toy (Drosophila melanogaster)
Homeodomain,Paired box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00292 (PAX) 		IPR001356
IPR001523 		FBgn0019650 T237541_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
toy
M03899_2.00		 Drosophila melanogaster
TTYACGCWTGASTGMACAN
NTGTKCASTCAWGCGTRAA		 SELEX
Nitta et al.(2015)
toy_1		 (Direct) (Direct)
toy
M03900_2.00		 Drosophila melanogaster
NTYACGCWTSAVTGMRCNN
NNGYKCABTSAWGCGTRAN		 SELEX
Nitta et al.(2015)
toy_2		 (Direct) (Direct)
toy
M03901_2.00		 Drosophila melanogaster
VATTANBHAYGSWYSRN
NYSRWSCRTDVNTAATB		 SELEX
Nitta et al.(2015)
toy_3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ey
M03896_2.00 		Drosophila melanogaster
CKAATTAD
HTAATTMG		 SELEX
Nitta et al.(2015)
ey_1 		0.912 0.912
ey
M03897_2.00 		Drosophila melanogaster
HTAATCKMATTAD
HTAATKMGATTAD		 SELEX
Nitta et al.(2015)
ey_2 		0.912 0.912
ey
M03898_2.00 		Drosophila melanogaster
WAAYYRRTTN
NAAYYRRTTW		 SELEX
Nitta et al.(2015)
ey_3 		0.912 0.912
PAX6
M00342_2.00 		Homo sapiens
NNNRCDMATTANNN
NNNTAATKHGYNNN		 PBM
Barrera et al.(2016)
PAX6_REF 		0.907 0.907
Pax6
M00540_2.00 		Mus musculus
CBAATTAA
TTAATTVG		 PBM
Berger et al.(2008)
Pax6_3838 		0.907 0.907
PAX6
M03291_2.00 		Homo sapiens
DTWYACGCWTGANTGMDYH
DRHKCANTCAWGCGTRWAH		 SELEX
Jolma et al.(2013)
PAX6_1 		0.907 0.907
PAX6
M05412_2.00 		Homo sapiens
NYACGCHYSRNYRMNYN
NRNKYRNYSRDGCGTRN		 SELEX
Yin et al.(2017)
PAX6_eDBD_HT-SELEX 		0.907 0.907
PAX6
M05414_2.00 		Homo sapiens
NYRCGCNYSRNYRVNYN
NRNBYRNYSRNGCGYRN		 SELEX
Yin et al.(2017)
PAX6_FL_HT-SELEX 		0.907 0.907
PAX6
M02689_2.00 		Homo sapiens
TTYACGCWTSANTK
MANTSAWGCGTRAA		 SELEX
Mathelier et al.(2014)
MA0069.1 		0.907 0.907
PAX6
M09216_2.00 		Homo sapiens
TYMYRCWTSRNT
ANYSAWGYRKRA		 Misc
Kulakovskiy et al.(2013)
PAX6_HUMAN.H11MO.0.C 		0.907 0.907
Pax6
M09217_2.00 		Mus musculus
TYMYRCWTSRNT
ANYSAWGYRKRA		 Misc
Kulakovskiy et al.(2013)
PAX6_MOUSE.H11MO.0.C 		0.907 0.907
PAX6
M10806_2.00 		Homo sapiens
NHNNTTYACGCWTSANTKVHH
DDBMANTSAWGCGTRAANNDN		 Transfac
Matys et al.(2006)
V$PAX6_01 		0.907 0.907
PAX6
M10807_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX6_Q2 		0.907 0.907
PAX6
M05413_2.00 		Homo sapiens
DYRCGCWTSRNYRMNYN
NRNKYRNYSAWGCGYRH		 SELEX
Yin et al.(2017)
PAX6_eDBD_Methyl-HT-SELEX 		0.907 0.907
PAX6
M05415_2.00 		Homo sapiens
NYACGCHYSRNYRMHYN
NRDKYRNYSRDGCGTRN		 SELEX
Yin et al.(2017)
PAX6_FL_Methyl-HT-SELEX 		0.907 0.907
PAX6
M00335_2.00 		Homo sapiens
BRNNNNNN
NNNNNNYV		 PBM
Barrera et al.(2016)
PAX6_A79E 		0.901 0.901
PAX6
M00336_2.00 		Homo sapiens
RTGCACAC
GTGTGCAY		 PBM
Barrera et al.(2016)
PAX6_F258S 		0.901 0.901
PAX6
M00337_2.00 		Homo sapiens
NMTAATTANNN
NNNTAATTAKN		 PBM
Barrera et al.(2016)
PAX6_P118R 		0.901 0.901
PAX6
M00338_2.00 		Homo sapiens
WSGVRVDR
YHBYBCSW		 PBM
Barrera et al.(2016)
PAX6_P68S 		0.901 0.901
PAX6
M00339_2.00 		Homo sapiens
NNNNSGKVGGHNN
NNDCCBMCSNNNN		 PBM
Barrera et al.(2016)
PAX6_R128C 		0.901 0.901
PAX6
M00340_2.00 		Homo sapiens
NNNNNRN
NYNNNNN		 PBM
Barrera et al.(2016)
PAX6_R242T 		0.901 0.901
PAX6
M00341_2.00 		Homo sapiens
BTSCCCSGSC
GSCSGGGSAV		 PBM
Barrera et al.(2016)
PAX6_R26G 		0.901 0.901
PAX6
M00343_2.00 		Homo sapiens
NNNNCCCVKCNBN
NVNGMBGGGNNNN		 PBM
Barrera et al.(2016)
PAX6_S119R 		0.901 0.901
PAX6
M00344_2.00 		Homo sapiens
NNMSASGBYNNN
NNNRVCSTSKNN		 PBM
Barrera et al.(2016)
PAX6_V126D 		0.901 0.901
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0088249 Paired box 29 153
FBpp0088249 Homeodomain 266 322
FBpp0308592 Paired box 29 153
FBpp0308592 Homeodomain 266 318

Links

Other Homeodomain,Paired box family TFs
Other Drosophila melanogaster TFs

191 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GG16402 Drosophila erecta FBgn0108634 I 1.000
GD24416 Drosophila simulans FBgn0195753 I 1.000
GM13021 Drosophila sechellia FBgn0167952 I 1.000
GE14563 Drosophila yakuba FBgn0232162 I 1.000
GA27636 Drosophila pseudoobscura FBgn0249001 I 0.989
GF21877 Drosophila ananassae FBgn0098877 I 0.989
GH23963 Drosophila grimshawi FBgn0131420 I 0.989
GI14042 Drosophila mojavensis FBgn0136796 I 0.989
GL17563 Drosophila persimilis FBgn0155166 I 0.989
GJ13300 Drosophila virilis FBgn0200526 I 0.989
GK13683 Drosophila willistoni FBgn0215691 I 0.989
Cflo_00481--XP_394648.3_APIME Camponotus floridanus Cflo_00481--XP_394648.3_APIME I 0.967
NV17076 Nasonia vitripennis NV17076 I 0.967
GB41504 Apis mellifera GB41504 I 0.967
Hsal_09597--XP_394648.3_APIME Harpegnathos saltator Hsal_09597--XP_394648.3_APIME I 0.967
PHUM097050 Pediculus humanus PHUM097050 I 0.965
TC007409 Tribolium castaneum TC007409 I 0.956
L798_00712 Zootermopsis nevadensis L798_00712 I 0.956
DAPPUDRAFT_249978 Daphnia pulex DAPPUDRAFT_249978 I 0.945
ACYPI008177 Acyrthosiphon pisum ACYPI008177 I 0.945
SMAR013763 Strigamia maritima SMAR013763 I 0.929
ENSGACG00000002490 Gasterosteus aculeatus ENSGACG00000002490 I 0.918
L798_11483 Zootermopsis nevadensis L798_11483 I 0.917
ENSNLEG00000017888 Nomascus leucogenys ENSNLEG00000017888 I 0.912
ey Drosophila melanogaster FBgn0005558 D 0.912
PAX6 Oryctolagus cuniculus ENSOCUG00000011075 I 0.912
Pax6 Rattus norvegicus ENSRNOG00000004410 I 0.912
ENSPSIG00000012748 Pelodiscus sinensis ENSPSIG00000012748 I 0.912
PAX6 Otolemur garnettii ENSOGAG00000007857 I 0.912
ey Drosophila pseudoobscura FBgn0018538 I 0.912
ACYPI067710 Acyrthosiphon pisum ACYPI067710 I 0.912
NV15820 Nasonia vitripennis NV15820 I 0.912
ENSP00000368424 Macaca fascicularis ENSP00000368424 I 0.912
ENSP00000368401-D1 Bos grunniens ENSP00000368401-D1 I 0.912
PAX6 Loxodonta africana ENSLAFG00000015520 I 0.912
GK13702 Drosophila willistoni FBgn0215710 I 0.912
GI14081 Drosophila mojavensis FBgn0136835 I 0.912
TC008176 Tribolium castaneum TC008176 I 0.912
ey Drosophila persimilis FBgn0043659 I 0.912
GB50342 Apis mellifera GB50342 I 0.912
pax6a Danio rerio ENSDARG00000103379 I 0.912
ENSAMEG00000006908 Ailuropoda melanoleuca ENSAMEG00000006908 I 0.912
PAX6 Felis catus ENSFCAG00000007094 I 0.912
PAX6 Cavia porcellus ENSCPOG00000007245 I 0.912
PAX6 Gorilla gorilla ENSGGOG00000010246 I 0.912
ADAC001560 Anopheles darlingi ADAC001560 I 0.910
PAX6 Dasypus novemcinctus ENSDNOG00000000761 I 0.907
GG16399 Drosophila erecta FBgn0108631 I 0.907
GF22818 Drosophila ananassae FBgn0099812 I 0.907
ey Drosophila sechellia FBgn0068720 I 0.907
PAX6 Tupaia belangeri ENSTBEG00000004748 I 0.907
pax6b Tetraodon nigroviridis ENSTNIG00000013804 I 0.907
ENSXMAG00000014260 Xiphophorus maculatus ENSXMAG00000014260 I 0.907
PAX6 Homo sapiens ENSG00000007372 D 0.907
ey Drosophila virilis FBgn0028754 I 0.907
ENSCSAG00000005253 Chlorocebus sabaeus ENSCSAG00000005253 I 0.907
Sakowv30026828m.g Saccoglossus kowalevskii Sakowv30026828m.g I 0.907
Pvit_09512 Pogona vitticeps Pvit_09512 I 0.907
pax6 Xenopus tropicalis XB-GENE-484088 I 0.907
pax6.S Xenopus laevis XB-GENE-6464331 I 0.907
D918_01592 Trichuris suis D918_01592 I 0.907
PAX6 Anolis carolinensis ENSACAG00000002252 I 0.907
Alligator_sinensis_CCG012954.1 Alligator sinensis Alligator_sinensis_CCG012954.1 I 0.907
GE14559 Drosophila yakuba FBgn0232158 I 0.907
ENSSTOG00000003211 Ictidomys tridecemlineatus ENSSTOG00000003211 I 0.907
PAX6 Callithrix jacchus ENSCJAG00000005942 I 0.907
ENSLACG00000015337 Latimeria chalumnae ENSLACG00000015337 I 0.907
pax6b Danio rerio ENSDARG00000045936 I 0.907
PAX6 Bos taurus ENSBTAG00000004561 I 0.907
PAX6 Microcebus murinus ENSMICG00000004089 I 0.907
ENSGMOG00000012304 Gadus morhua ENSGMOG00000012304 I 0.907
PAX6 Gallus gallus ENSGALG00000012123 I 0.907
PAX6 Ochotona princeps ENSOPRG00000001678 I 0.907
PAX6 Procavia capensis ENSPCAG00000005165 I 0.907
ENSLOCG00000004578 Lepisosteus oculatus ENSLOCG00000004578 I 0.907
ENSPANG00000005448 Papio anubis ENSPANG00000005448 I 0.907
pax6b Oryzias latipes ENSORLG00000009913 I 0.907
ENSOARG00000016191 Ovis aries ENSOARG00000016191 I 0.907
Pax6 Mus musculus ENSMUSG00000027168 D 0.907
PAX6 Macaca mulatta ENSMMUG00000016810 I 0.907
ENSSHAG00000016310 Sarcophilus harrisii ENSSHAG00000016310 I 0.907
PAX6 Myotis lucifugus ENSMLUG00000006517 I 0.907
PAX6 Sus scrofa ENSSSCG00000013320 I 0.907
ENSMPUG00000011295 Mustela putorius furo ENSMPUG00000011295 I 0.907
ADIR000973 Anopheles dirus ADIR000973 I 0.906
AFUN011570 Anopheles funestus AFUN011570 I 0.906
ACHR009845 Anopheles christyi ACHR009845 I 0.906
ASTEI06205 Anopheles stephensi ASTEI06205 I 0.906
AATE014626 Anopheles atroparvus AATE014626 I 0.906
AMIN002132 Anopheles minimus AMIN002132 I 0.906
PAX6 Sorex araneus ENSSARG00000011424 I 0.902
ENSAMXG00000013008 Astyanax mexicanus ENSAMXG00000013008 I 0.901
pax6b Takifugu rubripes ENSTRUG00000006935 I 0.901
TTRE_0000173501 Trichuris trichiura TTRE_0000173501 I 0.901
pax6.L Xenopus laevis XB-GENE-865046 I 0.901
ENSONIG00000005541 Oreochromis niloticus ENSONIG00000005541 I 0.901
ENSXMAG00000016421 Xiphophorus maculatus ENSXMAG00000016421 I 0.901
pax6b Gasterosteus aculeatus ENSGACG00000016030 I 0.901
ENSPFOG00000016987 Poecilia formosa ENSPFOG00000016987 I 0.901
TMUE_s0038005250 Trichuris muris TMUE_s0038005250 I 0.901
Cmyd_10016391 Chelonia mydas Cmyd_10016391 I 0.900
ENSAMXG00000001228 Astyanax mexicanus ENSAMXG00000001228 I 0.896
DAPPUDRAFT_249991 Daphnia pulex DAPPUDRAFT_249991 I 0.896
ENSGMOG00000019087 Gadus morhua ENSGMOG00000019087 I 0.896
ENSONIG00000004074 Oreochromis niloticus ENSONIG00000004074 I 0.896
SMU15027897 Schmidtea mediterranea SMU15027897 I 0.896
ENSPPYG00000003386 Pongo abelii ENSPPYG00000003386 I 0.892
ENSORLG00000000847 Oryzias latipes ENSORLG00000000847 I 0.890
ENSTRUG00000017375 Takifugu rubripes ENSTRUG00000017375 I 0.890
PAX6 Echinops telfairi ENSETEG00000002655 I 0.890
ENSTNIG00000002471 Tetraodon nigroviridis ENSTNIG00000002471 I 0.885
PAX6 Equus caballus ENSECAG00000021000 I 0.885
ISCW021772 Ixodes scapularis ISCW021772 I 0.884
LotgiG133720 Lottia gigantea LotgiG133720 I 0.879
CGI_10027695 Crassostrea gigas CGI_10027695 I 0.879
PAX6 Monodelphis domestica ENSMODG00000009611 I 0.874
MCINX016249 Melitaea cinxia MCINX016249 I 0.874
ASIS012617 Anopheles sinensis ASIS012617 I 0.867
ENSCING00000006503 Ciona intestinalis ENSCING00000006503 I 0.863
ENSCSAVG00000007987 Ciona savignyi ENSCSAVG00000007987 I 0.863
AALB006643 Anopheles albimanus AALB006643 I 0.857
ACUA016154 Anopheles culicifacies ACUA016154 I 0.857
AARA001110 Anopheles arabiensis AARA001110 I 0.852
L892_g3713 Steinernema scapterisci L892_g3713 I 0.852
CPIJ006398 Culex quinquefasciatus CPIJ006398 I 0.852
CpipJ_CPIJ006398 Culex pipiens CpipJ_CPIJ006398 I 0.852
AQUA008313 Anopheles quadriannulatus AQUA008313 I 0.852
AEPI005798 Anopheles epiroticus AEPI005798 I 0.852
AGAP000067 Anopheles gambiae AGAP000067 I 0.852
AFAF017899 Anopheles farauti AFAF017899 I 0.852
AMEC013051 Anopheles melas AMEC013051 I 0.852
AMEM002691 Anopheles merus AMEM002691 I 0.852
L596_g12356 Steinernema carpocapsae L596_g12356 I 0.852
HelroG80374 Helobdella robusta HelroG80374 I 0.846
ISCW006352 Ixodes scapularis ISCW006352 I 0.846
Ogr12767 Ophisaurus gracilis Ogr12767 I 0.841
Smp_160670 Schistosoma mansoni Smp_160670 I 0.831
PTRK_0000512100 Parastrongyloides trichosuri PTRK_0000512100 I 0.830
EFV57892 Trichinella spiralis EFV57892 I 0.830
CRE07226 Caenorhabditis remanei CRE07226 I 0.830
CBN04513 Caenorhabditis brenneri CBN04513 I 0.830
T265_09221 Opisthorchis viverrini T265_09221 I 0.830
MESCA003564 Megaselia scalaris MESCA003564 I 0.830
RSKR_0000862000 Rhabditophanes kr3021 RSKR_0000862000 I 0.824
AAEL002321 Aedes aegypti AAEL002321 I 0.824
A_05170 Schistosoma haematobium A_05170 I 0.820
SMTD_0000837201 Schistosoma mattheei SMTD_0000837201 I 0.820
AMIN002127 Anopheles minimus AMIN002127 I 0.819
ASIS012967 Anopheles sinensis ASIS012967 I 0.819
AQUA008308 Anopheles quadriannulatus AQUA008308 I 0.819
ASTEI06200 Anopheles stephensi ASTEI06200 I 0.819
AGAP000063 Anopheles gambiae AGAP000063 I 0.819
AALB006354 Anopheles albimanus AALB006354 I 0.819
ENSTSYG00000011965 Tarsius syrichta ENSTSYG00000011965 I 0.819
AARA001115 Anopheles arabiensis AARA001115 I 0.819
vab-3 Caenorhabditis elegans WBGene00006870 I 0.819
Afo_R014630 Aptenodytes forsteri Afo_R014630 I 0.818
D917_00854 Trichinella nativa D917_00854 I 0.817
PAX6 Pan troglodytes ENSPTRG00000003474 I 0.816
csin101119 Clonorchis sinensis csin101119 I 0.815
SPAL_0001466800 Strongyloides papillosus SPAL_0001466800 I 0.813
SSTP_0001059400 Strongyloides stercoralis SSTP_0001059400 I 0.813
AMEC021831 Anopheles melas AMEC021831 I 0.813
AFUN011575 Anopheles funestus AFUN011575 I 0.813
SVE_0819200 Strongyloides venezuelensis SVE_0819200 I 0.813
HelroG173449 Helobdella robusta HelroG173449 I 0.808
AFAF009619 Anopheles farauti AFAF009619 I 0.807
ADAC003449 Anopheles darlingi ADAC003449 I 0.807
ACHR008920 Anopheles christyi ACHR008920 I 0.806
T265_14971 Opisthorchis viverrini T265_14971 I 0.805
LLOJ005149 Lutzomyia longipalpis LLOJ005149 I 0.802
tetur09g00660 Tetranychus urticae tetur09g00660 I 0.797
Smp_170750 Schistosoma mansoni Smp_170750 I 0.792
MCOS_0000220101 Mesocestoides corti MCOS_0000220101 I 0.791
ACUA021227 Anopheles culicifacies ACUA021227 I 0.786
D915_07175 Fasciola hepatica D915_07175 I 0.786
AEPI005803 Anopheles epiroticus AEPI005803 I 0.780
BXY_1643500 Bursaphelenchus xylophilus BXY_1643500 I 0.780
CpipJ_CPIJ006390 Culex pipiens CpipJ_CPIJ006390 I 0.775
CPIJ006390 Culex quinquefasciatus CPIJ006390 I 0.775
csin110224 Clonorchis sinensis csin110224 I 0.769
ADIR000968 Anopheles dirus ADIR000968 I 0.743
fgenesh2_pg.scaffold_199000043 Branchiostoma floridae fgenesh2_pg.scaffold_199000043 I 0.736
NEMVEDRAFT_v1g239535 Nematostella vectensis NEMVEDRAFT_v1g239535 I 0.736
TsM_000166900 Taenia solium TsM_000166900 I 0.731
HmN_000466300 Hymenolepis microstoma HmN_000466300 I 0.731
fgenesh2_pg.scaffold_23000118 Branchiostoma floridae fgenesh2_pg.scaffold_23000118 I 0.722
TTAC_0000231001 Hydatigera taeniaeformis TTAC_0000231001 I 0.720
ENSMEUG00000015900 Macropus eugenii ENSMEUG00000015900 I 0.719
KGM_00908 Danaus plexippus KGM_00908 I 0.705