rfx5 (Danio rerio)
RFX

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02257 (RFX_DNA_binding) IPR003150 ENSDARG00000063258 T318193_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within proteolysis and regulation of transcription, DNA-templated. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFX5 (regulatory factor X5). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RFX5
M03458_2.00 		Homo sapiens
BGTTRCYATRGYAACV
BGTTRCYATRGYAACV		 SELEX
Jolma et al.(2013)
RFX5_1 		0.739 0.759
RFX5
M03459_2.00 		Homo sapiens
BGTTGCYATGGYAACV
BGTTRCCATRGCAACV		 SELEX
Jolma et al.(2013)
RFX5_2 		0.739 0.759
RFX5
M03460_2.00 		Homo sapiens
BGTTGCYATGGYAACV
BGTTRCCATRGCAACV		 SELEX
Jolma et al.(2013)
RFX5_3 		0.739 0.759
RFX5
M05725_2.00 		Homo sapiens
BGTTRCYANGBGTTGCYRN
NYRGCAACVCNTRGYAACV		 SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_1 		0.739 0.759
RFX5
M05726_2.00 		Homo sapiens
NYRVYAACSGTTRCYAN
NTRGYAACSGTTRBYRN		 SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_2 		0.739 0.759
RFX5
M08009_2.00 		Homo sapiens
KCRBYDGTTRCYRRG
CYYRGYAACHRVYGM		 ChIP-seq
Gerstein et al.(2012)
GM12878_RFX5_Stanford 		0.739 0.759
RFX5
M08010_2.00 		Homo sapiens
DBVBYDGTTGCYRGGBVRR
YYBVCCYRGCAACHRVBVH		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_RFX5_Stanford 		0.739 0.759
RFX5
M08011_2.00 		Homo sapiens
TCVBYDGTTDCYRDG
CHYRGHAACHRVBGA		 ChIP-seq
Gerstein et al.(2012)
HeLa-S3_RFX5_Stanford 		0.739 0.759
RFX5
M08012_2.00 		Homo sapiens
YDGTTRCYRKGBVRV
BYBVCMYRGYAACHR		 ChIP-seq
Gerstein et al.(2012)
HepG2_RFX5_Stanford 		0.739 0.759
RFX5
M09364_2.00 		Homo sapiens
VNNVBYDGTTGCYRKGNVRV
BYBNCMYRGCAACHRVBNNB		 Misc
Kulakovskiy et al.(2013)
RFX5_HUMAN.H11MO.0.A 		0.739 0.759
RFX5
M09629_2.00 		Homo sapiens
NDGTTRCYADGV
BCHTRGYAACHN		 Misc
Heinz et al.(2010)
GM12878-Rfx5_GSE31477 		0.739 0.759
RFX5
M11249_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RFX5_03 		0.739 0.759
RFX5
M11250_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RFX5_05 		0.739 0.759
RFX5
M05727_2.00 		Homo sapiens
BGTYRYYRNGBGTTGYYRN
NYRRCAACVCNYRRYRACV		 SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_1 		0.739 0.759
RFX5
M05728_2.00 		Homo sapiens
NTRGYAASSGTYRBYRN
NYRVYRACSSTTRCYAN		 SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_2 		0.739 0.759
Rfx7
M00823_2.00 		Mus musculus
GTYRCYRNSB
VSNYRGYRAC		 PBM
Weirauch et al.(2013)
pTH3516 		0.716 0.646
Rfx7
M00187_2.00 		Mus musculus
BGTHDYYRNN
NNYRRHDACV		 PBM
Badis et al.(2009)
Rfxdc2_3516 		0.716 0.646
RFX7
M05729_2.00 		Homo sapiens
BGTTRCYRY
RYRGYAACV		 SELEX
Yin et al.(2017)
RFX7_eDBD_HT-SELEX 		0.716 0.646
RFX7
M05730_2.00 		Homo sapiens
BGTTGCYRB
VYRGCAACV		 SELEX
Yin et al.(2017)
RFX7_eDBD_Methyl-HT-SELEX 		0.716 0.646
For this family, TFs with SR scores > 0.650 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000086706 RFX 81 159
ENSDARP00000124450 RFX 81 159

Links

Other RFX family TFs
Other Danio rerio TFs

229 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSLOCG00000008459 Lepisosteus oculatus ENSLOCG00000008459 I 0.793
ENSAMXG00000008359 Astyanax mexicanus ENSAMXG00000008359 I 0.792
ENSPFOG00000010592 Poecilia formosa ENSPFOG00000010592 I 0.791
ENSXMAG00000017295 Xiphophorus maculatus ENSXMAG00000017295 I 0.791
ENSTRUG00000000177 Takifugu rubripes ENSTRUG00000000177 I 0.789
rfx5 Tetraodon nigroviridis ENSTNIG00000005388 I 0.789
ENSONIG00000003955 Oreochromis niloticus ENSONIG00000003955 I 0.788
ENSORLG00000001269 Oryzias latipes ENSORLG00000001269 I 0.778
rfx5 Xenopus tropicalis XB-GENE-5942579 I 0.763
RFX5 Gallus gallus ENSGALG00000000836 I 0.761
Gfo_R003263 Geospiza fortis Gfo_R003263 I 0.759
ENSFALG00000010929 Ficedula albicollis ENSFALG00000010929 I 0.759
Afo_R007667 Aptenodytes forsteri Afo_R007667 I 0.757
ENSMGAG00000001126 Meleagris gallopavo ENSMGAG00000001126 I 0.756
RFX5 Procavia capensis ENSPCAG00000011056 I 0.755
Alligator_sinensis_CCG020683.1 Alligator sinensis Alligator_sinensis_CCG020683.1 I 0.754
ENSACAG00000029645 Anolis carolinensis ENSACAG00000029645 I 0.751
Pvit_04986 Pogona vitticeps Pvit_04986 I 0.751
Myotis_brandtii_RFX5_10008035 Myotis brandtii Myotis_brandtii_RFX5_10008035 I 0.750
RFX5 Myotis lucifugus ENSMLUG00000015218 I 0.750
ENSAMEG00000000695 Ailuropoda melanoleuca ENSAMEG00000000695 I 0.750
Aan_R010941 Calypte anna Aan_R010941 I 0.749
ENSPSIG00000018073 Pelodiscus sinensis ENSPSIG00000018073 I 0.748
rfx5.S Xenopus laevis XB-GENE-6079297 I 0.748
Ogr13052 Ophisaurus gracilis Ogr13052 I 0.743
ENSSTOG00000013246 Ictidomys tridecemlineatus ENSSTOG00000013246 I 0.741
ENSMEUG00000011101 Macropus eugenii ENSMEUG00000011101 I 0.740
ENSSHAG00000014366 Sarcophilus harrisii ENSSHAG00000014366 I 0.740
ENSMPUG00000003735 Mustela putorius furo ENSMPUG00000003735 I 0.739
ENSNLEG00000010170 Nomascus leucogenys ENSNLEG00000010170 I 0.739
ENSOARG00000020987 Ovis aries ENSOARG00000020987 I 0.739
RFX5 Otolemur garnettii ENSOGAG00000008120 I 0.739
ENSMMUG00000013172 Macaca mulatta ENSMMUG00000013172 I 0.739
RFX5 Bos taurus ENSBTAG00000017580 I 0.739
RFX5 Canis familiaris ENSCAFG00000012661 I 0.739
RFX5 Gorilla gorilla ENSGGOG00000016795 I 0.739
RFX5 Loxodonta africana ENSLAFG00000030906 I 0.739
ENSPANG00000005712 Papio anubis ENSPANG00000005712 I 0.739
ENSPPYG00000000867 Pongo abelii ENSPPYG00000000867 I 0.739
ENSP00000389130 Macaca fascicularis ENSP00000389130 I 0.739
ENSP00000389130-D1 Bos grunniens ENSP00000389130-D1 I 0.739
RFX5 Tursiops truncatus ENSTTRG00000007023 I 0.739
RFX5 Tupaia belangeri ENSTBEG00000006419 I 0.739
RFX5 Sus scrofa ENSSSCG00000006625 I 0.739
RFX5 Pan troglodytes ENSPTRG00000001286 I 0.739
RFX5 Pteropus vampyrus ENSPVAG00000011680 I 0.739
RFX5 Sorex araneus ENSSARG00000000750 I 0.739
RFX5 Homo sapiens ENSG00000143390 D 0.739
ENSOCUG00000011564 Oryctolagus cuniculus ENSOCUG00000011564 I 0.739
ENSCPOG00000010643 Cavia porcellus ENSCPOG00000010643 I 0.739
RFX5 Echinops telfairi ENSETEG00000013503 I 0.739
RFX5 Equus caballus ENSECAG00000024774 I 0.739
ENSDORG00000015967 Dipodomys ordii ENSDORG00000015967 I 0.739
RFX5 Callithrix jacchus ENSCJAG00000007482 I 0.739
ENSCSAG00000001799 Chlorocebus sabaeus ENSCSAG00000001799 I 0.739
RFX5 Felis catus ENSFCAG00000005568 I 0.739
Rfx5 Rattus norvegicus ENSRNOG00000021012 I 0.738
Rfx5 Mus musculus ENSMUSG00000005774 I 0.738
RFX5 Choloepus hoffmanni ENSCHOG00000012900 I 0.735
RFX5 Erinaceus europaeus ENSEEUG00000010785 I 0.735
ENSLOCG00000013505 Lepisosteus oculatus ENSLOCG00000013505 I 0.721
ENSXMAG00000006676 Xiphophorus maculatus ENSXMAG00000006676 I 0.720
RFX7 Danio rerio ENSDARG00000103691 I 0.720
RFX7 Oryzias latipes ENSORLG00000005342 I 0.720
ENSGMOG00000004164 Gadus morhua ENSGMOG00000004164 I 0.720
ENSAMXG00000014807 Astyanax mexicanus ENSAMXG00000014807 I 0.720
ENSAMXG00000020093 Astyanax mexicanus ENSAMXG00000020093 I 0.720
ENSONIG00000008334 Oreochromis niloticus ENSONIG00000008334 I 0.720
RFX7 Gasterosteus aculeatus ENSGACG00000006090 I 0.720
ENSPMAG00000005066 Petromyzon marinus ENSPMAG00000005066 I 0.718
RFX7 Procavia capensis ENSPCAG00000004974 I 0.716
ENSPANG00000017297 Papio anubis ENSPANG00000017297 I 0.716
ENSAMEG00000018368 Ailuropoda melanoleuca ENSAMEG00000018368 I 0.716
Rfx7 Rattus norvegicus ENSRNOG00000060367 I 0.716
ENSCSAG00000011819 Chlorocebus sabaeus ENSCSAG00000011819 I 0.716
ENSCPOG00000005366 Cavia porcellus ENSCPOG00000005366 I 0.716
ENSTSYG00000002441 Tarsius syrichta ENSTSYG00000002441 I 0.716
RFX7 Vicugna pacos ENSVPAG00000012402 I 0.716
ENSSHAG00000003875 Sarcophilus harrisii ENSSHAG00000003875 I 0.716
RFX7 Choloepus hoffmanni ENSCHOG00000003451 I 0.716
ENSPPYG00000006502 Pongo abelii ENSPPYG00000006502 I 0.716
ENSPSIG00000014731 Pelodiscus sinensis ENSPSIG00000014731 I 0.716
RFX7 Pan troglodytes ENSPTRG00000007104 I 0.716
RFX7 Anolis carolinensis ENSACAG00000008482 I 0.716
RFX7 Dasypus novemcinctus ENSDNOG00000044983 I 0.716
ENSGMOG00000002477 Gadus morhua ENSGMOG00000002477 I 0.716
RFX7 Canis familiaris ENSCAFG00000016029 I 0.716
ENSFALG00000012087 Ficedula albicollis ENSFALG00000012087 I 0.716
ENSMPUG00000002204 Mustela putorius furo ENSMPUG00000002204 I 0.716
RFX7 Meleagris gallopavo ENSMGAG00000005745 I 0.716
ENSAPLG00000005911 Anas platyrhynchos ENSAPLG00000005911 I 0.716
RFX7 Loxodonta africana ENSLAFG00000018745 I 0.716
ENSLACG00000015878 Latimeria chalumnae ENSLACG00000015878 I 0.716
RFX7 Bos taurus ENSBTAG00000000565 I 0.716
Rfx7 Mus musculus ENSMUSG00000037674 D 0.716
RFX7 Monodelphis domestica ENSMODG00000008136 I 0.716
ENSNLEG00000006658 Nomascus leucogenys ENSNLEG00000006658 I 0.716
RFX7 Homo sapiens ENSG00000181827 D 0.716
RFX7 Ornithorhynchus anatinus ENSOANG00000008526 I 0.716
RFX7 Oryctolagus cuniculus ENSOCUG00000013678 I 0.716
rfx7 Xenopus tropicalis XB-GENE-1008447 I 0.715
rfx7 Danio rerio ENSDARG00000077237 I 0.715
RFX7 Pteropus vampyrus ENSPVAG00000005381 I 0.714
RFX7 Otolemur garnettii ENSOGAG00000031795 I 0.713
ENSOARG00000020885 Ovis aries ENSOARG00000020885 I 0.713
RFX7 Tursiops truncatus ENSTTRG00000010051 I 0.713
ENSP00000397644-D1 Bos grunniens ENSP00000397644-D1 I 0.711
Aan_R011989 Calypte anna Aan_R011989 I 0.711
RFX7 Tetraodon nigroviridis ENSTNIG00000013706 I 0.711
Gfo_R004305 Geospiza fortis Gfo_R004305 I 0.711
Afo_R011605 Aptenodytes forsteri Afo_R011605 I 0.711
RFX7 Taeniopygia guttata ENSTGUG00000006356 I 0.711
RFX7 Myotis lucifugus ENSMLUG00000028676 I 0.711
RFX7 Equus caballus ENSECAG00000002379 I 0.711
rfx7 Gasterosteus aculeatus ENSGACG00000015838 I 0.711
RFX7 Takifugu rubripes ENSTRUG00000008008 I 0.711
ENSMMUP00000033587 Macaca fascicularis ENSMMUP00000033587 I 0.710
SPU_027998 Strongylocentrotus purpuratus SPU_027998 I 0.710
RFX7 Sorex araneus ENSSARG00000010801 I 0.710
RFX7 Macaca mulatta ENSMMUG00000017801 I 0.710
RFX7 Felis catus ENSFCAG00000029408 I 0.710
T265_11740 Opisthorchis viverrini T265_11740 I 0.709
csin102559 Clonorchis sinensis csin102559 I 0.709
Myotis_brandtii_RFX7_10006263 Myotis brandtii Myotis_brandtii_RFX7_10006263 I 0.709
Pvit_17399 Pogona vitticeps Pvit_17399 I 0.708
rfx7 Oryzias latipes ENSORLG00000008583 I 0.707
e_gw.237.152.1 Branchiostoma floridae e_gw.237.152.1 I 0.707
Ocbimv22017482m.g Octopus bimaculoides Ocbimv22017482m.g I 0.706
SMU15027042 Schmidtea mediterranea SMU15027042 I 0.705
Brh_R008414 Buceros rhinoceros Brh_R008414 I 0.703
Alligator_sinensis_CCG008945.1 Alligator sinensis Alligator_sinensis_CCG008945.1 I 0.703
RFX7 Erinaceus europaeus ENSEEUG00000013718 I 0.703
ENSXMAG00000003651 Xiphophorus maculatus ENSXMAG00000003651 I 0.702
ENSONIG00000005780 Oreochromis niloticus ENSONIG00000005780 I 0.702
ENSPFOG00000002938 Poecilia formosa ENSPFOG00000002938 I 0.702
RFX7 Echinops telfairi ENSETEG00000015037 I 0.699
A_01977 Schistosoma haematobium A_01977 I 0.698
Smp_040350 Schistosoma mansoni Smp_040350 I 0.698
HmN_000672900 Hymenolepis microstoma HmN_000672900 I 0.698
HDID_0000095701 Hymenolepis diminuta HDID_0000095701 I 0.698
rfx7 Takifugu rubripes ENSTRUG00000017897 I 0.697
rfx7 Tetraodon nigroviridis ENSTNIG00000009322 I 0.697
CapteG131555 Capitella teleta CapteG131555 I 0.696
EmuJ_001055400 Echinococcus multilocularis EmuJ_001055400 I 0.695
HNAJ_0001122601 Hymenolepis nana HNAJ_0001122601 I 0.695
TTAC_0000027401 Hydatigera taeniaeformis TTAC_0000027401 I 0.695
TsM_000553100 Taenia solium TsM_000553100 I 0.695
ECANG7_06078 Echinococcus canadensis ECANG7_06078 I 0.695
NEMVEDRAFT_v1g25228 Nematostella vectensis NEMVEDRAFT_v1g25228 I 0.694
LDEC011897 Leptinotarsa decemlineata LDEC011897 I 0.692
Sjc_0019090 Schistosoma japonicum Sjc_0019090 I 0.689
SROB_0001335501 Schistosoma rodhaini SROB_0001335501 I 0.689
LotgiG138119 Lottia gigantea LotgiG138119 I 0.688
Cmyd_10007628 Chelonia mydas Cmyd_10007628 I 0.688
HMEL011744 Heliconius melpomene HMEL011744 I 0.688
MCINX003210 Melitaea cinxia MCINX003210 I 0.687
KGM_16732 Danaus plexippus KGM_16732 I 0.687
TC008959 Tribolium castaneum TC008959 I 0.686
Hsal_12778--XP_001120516.1_APIME Harpegnathos saltator Hsal_12778--XP_001120516.1_APIME I 0.685
SINV24627 Solenopsis invicta SINV24627 I 0.685
GB49419 Apis mellifera GB49419 I 0.685
ACEP24602 Atta cephalotes ACEP24602 I 0.685
DAPPUDRAFT_64123 Daphnia pulex DAPPUDRAFT_64123 I 0.685
PHUM035280 Pediculus humanus PHUM035280 I 0.684
ENSAPLG00000002900 Anas platyrhynchos ENSAPLG00000002900 I 0.684
NV23037 Nasonia vitripennis NV23037 I 0.683
CGI_10006904 Crassostrea gigas CGI_10006904 I 0.682
L798_03377 Zootermopsis nevadensis L798_03377 I 0.682
LCUP014592 Lucilia cuprina LCUP014592 I 0.681
MDOA009335 Musca domestica MDOA009335 I 0.681
ASIS020285 Anopheles sinensis ASIS020285 I 0.679
ACOM036649 Anopheles coluzzii ACOM036649 I 0.679
AFUN011072 Anopheles funestus AFUN011072 I 0.679
AFAF011654 Anopheles farauti AFAF011654 I 0.679
AMEC002251 Anopheles melas AMEC002251 I 0.679
AMEM009524 Anopheles merus AMEM009524 I 0.679
AMIN003942 Anopheles minimus AMIN003942 I 0.679
AEPI006624 Anopheles epiroticus AEPI006624 I 0.679
ADIR010232 Anopheles dirus ADIR010232 I 0.679
AATE016751 Anopheles atroparvus AATE016751 I 0.679
AARA004226 Anopheles arabiensis AARA004226 I 0.679
ACHR008891 Anopheles christyi ACHR008891 I 0.679
ASTEI04100 Anopheles stephensi ASTEI04100 I 0.679
ACUA017169 Anopheles culicifacies ACUA017169 I 0.679
AALB008384 Anopheles albimanus AALB008384 I 0.679
AQUA006870 Anopheles quadriannulatus AQUA006870 I 0.679
AGAP013226 Anopheles gambiae AGAP013226 I 0.679
ADAC008404 Anopheles darlingi ADAC008404 I 0.679
AAEL013752 Aedes aegypti AAEL013752 I 0.678
CPIJ006094 Culex quinquefasciatus CPIJ006094 I 0.677
CpipJ_CPIJ006094 Culex pipiens CpipJ_CPIJ006094 I 0.677
GG10435 Drosophila erecta FBgn0102744 I 0.676
GF16654 Drosophila ananassae FBgn0093675 I 0.676
BGIBMGA007758 Bombyx mori BGIBMGA007758 I 0.676
GH18082 Drosophila grimshawi FBgn0125550 I 0.676
GJ22650 Drosophila virilis FBgn0209754 I 0.676
GK13786 Drosophila willistoni FBgn0215794 I 0.676
GE24099 Drosophila yakuba FBgn0241238 I 0.676
GA21990 Drosophila pseudoobscura FBgn0081975 I 0.676
CG9727 Drosophila melanogaster FBgn0037445 I 0.676
GI24583 Drosophila mojavensis FBgn0147305 I 0.676
GL22063 Drosophila persimilis FBgn0159655 I 0.676
GD19544 Drosophila simulans FBgn0191039 I 0.676
GM10553 Drosophila sechellia FBgn0165499 I 0.676
XP_002167798.1 Hydra magnipapillata XP_002167798.1 I 0.676
CLEC011984 Cimex lectularius CLEC011984 I 0.674
tetur02g00620 Tetranychus urticae tetur02g00620 I 0.671
Cflo_11342--XP_001120516.1_APIME Camponotus floridanus Cflo_11342--XP_001120516.1_APIME I 0.670
RFX5 Monodelphis domestica ENSMODG00000018866 I 0.668
ENSTSYG00000003230 Tarsius syrichta ENSTSYG00000003230 I 0.667
RFX5 Dasypus novemcinctus ENSDNOG00000035113 I 0.667
ENSSSCG00000024042 Sus scrofa ENSSSCG00000024042 I 0.666
RFX7 Ochotona princeps ENSOPRG00000003155 I 0.666
Ogr11408 Ophisaurus gracilis Ogr11408 I 0.665
ENSMEUG00000007846 Macropus eugenii ENSMEUG00000007846 I 0.665
SCUD_0001838101 Schistosoma curassoni SCUD_0001838101 I 0.661
ISCW001129 Ixodes scapularis ISCW001129 I 0.661
D915_00887 Fasciola hepatica D915_00887 I 0.660
ECPE_0001841201 Echinostoma caproni ECPE_0001841201 I 0.660
Cmyd_10014217 Chelonia mydas Cmyd_10014217 I 0.660
RFX7 Tupaia belangeri ENSTBEG00000014637 I 0.656
PTSG_12063 Salpingoeca rosetta PTSG_12063 I 0.656
fgenesh2_pg.scaffold_3000303 Monosiga brevicollis fgenesh2_pg.scaffold_3000303 I 0.654
CGI_10016120 Crassostrea gigas CGI_10016120 I 0.654
ACYPI002124 Acyrthosiphon pisum ACYPI002124 I 0.653
CAOG_00356 Capsaspora owczarzaki CAOG_00356 I 0.653
GPLIN_000191300 Globodera pallida GPLIN_000191300 I 0.653
ACRE_029400 Acremonium chrysogenum ACRE_029400 I 0.652