSDNOG00000039558 I 1.000
ZEB2 Choloepus hoffmanni ENSCHOG00000001435 I 1.000
ZEB2 Canis familiaris ENSCAFG00000005497 I 1.000
ENSAMEG00000009337 Ailuropoda melanoleuca ENSAMEG00000009337 I 1.000
ENSAPLG00000007687 Anas platyrhynchos ENSAPLG00000007687 I 1.000
ZEB2 Bos taurus ENSBTAG00000012615 I 1.000
ZEB2 Equus caballus ENSECAG00000019355 I 1.000
ZEB2 Callithrix jacchus ENSCJAG00000012457 I 1.000
ZEB2 Felis catus ENSFCAG00000015532 I 1.000
Afo_R000542 Aptenodytes forsteri Afo_R000542 I 0.995
Aan_R003058 Calypte anna Aan_R003058 I 0.995
ZEB2 Taeniopygia guttata ENSTGUG00000011904 I 0.995
ENSFALG00000013846 Ficedula albicollis ENSFALG00000013846 I 0.995
Gfo_R001123 Geospiza fortis Gfo_R001123 I 0.995
Brh_R003547 Buceros rhinoceros Brh_R003547 I 0.995
ENSPSIG00000016788 Pelodiscus sinensis ENSPSIG00000016788 I 0.990
zeb2.S Xenopus laevis XB-GENE-865280 I 0.990
Cmyd_10013008 Chelonia mydas Cmyd_10013008 I 0.990
Pvit_13221 Pogona vitticeps Pvit_13221 I 0.981
Ogr14261 Ophisaurus gracilis Ogr14261 I 0.981
ZEB2 Anolis carolinensis ENSACAG00000023811 I 0.981
ENSGMOG00000010266 Gadus morhua ENSGMOG00000010266 I 0.909
ENSXMAG00000002123 Xiphophorus maculatus ENSXMAG00000002123 I 0.854
ENSPFOG00000016296 Poecilia formosa ENSPFOG00000016296 I 0.847
ENSLACG00000013253 Latimeria chalumnae ENSLACG00000013253 I 0.841
ZEB1 Pan troglodytes ENSPTRG00000002404 I 0.837
ZEB1 Homo sapiens ENSG00000148516 D 0.837
ENSPPYG00000002189 Pongo abelii ENSPPYG00000002189 I 0.837
ZEB1 Pteropus vampyrus ENSPVAG00000010088 I 0.837
ENSPSIG00000009469 Pelodiscus sinensis ENSPSIG00000009469 I 0.837
ENSSHAG00000005352 Sarcophilus harrisii ENSSHAG00000005352 I 0.837
Cmyd_10008652 Chelonia mydas Cmyd_10008652 I 0.837
ZEB1 Bos taurus ENSBTAG00000020053 I 0.837
Alligator_sinensis_CCG010397.1 Alligator sinensis Alligator_sinensis_CCG010397.1 I 0.837
ENSSTOG00000016404 Ictidomys tridecemlineatus ENSSTOG00000016404 I 0.837
ENSP00000319248 Macaca fascicularis ENSP00000319248 I 0.837
ZEB1 Canis familiaris ENSCAFG00000004023 I 0.837
ZEB1 Felis catus ENSFCAG00000010440 I 0.837
ZEB1 Callithrix jacchus ENSCJAG00000013332 I 0.837
ZEB1 Gorilla gorilla ENSGGOG00000010090 I 0.837
ENSCSAG00000011628 Chlorocebus sabaeus ENSCSAG00000011628 I 0.837
ENSMPUG00000013033 Mustela putorius furo ENSMPUG00000013033 I 0.837
ZEB1 Dasypus novemcinctus ENSDNOG00000016748 I 0.837
Zeb1 Dipodomys ordii ENSDORG00000007230 I 0.837
ZEB1 Macaca mulatta ENSMMUG00000015453 I 0.837
ZEB1 Otolemur garnettii ENSOGAG00000008365 I 0.837
ENSNLEG00000018130 Nomascus leucogenys ENSNLEG00000018130 I 0.837
ENSAMEG00000010224 Ailuropoda melanoleuca ENSAMEG00000010224 I 0.837
ENSPANG00000022899 Papio anubis ENSPANG00000022899 I 0.837
ENSLOCG00000007239 Lepisosteus oculatus ENSLOCG00000007239 I 0.836
ZEB1 Loxodonta africana ENSLAFG00000009663 I 0.836
zeb1b Danio rerio ENSDARG00000013207 I 0.835
ZEB1 Monodelphis domestica ENSMODG00000007847 I 0.833
Aan_R013683 Calypte anna Aan_R013683 I 0.832
ENSAPLG00000007482 Anas platyrhynchos ENSAPLG00000007482 I 0.832
Tal_R009077 Tyto alba Tal_R009077 I 0.832
ZEB1 Gallus gallus ENSGALG00000007260 I 0.832
Afo_R009258 Aptenodytes forsteri Afo_R009258 I 0.832
ZEB1 Anolis carolinensis ENSACAG00000007353 I 0.832
Zeb1 Rattus norvegicus ENSRNOG00000017863 I 0.832
ZEB1 Meleagris gallopavo ENSMGAG00000006355 I 0.831
zeb1 Xenopus tropicalis XB-GENE-484655 I 0.830
Myotis_brandtii_ZEB1_10033015 Myotis brandtii Myotis_brandtii_ZEB1_10033015 I 0.829
ZEB1 Sorex araneus ENSSARG00000010985 I 0.829
Gfo_R014876 Geospiza fortis Gfo_R014876 I 0.827
ENSFALG00000007118 Ficedula albicollis ENSFALG00000007118 I 0.827
Zeb1 Mus musculus ENSMUSG00000024238 D 0.824
ENSONIG00000003766 Oreochromis niloticus ENSONIG00000003766 I 0.823
ZEB1 Taeniopygia guttata ENSTGUG00000001020 I 0.822
zeb1b Oryzias latipes ENSORLG00000004296 I 0.820
ABC48601 Xenopus laevis ABC48601 I 0.816
ENSXMAG00000005475 Xiphophorus maculatus ENSXMAG00000005475 I 0.811
ENSPFOG00000013823 Poecilia formosa ENSPFOG00000013823 I 0.808
zeb1.S Xenopus laevis XB-GENE-865109 I 0.805
zeb1b Gasterosteus aculeatus ENSGACG00000001002 I 0.805
ZEB2 Pteropus vampyrus ENSPVAG00000015557 I 0.795
zeb1a Tetraodon nigroviridis ENSTNIG00000007962 I 0.788
ZEB2 Sorex araneus ENSSARG00000006858 I 0.786
ENSMEUG00000008997 Macropus eugenii ENSMEUG00000008997 I 0.786
ENSOARG00000009880 Ovis aries ENSOARG00000009880 I 0.786
ZEB2 Tupaia belangeri ENSTBEG00000013983 I 0.781
Tal_R007044 Tyto alba Tal_R007044 I 0.781
ENSXMAG00000006005 Xiphophorus maculatus ENSXMAG00000006005 I 0.779
ENSPFOG00000014121 Poecilia formosa ENSPFOG00000014121 I 0.779
ENSPFOG00000014086 Poecilia formosa ENSPFOG00000014086 I 0.779
ENSONIG00000015066 Oreochromis niloticus ENSONIG00000015066 I 0.770
zeb1b Takifugu rubripes ENSTRUG00000001422 I 0.762
ENSAMXG00000010069 Astyanax mexicanus ENSAMXG00000010069 I 0.748
zeb1a Gasterosteus aculeatus ENSGACG00000017648 I 0.746
XP_002936765 Xenopus tropicalis XP_002936765 I 0.743
ENSTSYG00000009434 Tarsius syrichta ENSTSYG00000009434 I 0.743
ZEB2 Procavia capensis ENSPCAG00000014674 I 0.743
zeb1a Danio rerio ENSDARG00000016788 I 0.729
ZEB1 Cavia porcellus ENSCPOG00000007682 I 0.710
ZEB1 Myotis lucifugus ENSMLUG00000010631 I 0.710