NR1I3 (Homo sapiens)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 ENSG00000143257 T303230_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NR1I3
M03924_2.00
Homo sapiens
RGKDYRNNNNRGKKYR

YRMMCYNNNNYRHMCY
SELEX
Nitta et al.(2015)
NR1I3_1
(Direct) (Direct)
NR1I3
M05619_2.00
Homo sapiens
WDAGTTCAH

DTGAACTHW
SELEX
Yin et al.(2017)
NR1I3_FL_HT-SELEX
(Direct) (Direct)
NR1I3
M05620_2.00
Homo sapiens
WDAGTTCRN

NYGAACTHW
SELEX
Yin et al.(2017)
NR1I3_FL_Methyl-HT-SELEX
(Direct) (Direct)
NR1I3
M09281_2.00
Homo sapiens
DRGGTCANNNRAGTTYAN

NTRAACTYNNNTGACCYH
Misc
Kulakovskiy et al.(2013)
NR1I3_HUMAN.H11MO.0.C
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Nr1i3
M09302_2.00
Mus musculus
DRGGTCANNNRAGTTYAN

NTRAACTYNNNTGACCYH
Misc
Kulakovskiy et al.(2013)
NR1I3_MOUSE.H11MO.0.C
0.985 0.886
ENSPMAG00000000180
M02403_2.00
Petromyzon marinus
RGKWCRN

NYGWMCY
PBM
Weirauch et al.(2014)
pTH5509
0.833 0.643
VDR
M03363_2.00
Homo sapiens
GRGTTCAYHGRGTTCA

TGAACYCDRTGAACYC
SELEX
Jolma et al.(2013)
VDR_1
0.822 0.629
Vdr
M03429_2.00
Mus musculus
RRGTTCAYHGRGTTCA

TGAACYCDRTGAACYY
SELEX
Jolma et al.(2013)
Vdr_1
0.822 0.629
VDR
M05877_2.00
Homo sapiens
HRRGTTCA

TGAACYYD
SMiLE-seq
Isakova et al.(2017)
VDR
0.822 0.629
VDR
M09269_2.00
Homo sapiens
NRGGKCANNGRGKKCR

YGMMCYCNNTGMCCYN
Misc
Kulakovskiy et al.(2013)
VDR_HUMAN.H11MO.0.A
0.822 0.629
Vdr
M09315_2.00
Mus musculus
NRGGKCANNGRGKKCR

YGMMCYCNNTGMCCYN
Misc
Kulakovskiy et al.(2013)
VDR_MOUSE.H11MO.0.A
0.822 0.629
VDR
M09606_2.00
Homo sapiens
NRRGGTCANNRRGKKCANNN

NNNTGMMCYYNNTGACCYYN
Misc
Heinz et al.(2010)
GM10855-VDR+vitD_GSE22484
0.822 0.629
VDR
M11116_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q3
0.822 0.629
VDR
M11117_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q6_01
0.822 0.629
VDR
M11118_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q6
0.822 0.629
NR1I2
M03925_2.00
Homo sapiens
RGKKCRNNVRGKKCR

YGMMCYBNNYGMMCY
SELEX
Nitta et al.(2015)
NR1I2_1
0.759 0.586
NR1I2
M05625_2.00
Homo sapiens
VRGTTCRNNSRGKTCRH

DYGAMCYSNNYGAACYB
SELEX
Yin et al.(2017)
NR1I2_eDBD_HT-SELEX
0.759 0.586
NR1I2
M09283_2.00
Homo sapiens
DDRRBTYMDNNRAGKTCAN

NTGAMCTYNNHKRAVYYHH
Misc
Kulakovskiy et al.(2013)
NR1I2_HUMAN.H11MO.0.C
0.759 0.586
NR1I2
M05626_2.00
Homo sapiens
VRGKKCRNNVRGKKCRN

NYGMMCYBNNYGMMCYB
SELEX
Yin et al.(2017)
NR1I2_eDBD_Methyl-HT-SELEX
0.759 0.586
ENSGALG00000028624
M02398_2.00
Gallus gallus
GRGKTCAH

DTGAMCYC
PBM
Weirauch et al.(2014)
pTH6492
0.749 0.643
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000356958 Nuclear receptor 9 78
ENSP00000356959 Nuclear receptor 9 78
ENSP00000356960 Nuclear receptor 5 49
ENSP00000356961 Nuclear receptor 9 78
ENSP00000356962 Nuclear receptor 9 78
ENSP00000356963 Nuclear receptor 9 78
ENSP00000356965 Nuclear receptor 9 78
ENSP00000399361 Nuclear receptor 5 49
ENSP00000406493 Nuclear receptor 9 78
ENSP00000407446 Nuclear receptor 5 49
ENSP00000412672 Nuclear receptor 9 78
ENSP00000421374 Nuclear receptor 9 78
ENSP00000422982 Nuclear receptor 5 49
ENSP00000423007 Nuclear receptor 5 49
ENSP00000423089 Nuclear receptor 5 49
ENSP00000423666 Nuclear receptor 5 49
ENSP00000424345 Nuclear receptor 5 49
ENSP00000424834 Nuclear receptor 5 49
ENSP00000424934 Nuclear receptor 9 78
ENSP00000425417 Nuclear receptor 5 49
ENSP00000425607 Nuclear receptor 5 49
ENSP00000425900 Nuclear receptor 5 49
ENSP00000426016 Nuclear receptor 9 78
ENSP00000426292 Nuclear receptor 9 78
ENSP00000427034 Nuclear receptor 9 78
ENSP00000427175 Nuclear receptor 5 49
ENSP00000427600 Nuclear receptor 5 49
ENSP00000487337 Nuclear receptor 9 78

Links

Other Nuclear receptor family TFs
Other Homo sapiens TFs

145 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
NR1I3 Callithrix jacchus ENSCJAG00000004783 I 0.993
ENSNLEG00000014287 Nomascus leucogenys ENSNLEG00000014287 I 0.993
NR1I3 Pan troglodytes ENSPTRG00000001582 I 0.993
ENSP00000356959 Macaca fascicularis ENSP00000356959 I 0.992
ENSCSAG00000002676 Chlorocebus sabaeus ENSCSAG00000002676 I 0.992
ENSPANG00000014194 Papio anubis ENSPANG00000014194 I 0.992
NR1I3 Macaca mulatta ENSMMUG00000018128 I 0.992
NR1I3 Gorilla gorilla ENSGGOG00000005724 I 0.992
Nr1i3 Rattus norvegicus ENSRNOG00000003260 I 0.985
Nr1i3 Mus musculus ENSMUSG00000005677 D 0.985
NR1I3 Otolemur garnettii ENSOGAG00000013738 I 0.982
ENSDORG00000001701 Dipodomys ordii ENSDORG00000001701 I 0.981
NR1I3 Procavia capensis ENSPCAG00000013933 I 0.974
NR1I3 Loxodonta africana ENSLAFG00000001180 I 0.974
NR1I3 Canis familiaris ENSCAFG00000012921 I 0.972
NR1I3 Dasypus novemcinctus ENSDNOG00000045179 I 0.971
ENSOARG00000009965 Ovis aries ENSOARG00000009965 I 0.970
ENSSHAG00000016687 Sarcophilus harrisii ENSSHAG00000016687 I 0.969
NR1I3 Oryctolagus cuniculus ENSOCUG00000013537 I 0.968
ENSMEUG00000001987 Macropus eugenii ENSMEUG00000001987 I 0.968
NR1I3 Felis catus ENSFCAG00000000497 I 0.968
NR1I3 Equus caballus ENSECAG00000020930 I 0.968
ENSMPUG00000014388 Mustela putorius furo ENSMPUG00000014388 I 0.967
NR1I3 Monodelphis domestica ENSMODG00000005089 I 0.966
NR1I3 Erinaceus europaeus ENSEEUG00000004981 I 0.965
NR1I3 Ochotona princeps ENSOPRG00000003455 I 0.962
NR1I3 Bos taurus ENSBTAG00000009215 I 0.961
NR1I3 Pteropus vampyrus ENSPVAG00000005540 I 0.961
ENSP00000356959-D1 Bos grunniens ENSP00000356959-D1 I 0.961
NR1I3 Sus scrofa ENSSSCG00000006353 I 0.961
ENSSTOG00000003818 Ictidomys tridecemlineatus ENSSTOG00000003818 I 0.954
NR1I3 Sorex araneus ENSSARG00000002684 I 0.951
NR1I3 Cavia porcellus ENSCPOG00000015331 I 0.951
ENSTSYG00000003712 Tarsius syrichta ENSTSYG00000003712 I 0.945
ENSAMEG00000015383 Ailuropoda melanoleuca ENSAMEG00000015383 I 0.934
Alligator_sinensis_CCG006068.1 Alligator sinensis Alligator_sinensis_CCG006068.1 I 0.881
NR1I2 Otolemur garnettii ENSOGAG00000006017 I 0.858
nr1i2.L Xenopus laevis XB-GENE-17336519 I 0.855
nr1i2.S Xenopus laevis XB-GENE-865343 I 0.852
Ogr03312 Ophisaurus gracilis Ogr03312 I 0.851
NR1I3 Tursiops truncatus ENSTTRG00000009227 I 0.851
NR1I2 Bos taurus ENSBTAG00000019557 I 0.840
ENSP00000336528-D1 Bos grunniens ENSP00000336528-D1 I 0.840
NR1I2 Sus scrofa ENSSSCG00000011890 I 0.840
ENSGMOG00000019451 Gadus morhua ENSGMOG00000019451 I 0.835
vdra Gasterosteus aculeatus ENSGACG00000004763 I 0.835
vdrb Danio rerio ENSDARG00000070721 I 0.835
ENSXMAG00000018707 Xiphophorus maculatus ENSXMAG00000018707 I 0.835
vdralpha Oryzias latipes ENSORLG00000001063 I 0.835
vdr Oryzias latipes ENSORLG00000016402 I 0.835
ENSPFOG00000014233 Poecilia formosa ENSPFOG00000014233 I 0.835
ENSAMXG00000019854 Astyanax mexicanus ENSAMXG00000019854 I 0.835
ENSXMAG00000004608 Xiphophorus maculatus ENSXMAG00000004608 I 0.835
ENSONIG00000009200 Oreochromis niloticus ENSONIG00000009200 I 0.835
ENSPFOG00000001655 Poecilia formosa ENSPFOG00000001655 I 0.835
vdrb Takifugu rubripes ENSTRUG00000011576 I 0.835
vdrb Tetraodon nigroviridis ENSTNIG00000007031 I 0.835
vdra Takifugu rubripes ENSTRUG00000011907 I 0.835
vdrb Gasterosteus aculeatus ENSGACG00000007975 I 0.835
ENSGMOG00000012720 Gadus morhua ENSGMOG00000012720 I 0.833
ENSPMAG00000000180 Petromyzon marinus ENSPMAG00000000180 D 0.833
ENSAMXG00000012991 Astyanax mexicanus ENSAMXG00000012991 I 0.833
ENSPSIG00000004437 Pelodiscus sinensis ENSPSIG00000004437 I 0.832
Cmyd_10001928 Chelonia mydas Cmyd_10001928 I 0.831
ENSLOCG00000005194 Lepisosteus oculatus ENSLOCG00000005194 I 0.830
ENSONIG00000019378 Oreochromis niloticus ENSONIG00000019378 I 0.830
VDR Anolis carolinensis ENSACAG00000013485 I 0.825
VDR Taeniopygia guttata ENSTGUG00000017093 I 0.825
HelroG108893 Helobdella robusta HelroG108893 I 0.825
Aan_R009572 Calypte anna Aan_R009572 I 0.825
Pvit_07440 Pogona vitticeps Pvit_07440 I 0.825
Gfo_R005027 Geospiza fortis Gfo_R005027 I 0.825
ENSLACG00000019104 Latimeria chalumnae ENSLACG00000019104 I 0.825
ENSGALG00000026166 Gallus gallus ENSGALG00000026166 I 0.825
VDR Meleagris gallopavo ENSMGAG00000004846 I 0.825
ENSP00000229022-D1 Bos grunniens ENSP00000229022-D1 I 0.822
VDR Sus scrofa ENSSSCG00000020864 I 0.822
Vdr Rattus norvegicus ENSRNOG00000054420 I 0.822
Myotis_brandtii_VDR_10022134 Myotis brandtii Myotis_brandtii_VDR_10022134 I 0.822
ENSMMUP00000008847 Macaca fascicularis ENSMMUP00000008847 I 0.822
VDR Tupaia belangeri ENSTBEG00000005717 I 0.822
VDR Pteropus vampyrus ENSPVAG00000011085 I 0.822
VDR Tursiops truncatus ENSTTRG00000012578 I 0.822
ENSSTOG00000026741 Ictidomys tridecemlineatus ENSSTOG00000026741 I 0.822
ENSPPYG00000004448 Pongo abelii ENSPPYG00000004448 I 0.822
ENSOARG00000019372 Ovis aries ENSOARG00000019372 I 0.822
VDR Canis familiaris ENSCAFG00000009103 I 0.822
ENSPANG00000011327 Papio anubis ENSPANG00000011327 I 0.822
VDR Homo sapiens ENSG00000111424 D 0.822
VDR Bos taurus ENSBTAG00000016414 I 0.822
VDR Gorilla gorilla ENSGGOG00000016473 I 0.822
VDR Microcebus murinus ENSMICG00000009017 I 0.822
ENSMEUG00000014791 Macropus eugenii ENSMEUG00000014791 I 0.822
VDR Felis catus ENSFCAG00000024594 I 0.822
VDR Erinaceus europaeus ENSEEUG00000011116 I 0.822
ENSCSAG00000006576 Chlorocebus sabaeus ENSCSAG00000006576 I 0.822
ENSCPOG00000006025 Cavia porcellus ENSCPOG00000006025 I 0.822
VDR Callithrix jacchus ENSCJAG00000015018 I 0.822
VDR Dasypus novemcinctus ENSDNOG00000039161 I 0.822
ENSCHOG00000008514 Choloepus hoffmanni ENSCHOG00000008514 I 0.822
VDR Equus caballus ENSECAG00000015822 I 0.822
VDR Myotis lucifugus ENSMLUG00000000912 I 0.822
VDR Loxodonta africana ENSLAFG00000006418 I 0.822
ENSNLEG00000017900 Nomascus leucogenys ENSNLEG00000017900 I 0.822
ENSMODG00000028774 Monodelphis domestica ENSMODG00000028774 I 0.822
ENSMPUG00000000419 Mustela putorius furo ENSMPUG00000000419 I 0.822
Vdr Mus musculus ENSMUSG00000022479 D 0.822
VDR Oryctolagus cuniculus ENSOCUG00000027507 I 0.822
VDR Macaca mulatta ENSMMUG00000006727 I 0.822
ENSAMEG00000013706 Ailuropoda melanoleuca ENSAMEG00000013706 I 0.822
VDR Otolemur garnettii ENSOGAG00000005480 I 0.822
Pvit_09406 Pogona vitticeps Pvit_09406 I 0.814
Pvit_09404 Pogona vitticeps Pvit_09404 I 0.814
Afo_R013462 Aptenodytes forsteri Afo_R013462 I 0.812
Cmyd_10006875 Chelonia mydas Cmyd_10006875 I 0.812
NR1I2 Canis familiaris ENSCAFG00000011094 I 0.812
ENSPSIG00000018108 Pelodiscus sinensis ENSPSIG00000018108 I 0.812
ENSPMAG00000003695 Petromyzon marinus ENSPMAG00000003695 I 0.802
ENSSHAG00000004437 Sarcophilus harrisii ENSSHAG00000004437 I 0.795
vdr.S Xenopus laevis XB-GENE-864847 I 0.794
vdr Xenopus tropicalis XB-GENE-486505 I 0.794
NEMVEDRAFT_v1g165424 Nematostella vectensis NEMVEDRAFT_v1g165424 I 0.788
ENSACAG00000001535 Anolis carolinensis ENSACAG00000001535 I 0.784
ENSLACG00000010334 Latimeria chalumnae ENSLACG00000010334 I 0.781
NR1I2 Myotis lucifugus ENSMLUG00000002877 I 0.776
Myotis_brandtii_NR1I2_10031787 Myotis brandtii Myotis_brandtii_NR1I2_10031787 I 0.776
ENSMEUG00000000113 Macropus eugenii ENSMEUG00000000113 I 0.768
ENSP00000336528 Macaca fascicularis ENSP00000336528 I 0.759
NR1I2 Callithrix jacchus ENSCJAG00000008854 I 0.759
ENSAMEG00000007006 Ailuropoda melanoleuca ENSAMEG00000007006 I 0.759
ENSTSYG00000010757 Tarsius syrichta ENSTSYG00000010757 I 0.759
NR1I2 Gorilla gorilla ENSGGOG00000007361 I 0.759
NR1I2 Macaca mulatta ENSMMUG00000001976 I 0.759
ENSNLEG00000005060 Nomascus leucogenys ENSNLEG00000005060 I 0.759
NR1I2 Felis catus ENSFCAG00000006092 I 0.759
NR1I2 Homo sapiens ENSG00000144852 D 0.759
NR1I2 Equus caballus ENSECAG00000008728 I 0.759
NR1I2 Pan troglodytes ENSPTRG00000015263 I 0.759
NR1I2 Echinops telfairi ENSETEG00000018117 I 0.759
nr1i2 Danio rerio ENSDARG00000029766 I 0.755
vdra Tetraodon nigroviridis ENSTNIG00000005559 I 0.752
NR1I2 Pteropus vampyrus ENSPVAG00000000884 I 0.750
ENSGALG00000028624 Gallus gallus ENSGALG00000028624 D 0.749
Q9DFH3_CHICK Gallus gallus Q9DFH3_CHICK I 0.749