nhr-70 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003660 T306184_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-70
M00695_2.00		 Caenorhabditis elegans
NYTGTAGYYD
HRRCTACARN		 PBM
Narasimhan et al.(2015)
pTH9174		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-86
M02415_2.00 		Caenorhabditis elegans
KTGTAGTC
GACTACAM		 PBM
Weirauch et al.(2014)
pTH8598 		0.849 0.686
For this family, TFs with SR scores > 0.745 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00695_2.00 Nuclear receptor 9 78

DNA Binding Domains

Protein ID Domain From To Sequence
Y51A2D.17 Nuclear receptor 9 78

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

34 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE07801 Caenorhabditis remanei CRE07801 I 0.985
CBG20699 Caenorhabditis briggsae CBG20699 I 0.984
CJA10576 Caenorhabditis japonica CJA10576 I 0.907
CBG16375 Caenorhabditis briggsae CBG16375 I 0.894
nhr-28 Caenorhabditis elegans WBGene00003624 I 0.891
CRE18529 Caenorhabditis remanei CRE18529 I 0.867
CBG12152 Caenorhabditis briggsae CBG12152 I 0.867
CBN04619 Caenorhabditis brenneri CBN04619 I 0.865
nhr-109 Caenorhabditis elegans WBGene00003699 I 0.859
nhr-273 Caenorhabditis elegans WBGene00020460 I 0.857
CRE27659 Caenorhabditis remanei CRE27659 I 0.856
CBN03440 Caenorhabditis brenneri CBN03440 I 0.850
nhr-86 Caenorhabditis elegans WBGene00003676 D 0.849
CBN16902 Caenorhabditis brenneri CBN16902 I 0.831
BXY_1189000 Bursaphelenchus xylophilus BXY_1189000 I 0.830
CRE27174 Caenorhabditis remanei CRE27174 I 0.812
L893_g4569 Steinernema glaseri L893_g4569 I 0.810
L892_g8145 Steinernema scapterisci L892_g8145 I 0.810
CBN22974 Caenorhabditis brenneri CBN22974 I 0.810
BXY_1091200 Bursaphelenchus xylophilus BXY_1091200 I 0.809
nhr-12 Caenorhabditis elegans WBGene00003611 I 0.802
L889_g9698 Steinernema feltiae L889_g9698 I 0.777
L889_g987 Steinernema feltiae L889_g987 I 0.777
nhr-53 Caenorhabditis elegans WBGene00003643 I 0.772
nhr-16 Caenorhabditis elegans WBGene00003615 I 0.767
CBN03769 Caenorhabditis brenneri CBN03769 I 0.767
CBN24070 Caenorhabditis brenneri CBN24070 I 0.767
L889_g10781 Steinernema feltiae L889_g10781 I 0.762
CRE09011 Caenorhabditis remanei CRE09011 I 0.760
CRE17354 Caenorhabditis remanei CRE17354 I 0.760
CJA04414 Caenorhabditis japonica CJA04414 I 0.755
CJA07390 Caenorhabditis japonica CJA07390 I 0.755
SMUV_0000801801 Syphacia muris SMUV_0000801801 I 0.752
CBG04789 Caenorhabditis briggsae CBG04789 I 0.746