NFKB1 (Homo sapiens)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSG00000109320 T317172_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NFKB1
M03448_2.00
Homo sapiens
MGGGGAWTCCCCT

AGGGGAWTCCCCK
SELEX
Jolma et al.(2013)
NFKB1_1
(Direct) (Direct)
NFKB1
M05887_2.00
Homo sapiens
NGGKRNTYYCCCN

NGGGRRANYMCCN
SMiLE-seq
Isakova et al.(2017)
NFKB1
(Direct) (Direct)
NFKB1
M09348_2.00
Homo sapiens
HYTTCCCY

RGGGAARD
Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A
(Direct) (Direct)
NFKB1
M11228_2.00
Homo sapiens
GGGGATYCCC

GGGRATCCCC
Transfac
Matys et al.(2006)
V$NFKAPPAB50_01
(Direct) (Direct)
NFKB1
M11229_2.00
Homo sapiens
NGGGAHTYYCCM

KGGRRADTCCCN
Transfac
Matys et al.(2006)
V$NFKB_C
(Direct) (Direct)
NFKB1
M11230_2.00
Homo sapiens
DKGGGAMTTYCCNN

NNGGRAAKTCCCMH
Transfac
Matys et al.(2006)
V$NFKB_Q6
(Direct) (Direct)
NFKB1
M11231_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P50_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Nfkb1
M09358_2.00
Mus musculus
GGGRNTTYCCC

GGGRAANYCCC
Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A
1.000 1.000
NFKB2
M03446_2.00
Homo sapiens
NGGGGAWTCCCCB

VGGGGAWTCCCCN
SELEX
Jolma et al.(2013)
NFKB2_1
0.700 0.700
NFKB2
M05699_2.00
Homo sapiens
HGGKRNWTCCCCN

NGGGGAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX
0.700 0.700
NFKB2
M09344_2.00
Homo sapiens
GGGRHTTYCCC

GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B
0.870 0.870
Nfkb2
M09356_2.00
Mus musculus
GGGRHTTYCCC

GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C
0.870 0.870
NFKB2
M05700_2.00
Homo sapiens
HGGKRNWTYCCCN

NGGGRAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX
0.700 0.700
RELB
M08161_2.00
Homo sapiens
NNATTCCCCNN

NNGGGGAATNN
ChIP-seq
Mathelier et al.(2014)
MA1117.1
0.739 0.739
RELB
M09347_2.00
Homo sapiens
VGGGRMTTTSMH

DKSAAAKYCCCB
Misc
Kulakovskiy et al.(2013)
RELB_HUMAN.H11MO.0.C
0.739 0.739
Relb
M09352_2.00
Mus musculus
VGGGRMTTTSMH

DKSAAAKYCCCB
Misc
Kulakovskiy et al.(2013)
RELB_MOUSE.H11MO.0.C
0.739 0.739
RELB
M11227_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELBP50_Q3
0.739 0.739
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000226574 Rel 45 243
ENSP00000378297 Rel 44 242
ENSP00000420904 Rel 52 74
ENSP00000423877 Rel 45 144
ENSP00000424790 Rel 44 242
ENSP00000424815 Rel 1 36
ENSP00000426147 Rel 53 186
ENSP00000469340 Rel 6 62

Links

Other Rel family TFs
Other Homo sapiens TFs

79 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
NFKB1 Loxodonta africana ENSLAFG00000009344 I 1.000
NFKB1 Tursiops truncatus ENSTTRG00000010852 I 1.000
NFKB1 Gorilla gorilla ENSGGOG00000009071 I 1.000
NFKB1 Pan troglodytes ENSPTRG00000016320 I 1.000
NFKB1 Pteropus vampyrus ENSPVAG00000002722 I 1.000
NFKB1 Sus scrofa ENSSSCG00000030957 I 1.000
NFKB1 Macaca mulatta ENSMMUG00000003736 I 1.000
ENSAMEG00000008882 Ailuropoda melanoleuca ENSAMEG00000008882 I 1.000
NFKB1 Tupaia belangeri ENSTBEG00000003520 I 1.000
ENSOARG00000012718 Ovis aries ENSOARG00000012718 I 1.000
ENSNLEG00000013325 Nomascus leucogenys ENSNLEG00000013325 I 1.000
ENSMPUG00000009413 Mustela putorius furo ENSMPUG00000009413 I 1.000
NFKB1 Vicugna pacos ENSVPAG00000000280 I 1.000
Nfkb1 Rattus norvegicus ENSRNOG00000023258 I 1.000
NFKB1 Bos taurus ENSBTAG00000020270 I 1.000
ENSCSAG00000004049 Chlorocebus sabaeus ENSCSAG00000004049 I 1.000
NFKB1 Canis familiaris ENSCAFG00000010730 I 1.000
ENSP00000226574 Macaca fascicularis ENSP00000226574 I 1.000
ENSBTAP00000027016-D1 Bos grunniens ENSBTAP00000027016-D1 I 1.000
NFKB1 Equus caballus ENSECAG00000015042 I 1.000
NFKB1 Callithrix jacchus ENSCJAG00000015382 I 0.994
ENSPPYG00000014965 Pongo abelii ENSPPYG00000014965 I 0.994
ENSSTOG00000011445 Ictidomys tridecemlineatus ENSSTOG00000011445 I 0.990
NFKB1 Otolemur garnettii ENSOGAG00000012840 I 0.990
NFKB1 Felis catus ENSFCAG00000007557 I 0.990
NFKB1 Dasypus novemcinctus ENSDNOG00000006855 I 0.988
Nfkb1 Mus musculus ENSMUSG00000028163 D 0.982
ENSSHAG00000007374 Sarcophilus harrisii ENSSHAG00000007374 I 0.980
ENSMEUG00000001334 Macropus eugenii ENSMEUG00000001334 I 0.980
NFKB1 Cavia porcellus ENSCPOG00000007789 I 0.976
Nfkb1 Dipodomys ordii ENSDORG00000007447 I 0.976
NFKB1 Oryctolagus cuniculus ENSOCUG00000021712 I 0.970
NFKB1 Ochotona princeps ENSOPRG00000005212 I 0.970
Myotis_brandtii_NFKB1_10013135 Myotis brandtii Myotis_brandtii_NFKB1_10013135 I 0.970
NFKB1 Myotis lucifugus ENSMLUG00000005986 I 0.970
NFKB1 Monodelphis domestica ENSMODG00000020672 I 0.970
NFKB1 Procavia capensis ENSPCAG00000008172 I 0.959
Tal_R004861 Tyto alba Tal_R004861 I 0.957
ENSPANG00000023882 Papio anubis ENSPANG00000023882 I 0.953
Afo_R015662 Aptenodytes forsteri Afo_R015662 I 0.940
Gfo_R000994 Geospiza fortis Gfo_R000994 I 0.940
NFKB1 Taeniopygia guttata ENSTGUG00000003595 I 0.940
ENSFALG00000008136 Ficedula albicollis ENSFALG00000008136 I 0.917
NFKB1 Meleagris gallopavo ENSMGAG00000011299 I 0.911
NFKB1 Gallus gallus ENSGALG00000012304 I 0.911
Brh_R011794 Buceros rhinoceros Brh_R011794 I 0.911
ENSAPLG00000013878 Anas platyrhynchos ENSAPLG00000013878 I 0.911
Alligator_sinensis_CCG005309.1 Alligator sinensis Alligator_sinensis_CCG005309.1 I 0.905
ENSPSIG00000008515 Pelodiscus sinensis ENSPSIG00000008515 I 0.905
Aan_R012729 Calypte anna Aan_R012729 I 0.905
Pvit_05196 Pogona vitticeps Pvit_05196 I 0.888
ENSOANG00000028755 Ornithorhynchus anatinus ENSOANG00000028755 I 0.872
ENSPMAG00000006461 Petromyzon marinus ENSPMAG00000006461 N 0.870
Ogr10707 Ophisaurus gracilis Ogr10707 I 0.846
ENSOANG00000022123 Ornithorhynchus anatinus ENSOANG00000022123 I 0.842
ENSLACG00000002751 Latimeria chalumnae ENSLACG00000002751 I 0.830
nfkb2 Oryzias latipes ENSORLG00000002942 N 0.826
ENSONIG00000007023 Oreochromis niloticus ENSONIG00000007023 N 0.826
nfkb1 Xenopus tropicalis XB-GENE-985746 I 0.811
nfkb1.L Xenopus laevis XB-GENE-985749 I 0.800
BGLB002091 Biomphalaria glabrata BGLB002091 N 0.783
nfkb1 Danio rerio ENSDARG00000105261 I 0.760
ENSLOCG00000012080 Lepisosteus oculatus ENSLOCG00000012080 I 0.751
ENSOPRG00000014981 Ochotona princeps ENSOPRG00000014981 I 0.739
ENSTNIG00000002231 Tetraodon nigroviridis ENSTNIG00000002231 N 0.739
ENSCSAVG00000003063 Ciona savignyi ENSCSAVG00000003063 N 0.722
ENSXMAG00000015369 Xiphophorus maculatus ENSXMAG00000015369 I 0.720
ENSAMXG00000003341 Astyanax mexicanus ENSAMXG00000003341 I 0.716
ENSPFOG00000016918 Poecilia formosa ENSPFOG00000016918 I 0.716
ENSONIG00000004349 Oreochromis niloticus ENSONIG00000004349 I 0.710
ENSLACG00000016308 Latimeria chalumnae ENSLACG00000016308 N 0.710
ENSGMOG00000007506 Gadus morhua ENSGMOG00000007506 N 0.710
NFKB1 Gasterosteus aculeatus ENSGACG00000016876 I 0.710
nfkb2.S Xenopus laevis XB-GENE-970090 N 0.700
NFKB2 Loxodonta africana ENSLAFG00000006805 I 0.700
NFKB2 Procavia capensis ENSPCAG00000011503 I 0.700
ENSLOCG00000012413 Lepisosteus oculatus ENSLOCG00000012413 N 0.700
NFKB2 Sorex araneus ENSSARG00000006180 I 0.700