nhr-12 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003611 T306136_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head ganglion and tail ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); hepatocellular carcinoma; lipid metabolism disorder; and type 2 diabetes mellitus. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha) and PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-86
M02415_2.00 		Caenorhabditis elegans
KTGTAGTC
GACTACAM		 PBM
Weirauch et al.(2014)
pTH8598 		0.895 0.686
nhr-70
M00695_2.00 		Caenorhabditis elegans
NYTGTAGYYD
HRRCTACARN		 PBM
Narasimhan et al.(2015)
pTH9174 		0.802 0.657
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
R04B5.4a Nuclear receptor 45 114
R04B5.4b Nuclear receptor 45 114
R04B5.4c Nuclear receptor 45 114

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

55 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBN16902 Caenorhabditis brenneri CBN16902 I 0.986
CRE27174 Caenorhabditis remanei CRE27174 I 0.984
CJA07390 Caenorhabditis japonica CJA07390 I 0.955
CJA04414 Caenorhabditis japonica CJA04414 I 0.955
CBN03769 Caenorhabditis brenneri CBN03769 I 0.923
L889_g987 Steinernema feltiae L889_g987 I 0.918
L889_g9698 Steinernema feltiae L889_g9698 I 0.918
CBG16375 Caenorhabditis briggsae CBG16375 I 0.908
nhr-28 Caenorhabditis elegans WBGene00003624 I 0.906
L893_g4569 Steinernema glaseri L893_g4569 I 0.905
L892_g8145 Steinernema scapterisci L892_g8145 I 0.905
CBN04619 Caenorhabditis brenneri CBN04619 I 0.904
CRE18529 Caenorhabditis remanei CRE18529 I 0.900
nhr-86 Caenorhabditis elegans WBGene00003676 D 0.895
nhr-273 Caenorhabditis elegans WBGene00020460 I 0.895
CBG12152 Caenorhabditis briggsae CBG12152 I 0.894
CRE17355 Caenorhabditis remanei CRE17355 I 0.886
CJA10576 Caenorhabditis japonica CJA10576 I 0.886
nhr-109 Caenorhabditis elegans WBGene00003699 I 0.879
CRE27659 Caenorhabditis remanei CRE27659 I 0.875
L889_g10781 Steinernema feltiae L889_g10781 I 0.874
SMUV_0000801801 Syphacia muris SMUV_0000801801 I 0.853
CBN18264 Caenorhabditis brenneri CBN18264 I 0.840
CRE17310 Caenorhabditis remanei CRE17310 I 0.838
CBG03687 Caenorhabditis briggsae CBG03687 I 0.835
SMUV_0000886001 Syphacia muris SMUV_0000886001 I 0.833
CBG20699 Caenorhabditis briggsae CBG20699 I 0.828
CBG03688 Caenorhabditis briggsae CBG03688 I 0.828
CBG04789 Caenorhabditis briggsae CBG04789 I 0.820
CRE09011 Caenorhabditis remanei CRE09011 I 0.819
BXY_1188900 Bursaphelenchus xylophilus BXY_1188900 N 0.818
CRE17354 Caenorhabditis remanei CRE17354 I 0.806
CRE07801 Caenorhabditis remanei CRE07801 I 0.804
nhr-70 Caenorhabditis elegans WBGene00003660 D 0.802
CBN24070 Caenorhabditis brenneri CBN24070 I 0.801
PPA29361 Pristionchus pacificus PPA29361 I 0.799
CBN03440 Caenorhabditis brenneri CBN03440 I 0.786
nhr-53 Caenorhabditis elegans WBGene00003643 I 0.786
CBG01395 Caenorhabditis briggsae CBG01395 N 0.785
L893_g2090 Steinernema glaseri L893_g2090 I 0.783
ASIM_0000109601 Anisakis simplex ASIM_0000109601 N 0.782
L892_g8140 Steinernema scapterisci L892_g8140 I 0.780
EVEC_0001266201 Enterobius vermicularis EVEC_0001266201 I 0.778
NECAME_01500 Necator americanus NECAME_01500 I 0.777
scaffold183-EXSNAP2012.18 Pristionchus exspectatus scaffold183-EXSNAP2012.18 I 0.774
PPA08785 Pristionchus pacificus PPA08785 I 0.774
scaffold260-EXSNAP2012.15 Pristionchus exspectatus scaffold260-EXSNAP2012.15 I 0.771
PPA10478 Pristionchus pacificus PPA10478 I 0.771
scaffold1235-EXSNAP2012.2 Pristionchus exspectatus scaffold1235-EXSNAP2012.2 I 0.764
L892_g8144 Steinernema scapterisci L892_g8144 I 0.763
L893_g9517 Steinernema glaseri L893_g9517 I 0.758
TCNE_0001892601 Toxocara canis TCNE_0001892601 N 0.749
L898_g28806 Steinernema monticolum L898_g28806 I 0.749
L596_g27786 Steinernema carpocapsae L596_g27786 I 0.748